Recent trends in drug-delivery systems for the treatment of diabetic retinopathy and associated fibrosis

Silva, Marta; Peng, Tangming; Zhao, Xia; Li, Shuai; Farhan, Mohd; Zheng, Wenhua

doi:10.1016/j.addr.2021.04.007

Cited by 35 publications

(23 citation statements)

References 247 publications

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“…Histological examination of NCQ treated rats showed a normal renal architecture correlated with the less necrotic cells, less leukocytes infiltration, and consequent inflammation besides a normal structural and functional tissue and organelles such as Bowman’s capsules or the urinary chambers. Organ dysfunction is frequently accompanied by fibrotic alterations in both diabetic people and animal models of the disease [ 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. Fibrosis may have a role in the etiology of diabetic retinopathy and neuropathy as well as the pathogenesis of diabetic cardiomyopathy, nephropathy, and liver failure [ 55 , 56 , 57 , 58 , 59 , 60 , 61 ].…”

Section: Discussionmentioning

confidence: 99%

“…Organ dysfunction is frequently accompanied by fibrotic alterations in both diabetic people and animal models of the disease [ 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. Fibrosis may have a role in the etiology of diabetic retinopathy and neuropathy as well as the pathogenesis of diabetic cardiomyopathy, nephropathy, and liver failure [ 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. Long-term diabetic patients frequently have severe fibrotic lesions in their heart, kidney and liver [ 55 , 56 , 57 , 58 , 59 , 60 , 61 ].…”

Section: Discussionmentioning

confidence: 99%

“…Fibrosis may have a role in the etiology of diabetic retinopathy and neuropathy as well as the pathogenesis of diabetic cardiomyopathy, nephropathy, and liver failure [ 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. Long-term diabetic patients frequently have severe fibrotic lesions in their heart, kidney and liver [ 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. The mechanism is unclear; however, these fibrotic alterations are caused by metabolic dysfunction, or reflect atherosclerotic disease-related consequences, or the high prevalence of other pro-fibrotic comorbid conditions, such as hypertension and dyslipidemias.…”

Section: Discussionmentioning

confidence: 99%

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Investigation of the Renal Protective Effect of Combined Dietary Polyphenols in Streptozotocin-Induced Diabetic Aged Rats

et al. 2022

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Natural polyphenols are widely reported to have a large range of pharmacological properties, especially antioxidant activities and free radical scavenging capacities. In this study, we investigate the effects of naringin, chlorogenic acid, and quercetin mixtures (NCQ) on renal fibrosis in streptozotocin (STZ)-induced diabetic aged rats and its underlying mechanisms for ten consecutive weeks. The oxidative defense system in the kidneys of treated rats was found to be improved. Several biomarkers were investigated including the blood urea nitrogen, creatinine, and uric acid. Moreover, antioxidant parameters were evaluated and we found that superoxide dismutase, catalase, glutathione peroxidase, Na+-K+-ATPase activities, the nitric oxide production, the protein carbonyl, the advanced oxidation protein products, lipid peroxidation, and reduced glutathione levels were all significantly balanced and close to control values. In addition, NCQ restored renal injuries and fibrosis as assessed by histological method and molecular biology investigation of the matrix metalloproteinase, the transforming growth factor-beta TGF-β, the tumor necrosis factor TNFα, and p53 expression. Our study proposes the NCQ combination as potential plant-derived bioactive compounds to prevent diabetic nephropathy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Investigation of the Renal Protective Effect of Combined Dietary Polyphenols in Streptozotocin-Induced Diabetic Aged Rats

et al. 2022

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“…A novel intraocular drug delivery system can potentially avoid the side effect of repeated intravitreal injection. Therefore, materials such as polymeric molecules, nanoparticles, microparticles and intraocular devices such as ocular-implanted injection and sustained release drug delivery devices have been invented and clinically testified to optimize existing interventions [111,112]. Epigenetic modifications including DNA methylation, histone modification, non-coding RNA, and chromatin remodeling are also found involved in DR development, which offer novel biomarkers and treatment targets for researchers [113].…”

Section: Other Promising Strategies For Drmentioning

confidence: 99%

Experiment-Based Interventions to Diabetic Retinopathy: Present and Advances

Liu

2022

IJMS

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Diabetic retinopathy is the major blinding disease among working-age populations, which is becoming more significant due to the growth of diabetes. The metabolic-induced oxidative and inflammatory stress leads to the insult of neovascular unit, resulting in the core pathophysiology of diabetic retinopathy. Existing therapies focus on the inflammation, oxidation, and angiogenesis phenomena of diabetic retinopathy, without effect to radically cure the disease. This review also summarizes novel therapeutic attempts for diabetic retinopathy along with their advantages and disadvantages, mainly focusing on those using cellular and genetic techniques to achieve remission on a fundamental level of disease.

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“…The corticosteroid drugs can be administered through topical route generally employed in the form of eye drops, systemic delivery via oral or intravenous routes, periocular delivery or transscleral delivery includes subconjunctival, subtenon, retrobulbar, peribulbar and posterior juxtascleral injections, which are less invasive than intraocular routes and intraocular delivery includes the intravitreal and suprachoroidal routes. [ 73 ]…”

Section: S Ystemic F Actor C ...mentioning

confidence: 99%

Diabetic Retinopathy

Mounirou¹,

Adam²,

Yakoura³

et al. 2022

Indian Journal of Endocrinology and Metabolism

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Diabetic retinopathy (DR), substantially impacts the quality of life of diabetic patients, it remains, in developed countries, the leading cause of vision loss in working-age adults (20–65 years). Currently, about 90 million diabetics suffer from DR. DR is a silent complication that in its early stages is asymptomatic. However, over time, chronic hyperglycemia can lead to sensitive retinal damage, leading to fluid accumulation and retinal haemorrhage (HM), resulting in cloudy or blurred vision. It can, therefore, lead to severe visual impairment or even blindness if left untreated. It can be classified into nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR). NPDR is featured with intraretinal microvasculature changes and can be further divided into mild, moderate, and severe stages that may associate with diabetic macular oedema (DME). PDR involves the formation and growth of new blood vessels (retinal neovascularisation) under low oxygen conditions. Early identification and treatment are key priorities for reducing the morbidity of diabetic eye disease. In the early stages of DR, a tight control of glycemia, blood pressure, plasma lipids, and regular monitoring can help prevent its progression to more advanced stages. In advanced stages, the main treatments of DR include intraocular injections of anti-vascular endothelial growth factor (VEGF) antibodies, laser treatments, and vitrectomy. The aim of this review is to provide a comprehensive overview of the published literature pertaining to the latest progress in the treatment of DR.

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Recent trends in drug-delivery systems for the treatment of diabetic retinopathy and associated fibrosis

Cited by 35 publications

References 247 publications

Investigation of the Renal Protective Effect of Combined Dietary Polyphenols in Streptozotocin-Induced Diabetic Aged Rats

Investigation of the Renal Protective Effect of Combined Dietary Polyphenols in Streptozotocin-Induced Diabetic Aged Rats

Experiment-Based Interventions to Diabetic Retinopathy: Present and Advances

Diabetic Retinopathy

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