Recent Trends in Ophthalmic Drug Delivery

Abstract

The major challenge faced by today’s pharmacologist and formulation scientist is ocular drug delivery. Delivery of drugs to the targeted ocular tissues is restricted by various precorneal, dynamic and static ocular barriers. Also, therapeutic drug levels are not maintained for longer duration in target tissues. To overcome the ocular drug delivery barriers and improve ocular bioavailability, various conventional and novel drug delivery systems have been developed such as emulsion, ointments, suspensions, aqueous gels, nanomicelles, nanoparticles, liposomes, dendrimers, implants, contact lenses, nanosuspensions, microneedles and in situ thermosensitive gels for the earlier mention ocular diseases

Comparative Analysis of Sunscreen Nanoencapsulation Processes

“…Particularly, nanotechnology techniques constitute promising tools in the field of cosmetic dermatology, as nanoencapsulation allows for increased stability of active compounds (including photoprotective substances); protects active compounds from physical, chemical and biological degradation; can allow for the controlled release of active species; and can avoid undesired absorption of active compounds by living tissues. [2][3][4] Regarding sunscreens, nanoencapsulation can be performed to retain active compounds in the outer layers of the skin, the preferred site of action. [5] Besides, nanoparticles can also promote additional blocking against ultraviolet radiation, acting as physical sunscreens.…”

Development and Investigation of Timolol Maleate and Latanoprost Combination Liposomes for the Treatment of Glaucoma

“…Similarly, frequent instillation of concentrated medication is required at the site of action which is patient incompliance. 1 Glaucoma is an eye disease in which the optic nerve is damaged in a characteristic pattern. This can permanently damage vision in the affected eyes and lead to blindness if left untreated.…”