Recent trends in macromolecule-conjugated hybrid quantum dots for cancer theranostic applications

Boopathy, Lokesh Kumar; Gopal, Thiyagarajan; Anitha, R.; Kandy, Rakhee Rathnam Kalari; Arumugam, Madan Kumar

doi:10.1039/d3ra02673f

Cited by 3 publications

(1 citation statement)

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“…However, there have been significant improvements in treatment options and survivability due to research and trials. There are different therapeutic approaches for cancer diagnosis and treatment [7][8][9]. The common approaches include chemotherapy, radiotherapy, immunotherapy, enzyme therapy, antibiotics, and surgery [2].…”

Section: Introductionmentioning

confidence: 99%

Anticancer Property of Digera muricata Leaf Extract: An In Vitro Study

Varadarajan,

Roy,

Jagadeswaran

2023

Cureus

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The aim was to evaluate the anticancer potential of Digera muricata ethanolic leaf extract on MG-63 osteosarcoma cell lines. Materials and methodsThe anti-cancer properties of Digera muricata ethanolic leaf extract were evaluated on osteosarcoma cell lines using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and the morphological changes in MG-63 cells were assessed after 24 hours using microscopic observation. Additionally, fluorescence microscopy was employed to evaluate the apoptotic changes after acridine orange/ethidium bromide (AO/EtBr) dual staining. ResultsThe MTT assay revealed a dose-dependent cell death. The cell viability decreased with increase in concentrations of the extract, The cell viability was 89.98 ± 4.89 percentage at 25 μg/ml and 15.64 ± 3.64 percentage at 200 μg/ml concentrations. A concentartion of 116.95 μg/ml showed 50% inhibition (IC 50 ). The morphological and dual staining studies also showed the extract's effectiveness in inducing apoptosis. ConclusionThe ethanolic leaf extract of D. muricata could impart good antiproliferative activity in MG-63 cell lines. The extract could also induce apoptosis and hence, it may be considered as a potential anticancer agent for the development of drug formulation for the treatment of osteosarcoma.

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