Recent state of lindane metabolism. Part III.

Macholz, R.; Kujawa, M.

doi:10.1007/978-1-4612-5104-0_4

Cited by 26 publications

(11 citation statements)

References 97 publications

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“…One of the metabolites could be established as a glucuronide conjugate and another as a sulfate conjugate. In homeothermes, hexachlorocyclohexene, pentachlorocyclohexene, and tetrachlorocyclohexene are described as the key lindane metabolites (of more than 80 metabolites of different chemical structures and relevance) [27].…”

Section: Discussionmentioning

confidence: 99%

Disposition and depuration of lindane (γ‐HCH) and polychlorinated biphenyl‐110 (2,3,3′,4′,6‐pentachlorobiphenyl) in cod (Gadus morhua) and bullrout (Myoxocephalus scorpius) after single oral exposures

Ruus¹,

Skaare²,

Ingebrigtsen³

2001

Enviro Toxic and Chemistry

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The disposition and depuration of lindane (gamma-hexachlorocyclohexane [HCH]) and polychlorinated biphenyl (PCB)-110 (2,3,3',4',6-pentachlorobiphenyl), orally administered to cod (Gadus morhua) and bullrout (Myoxocephalus scorpius), were investigated using whole-body autoradiography, liquid scintillation counting, and gas chromatography with electron-capture detection. Both gamma-HCH and PCB-110 were distributed mainly to lipid-rich organs after absorption from the gastrointestinal tract of cod and bullrout. Compared to bullrout liver, the cod liver contained higher concentrations of both compounds, reflecting the distribution of fat in the two species. In both species, the depuration time for gamma-HCH was shorter than for PCB-110. Both substances were excreted via bile and urine, largely as water-soluble metabolites. The water-soluble bile metabolites, together with PCB-110 metabolites associated to endogenous macromolecules, strongly indicate that this compound is metabolized in both species.

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Section: Discussionmentioning

confidence: 99%

Disposition and depuration of lindane (γ‐HCH) and polychlorinated biphenyl‐110 (2,3,3′,4′,6‐pentachlorobiphenyl) in cod (Gadus morhua) and bullrout (Myoxocephalus scorpius) after single oral exposures

Ruus¹,

Skaare²,

Ingebrigtsen³

2001

Enviro Toxic and Chemistry

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“…Residues of lindane have been detected in drinking water sources and beverages as well as in foods [1]. The large-scale uses of lindane coupled with its extreme persistence and slow degradation have led to a global problem [2]. Chemical analysis of branded packaged drinking water (commonly known as bottled water) conducted by the Center for Science and Environment, New Delhi, India, has revealed that bottled water of all the major brands contain high doses of pesticide residues [3].…”

Section: Introductionmentioning

confidence: 99%

Degradation of lindane from aqueous solutions using iron sulfide nanoparticles stabilized by biopolymers

Paknikar

Nagpal

Pethkar

et al. 2005

Science and Technology of Advanced Materials

136

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Lindane (g-hexachlorocyclohexane) is an organochlorine pesticide and a Persistent Organic Pollutant (POP). Lindane residues have been detected in drinking water sources and development of viable methods for their removal is a global priority. Iron based nanomaterials have been shown to effectively transform chlorinated organic compounds. However, their uses in the treatment of drinking water and beverages have toxicity concerns. In the present study, FeS nanoparticles were synthesized by the wet chemical method and were stabilized using a polymer from the basidiomycetous fungus, Itajahia sp. The stabilized nanoparticles could degrade lindane (5 mg/l) with an efficiency of 94% in 8 h. In a subsequent microbiological treatment, residual lindane, its partially degraded intermediates as well as the stabilizing polymer could be completely degraded in 1 h. The latter process facilitated aggregation of FeS, which could be easily removed by filtration. This novel integrated nano-biotechnological method holds the promise of providing an efficient, safe, and cost-effective solution to the problem of removal of chlorinated pollutants from water sources. q

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“…In Italy, only the yHCH isomer (lindane) is still used for agricultural purposes. Nevertheless, other HCH isomers, attributed either to nonagricultural sources such as tanneries [I J or to lindane isomerization [2], are still found in the environment. Recently, a-and y-HCH have been detected in the wet deposition of northern Italy at levels as high as 63 ng/L and 400 ng/L, respectively [3].…”

Section: Introductionmentioning

confidence: 99%

Factors Affecting the Bioconcentration of Hexachlorocyclohexanes in Early Life Stages of Oncorhynchus Mykiss

Viganò¹,

Galassi²,

Gatto³

1992

Environ Toxicol Chem

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A commercial mixture of α‐, β‐, γ‐, and δ‐hexachlorocyclohexane (‐HCH) isomers has been tested for bioconcentration on early life stages of Oncorhynchus mykiss. Experimental results were elaborated by means of BIOCON, an interactive program for personal computers that provides bioconcentration factors (BCFs) and kinetic uptake and depuration coefficients as well as their standard deviations. The comparisons performed on a statistical basis evidenced few differences among the bioconcentration capability of larval stages, contrary to what was observed in previous studies with other chemicals. In the early juvenile stage, α‐ and δ‐HCH are characterized by higher BCFs than the γ‐isomer. The role of lipids is also investigated. The total lipid content seems to play a major role in influencing bioaccumulation parameters but cannot thoroughly explain BCF variability, which must be ascribed to other factors such as life stage and lipid composition.

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Recent state of lindane metabolism. Part III.

Cited by 26 publications

References 97 publications

Disposition and depuration of lindane (γ‐HCH) and polychlorinated biphenyl‐110 (2,3,3′,4′,6‐pentachlorobiphenyl) in cod (Gadus morhua) and bullrout (Myoxocephalus scorpius) after single oral exposures

Disposition and depuration of lindane (γ‐HCH) and polychlorinated biphenyl‐110 (2,3,3′,4′,6‐pentachlorobiphenyl) in cod (Gadus morhua) and bullrout (Myoxocephalus scorpius) after single oral exposures

Degradation of lindane from aqueous solutions using iron sulfide nanoparticles stabilized by biopolymers

Factors Affecting the Bioconcentration of Hexachlorocyclohexanes in Early Life Stages of Oncorhynchus Mykiss

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