Recent trends of micro and nanostructured conducting polymers in health and environmental applications

Alvarenga, Gabriela de; Hryniewicz, Bruna M.; Jasper, Isabela; Silva, Rafael J.; Klobukoski, Vanessa; Costa, Floriatan Santos; Cervantes, Thiago Nogueira Marques; Amaral, Clarice D.B.; Schneider, Jéssica Tamara; Bach-Toledo, Larissa; Peralta‐Zamora, Patricio; Valerio, Tatiana Lima; Soares, Frederico Luis Felipe; Silva, Bruno J.G.; Vidotti, Marcio

doi:10.1016/j.jelechem.2020.114754

Cited by 24 publications

(8 citation statements)

References 221 publications

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“…There are two types of scaffolds capable of promoting bioactivity in the implantation areas: microfilamentous and microporous scaffolds [ 84 ], with three composition types: natural, synthetic and hybrid [ 89 ], and two forms of application: patches and injections [ 103 ]. Ideally, each must be able to conduct electricity, allow for the differentiation of the stem cells into the cardiomyocytes and have Young’s modulus similar to the native myocardial tissue [ 104 , 105 ]. If a scaffold meets these requirements, it can improve the cell proliferation and differentiation processes and stimulate the production of biomolecules [ 106 ].…”

Section: Scaffolds For Cardiac Tissue Regenerationmentioning

confidence: 99%

Chitosan-Based Scaffolds for the Treatment of Myocardial Infarction: A Systematic Review

2023

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Cardiovascular diseases (CVD), such as myocardial infarction (MI), constitute one of the world’s leading causes of annual deaths. This cardiomyopathy generates a tissue scar with poor anatomical properties and cell necrosis that can lead to heart failure. Necrotic tissue repair is required through pharmaceutical or surgical treatments to avoid such loss, which has associated adverse collateral effects. However, to recover the infarcted myocardial tissue, biopolymer-based scaffolds are used as safer alternative treatments with fewer side effects due to their biocompatibility, chemical adaptability and biodegradability. For this reason, a systematic review of the literature from the last five years on the production and application of chitosan scaffolds for the reconstructive engineering of myocardial tissue was carried out. Seventy-five records were included for review using the “preferred reporting items for systematic reviews and meta-analyses” data collection strategy. It was observed that the chitosan scaffolds have a remarkable capacity for restoring the essential functions of the heart through the mimicry of its physiological environment and with a controlled porosity that allows for the exchange of nutrients, the improvement of the electrical conductivity and the stimulation of cell differentiation of the stem cells. In addition, the chitosan scaffolds can significantly improve angiogenesis in the infarcted tissue by stimulating the production of the glycoprotein receptors of the vascular endothelial growth factor (VEGF) family. Therefore, the possible mechanisms of action of the chitosan scaffolds on cardiomyocytes and stem cells were analyzed. For all the advantages observed, it is considered that the treatment of MI with the chitosan scaffolds is promising, showing multiple advantages within the regenerative therapies of CVD.

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Section: Scaffolds For Cardiac Tissue Regenerationmentioning

confidence: 99%

Chitosan-Based Scaffolds for the Treatment of Myocardial Infarction: A Systematic Review

2023

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“…Conductive polymers (CP), such as polypyrrole, polyaniline, or polythiophene, represent ideal candidates for further electrode modification due to their electroactivity [26,27]. CPs are currently used in various applications including health care or energy storage [28] [29]. Furthermore, nanoparticles are capable of improving the properties of conducting polymers, owing to their nanostructures with the expanded active surface area, which results in increased conductivity, electrochemical activity, and higher electron transporter portability [28].…”

Section: Introductionmentioning

confidence: 99%

Polymer-based Electrochemical Sensor: Fast, Accurate, and Simple Insulin Diagnostics Tool

et al. 2023

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Study of the use of polymers with higher conductivity like polypyrrole, and polyaniline in the electrochemical insulin sensors can overcome the drawbacks arising from the ongoing use of non-conductive polymer membrane. Conductive polymer membranes maintain the positive properties of polymers, like improved stability, reproducibility, and even increase the current response of the prepared sensor toward insulin oxidation. Three different screen-printed electrodes modified with polyaniline, polypyrrole, or chitosan with electrochemically deposited nickel nanoparticles ensuring insulin oxidation were prepared. The electrode morphology was examined via SEM with EDX analysis. Also, the electroactive surface area and stability were determined by voltammetric methods. Based on the results, the SPCEs modified by polypyrrole and nickel nanoparticles were determined as the most appropriate for the insulin determination. The NiNPs-PPy-SPCE exhibited a linear range (500 nM–5 µM), a low-down limit of detection (38 nM), high sensitivity (3.98 µA/µM), and excellent result from insulin determination in real samples (human blood serum). The results confirmed the high potential of developed sensor for future research focused on detection of insulin via electrochemistry methods in clinical samples. Graphical Abstract

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“…For example, polymeric materials with a high molecular weight as well as with a high degree of cross-linking tend to remain in a solid state, leading to difficult disintegration and dispersion in liquid media [ 21 ]. Likewise, polymeric materials with ease of compaction, high porosity, and various functional groups can act with adsorption, extraction, and preconcentration systems [ 22 ]. In contrast, polymeric materials consisting of individual chains with medium and low molecular weights, as well as with polar functional groups (OH, COOH, NH2, i.a.…”

Section: Introductionmentioning

confidence: 99%

Biopolymers as a Potential Alternative for the Retention of Pollutants from Vinasse: An In Silico Approach

Aristizabal,

Ciro,

Liscano

et al. 2023

Polymers

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Vinasse, a waste from the bioethanol industry, presents a crucial environmental challenge due to its high organic matter content, which is difficult to biodegrade. Currently, no sustainable alternatives are available for treating the amount of vinasse generated. Conversely, biopolymers such as cellulose, carboxymethylcellulose, and chitosan are emerging as an interesting alternative for vinasse control due to their flocculating capacity against several organic compounds. This study seeks to determine the thermodynamic behavior of in silico interactions among three biopolymers (cellulose, carboxymethylcellulose, and chitosan) regarding 15 organic compounds found in vinasse. For this, the Particle Mesh Ewald (PME) method was used in association with the Verlet cutoff scheme, wherein the Gibbs free energy (ΔG) was calculated over a 50 ns simulation period. The findings revealed that cellulose showed a strong affinity for flavonoids like cyanidin, with a maximum free energy of −84 kJ/mol and a minimum of −55 kJ/mol observed with phenolic acids and other flavonoids. In contrast, chitosan displayed the highest interactions with phenolic acids, such as gallic acid, reaching −590 kJ/mol. However, with 3-methoxy-4-hydroxyphenyl glycol (MHPG), it reached an energy of −70 kJ/mol. The interaction energy for flavonoid ranged from −105 to −96 kJ/mol. Finally, carboxymethylcellulose (CMC) demonstrated an interaction energy with isoquercetin of −238 kJ/mol, while interactions with other flavonoids were almost negligible. Alternatively, CMC exhibited an interaction energy of −124 kJ/mol with MHPG, while it was less favorable with other phenolic acids with minimal interactions. These results suggest that there are favorable interactions for the interfacial sorption of vinasse contaminants onto biopolymers, indicating their potential for use in the removal of contaminants from the effluents of the bioethanol industry.

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Recent trends of micro and nanostructured conducting polymers in health and environmental applications

Cited by 24 publications

References 221 publications

Chitosan-Based Scaffolds for the Treatment of Myocardial Infarction: A Systematic Review

Chitosan-Based Scaffolds for the Treatment of Myocardial Infarction: A Systematic Review

Polymer-based Electrochemical Sensor: Fast, Accurate, and Simple Insulin Diagnostics Tool

Biopolymers as a Potential Alternative for the Retention of Pollutants from Vinasse: An In Silico Approach

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