Recent trends of contrast agents in ultrasound imaging: a review of the classifications and applications

Tarighatnia, Ali; Fouladi, Mohammad Reza; Nader, Nader D.; Aghanejad, Ayuob; Ghadiri, Hossein

doi:10.1039/d1ma00969a

Cited by 29 publications

(10 citation statements)

References 136 publications

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“…Sound waves on the other hand due to their longer wavelength, can penetrate deep tissues easily without any significant optical obstruction due to skin or microscopic cellular environment 34 . Supplemented with appropriate contrast agents, ultrasound imaging generates high-contrast images comparable to other imaging tools 35 . Owing to its interaction and absorption by the biological tissues, ultrasound can also cause temperature rise, resulting in activation of the immune response or cellular death due to ablation 36 , 37 .…”

Section: Bioimagingmentioning

confidence: 99%

Current Trends in Nanotheranostics: A Concise Review on Bioimaging and Smart Wearable Technology

Sharma¹

2023

Nanotheranostics

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The area of interventional nanotheranostics combines the use of interventional procedures with nanotechnology for the detection and treatment of physiological disorders. Using catheters or endoscopes, for example, interventional techniques make use of minimally invasive approaches to diagnose and treat medical disorders. It is feasible to increase the precision of these approaches and potency by integrating nanotechnology. To visualize and target various parts of the body, such as tumors or obstructed blood veins, one can utilize nanoscale probes or therapeutic delivery systems. Interventional nanotheranostics offers targeted, minimally invasive therapies that can reduce side effects and enhance patient outcomes, and it has the potential to alter the way that many medical illnesses are handled. Clinical enrollment and implementation of such laboratory scale theranostics approach in medical practice is promising for the patients where the user can benefit by tracking its physiological state. This review aims to introduce the most recent advancements in the field of clinical imaging and diagnostic techniques as well as newly developed on-body wearable devices to deliver therapeutics and monitor its due alleviation in the biological milieu.

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Section: Bioimagingmentioning

confidence: 99%

Current Trends in Nanotheranostics: A Concise Review on Bioimaging and Smart Wearable Technology

Sharma¹

2023

Nanotheranostics

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“…Moreover, some ovarian cancer patients whose cancer is recurrent or resistant to standard regimens are mostly incurable. Hence, the advent of early diagnostic tools and effective targeted therapy could be a promising approach to combat ovarian cancer [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Targeted Delivery of Sunitinib by MUC-1 Aptamer-Capped Magnetic Mesoporous Silica Nanoparticles

et al. 2023

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Magnetic mesoporous silica nanoparticles (MMSNPs) are being widely investigated as multifunctional novel drug delivery systems (DDSs) and play an important role in targeted therapy. Here, magnetic cores were synthesized using the thermal decomposition method. Further, to improve the biocompatibility and pharmacokinetic behavior, mesoporous silica was synthesized using the sol-gel process to coat the magnetic cores. Subsequently, sunitinib (SUN) was loaded into the MMSNPs, and the particles were armed with amine-modified mucin 1 (MUC-1) aptamers. The MMSNPs were characterized using FT-IR, TEM, SEM, electrophoresis gel, DLS, and EDX. MTT assay, flow cytometry analysis, ROS assessment, and mitochondrial membrane potential analysis evaluated the nanoparticles’ biological impacts. The physicochemical analysis revealed that the engineered MMSNPs have a smooth surface and spherical shape with an average size of 97.6 nm. The biological in vitro analysis confirmed the highest impacts of the targeted MMSNPs in MUC-1 overexpressing cells (OVCAR-3) compared to the MUC-1 negative MDA-MB-231 cells. In conclusion, the synthesized MMSNP-SUN-MUC-1 nanosystem serves as a unique multifunctional targeted delivery system to combat the MUC-1 overexpressing ovarian cancer cells.

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“…[12][13][14] However, the stability of phasechange contrast agents may be further improved to match the stability of solid core contrast agents. 15 Paclitaxel is a hydrophobic molecule derived from Pacific yew Taxus brevifolia that was first approved by the US Food and Drug Administration for treatment of ovarian and breast cancer in 1992. [16][17][18][19] However, the drug's hydrophobicity makes efficient drug delivery of paclitaxel challenging.…”

Section: Introductionmentioning

confidence: 99%

“… 12–14 However, the stability of phase-change contrast agents may be further improved to match the stability of solid core contrast agents. 15 …”

Section: Introductionmentioning

confidence: 99%

Cellulose Nanofiber-Coated Perfluoropentane Droplets: Fabrication and Biocompatibility Study

Loskutova¹,

Torras²,

Ying³

et al. 2023

IJN

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To study the effect of cellulose nanofiber (CNF)-shelled perfluoropentane (PFP) droplets on the cell viability of 4T1 breast cancer cells with or without the addition of non-encapsulated paclitaxel. Methods: The CNF-shelled PFP droplets were produced by mixing a CNF suspension and PFP using a homogenizer. The volume size distribution and concentration of CNF-shelled PFP droplets were estimated from images taken with an optical microscope and analyzed using Fiji software and an in-house Matlab script. The thermal stability was qualitatively assessed by comparing the size distribution and concentration of CNF-shelled PFP droplets at room temperature (~22°) and 37°C. The cell viability of 4T1 cells was measured using a 3-[4,5-dimethylthiazol-2yl]-2,5-diphenyltetrazolium bromide (MTT) assay. Additionally, a hemolysis assay was performed to assess blood compatibility of CNF-shelled PFP droplets. Results: The droplet diameter and concentration of CNF-shelled PFP droplets decreased after 48 hours at both room temperature and 37°C. In addition, the decrease in concentration was more significant at 37°C, from 3.50 ± 0.64×10 6 droplets/mL to 1.94 ± 0.10×10 6 droplets/mL, than at room temperature, from 3.65 ± 0.29×10 6 droplets/mL to 2.56 ± 0.22×10 6 droplets/mL. The 4T1 cell viability decreased with increased exposure time and concentration of paclitaxel, but it was not affected by the presence of CNF-shelled PFP droplets. No hemolysis was observed at any concentration of CNF-shelled PFP droplets. Conclusion: CNF-shelled PFP droplets have the potential to be applied as drug carriers in ultrasound-mediated therapy.

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Recent trends of contrast agents in ultrasound imaging: a review of the classifications and applications

Abstract: Ultrasound (US) imaging, due to its capabilities in real-time imaging, portability, low-cost, and favorite safety, is frequently used as a diagnostic modality for visualization of different diseases. US imaging is...

Cited by 29 publications

References 136 publications

Current Trends in Nanotheranostics: A Concise Review on Bioimaging and Smart Wearable Technology

Current Trends in Nanotheranostics: A Concise Review on Bioimaging and Smart Wearable Technology

Targeted Delivery of Sunitinib by MUC-1 Aptamer-Capped Magnetic Mesoporous Silica Nanoparticles

Cellulose Nanofiber-Coated Perfluoropentane Droplets: Fabrication and Biocompatibility Study

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