Recent studies on electrospinning preparation of patterned, core–shell, and aligned scaffolds

Abstract

Electrospinning is one of the most important ways to prepare continuous, high porosity, large specific surface area, and uniform diameter micro-and nanoscale fibers. So, it has been widely used in the preparation of micro/nano-sized polymer scaffolds for tissue engineering in recent years. In addition to the versatility in material selection and the processing variables, electrospinning also provides a lot of methods to regulate fiber structure and scaffolds morphology. For example, the near-field electrospinning can provide a method to solve the problem of uncontrollable fiber path; the melt electrospinning eliminates the risk of solvent residue in the construct; the addition of different auxiliary electrodes can make the fiber patterned. This review introduces the underlying principle and characteristics of above electrospinning applied in biomedicine. Herein, we highlight a comprehensive understanding of the technical aspect of this technology for versatile fibers with patterned, core-shell and aligned morphology.

Supercritical carbon dioxide assisted fabrication of biomimetic sodium alginate/silk fibroin nanofibrous scaffolds

“…The size of nanopores between the nanofibers was 200–500 nm (Figure 2b, d, f). According to the previous literatures, the ECM has a pore size of approximately 100–300 nm 37 and the size of the collagen fiber in the natural ECM is 50–500 nm 38 . Therefore, the SA/SF scaffolds fabricated by SC‐CO 2 technology could mimic the structure of nature ECM well.…”

Enhanced properties of poly(ε‐caprolactone)/polyvinylpyrrolidone electrospun scaffolds fabricated using 1,1,1,3,3,3‐hexafluoro‐2‐propanol

“…Due to unique mechanical properties, biocompatibility and biodegradability, poly(ε‐caprolactone) (PCL)‐based materials found numerous biomedical applications serving as delivery systems, coating materials, and matrixes for the tissue regeneration 1,2 . In particular, PCL‐based electrospun scaffolds are intensively used for the delivery of therapeutic agents, protein molecules, and other biologically active substances 3–7 …”

“…Due to unique mechanical properties, biocompatibility and biodegradability, poly(ε-caprolactone) (PCL)-based materials found numerous biomedical applications serving as delivery systems, coating materials, and matrixes for the tissue regeneration. 1,2 In particular, PCL-based electrospun scaffolds are intensively used for the delivery of therapeutic agents, protein molecules, and other biologically active substances. [3][4][5][6][7] The other polymer being widely applied in biomaterial field is polyvinylpyrrolidone (PVP), which is characterized by low toxicity, biocompatibility, and stability as well as solubility in both water and organic solvents.…”

Electrospun Nanofiber Meshes With Endometrial MSCs Modulate Foreign Body Response by Increased Angiogenesis, Matrix Synthesis, and Anti-Inflammatory Gene Expression in Mice: Implication in Pelvic Floor

“…collagens and elastin) that provide a scaffold to hold cells together through numerous chemical and physical stimuli at the molecular level. Nanofabrication of scaffolds recapitulates such biomimetic nanoscale architectural cues (Mukherjee et al, 2013;Liu et al, 2018a). As a result, meshes designed with nanoscale fibers using electrospinning techniques promote cell-cell and cell-biomaterial interactions.…”