Recent updates in curcumin delivery

Next-Generation Hydrogels as Biomaterials for Biomedical Applications: Exploring the Role of Curcumin

“…There are several approaches to improve the solubility and stability of curcumin, including encapsulating curcumin in lipid carriers and binding to nanoparticles (NPs). , As of late, a complex series of nanotechnology and polymer biomaterials have spoken to the development of more common golden methods . Nanoformulations are used as curcumin delivery systems including polymeric NPs, liposomes, hydrogels, nanoemulsions, nanofibers, lipid transferors, and membranes of polymer mixtures. ,, The advanced curcumin delivery system can increase efficiency, solubility, and bioavailability as well as raising blood half-life, and reduce deterioration rate . Currently, a mixed synthetic and natural polymer hybrid nanocomposite hydrogel film is introduced as a new drug delivery method for biomedical applications This system is mainly used for cancer diagnosis and treatment due to its satisfactory spontaneous properties and biological compatibility, low cost, and the sustained release of the biological materials (Table ).…”

A New Productive Approach and Formulative Optimization for Curcumin Nanoliposomal Delivery Systems

“…In the latest scientific literature, more than three thousand papers (source: WOS core collection, curcumin as keyword, years 2022–2023) testify the great interest in this natural compound. The reasons for this considerable attention are the ascertained therapeutic efficacy in arthritis, liver, and neurodegenerative diseases; in several types of cancers, obesity, wound-healing, anti-inflammatory treatments; and as an antibacterial, antioxidant, antispasmodic, and anticoagulant agent [ 8 , 9 , 10 ]. In addition, recently, studies on CUR’s preventive effects on extensive immunosuppression are ongoing to investigate therapeutic potential against SARS-CoV-2 (COVID-19) [ 6 ].…”

“…Moreover, as for most the antioxidant agents, curcumin is unstable and quickly degraded through oxidative processes [ 7 ] during manufacturing and storage [ 9 ]. In this regard, to overcome curcumin dosage limitations, evolutions of nanotechnologies and of their outputs, i.e., nanoparticles (NPs), are extensively discussed in the literature in terms of possible benefits and disadvantages [ 10 , 11 ]. Nanoparticles offer considerable advantages over conventional drug-delivery systems due to their small size and consequently large surface area.…”

“…They can allow transportation and release of drugs with tailorable release kinetics of active ingredients to target side as well as enhanced solubility and stability of most drugs, resulting in improved pharmacokinetic profiles [ 12 , 13 ]. In particular, dedicated investigations for curcumin delivery have emphasized that nanoliposomes are the better administration platforms, even if their use can also manifest adverse effects [ 9 , 10 , 11 , 14 ]. Liposomes are artificial self-assembled colloidal particles consisting of one or more lipid bilayers surrounding an aqueous core.…”

“…It is noteworthy to mention that nanoliposomal formulations have successfully been used in clinical applications as an FDA-approved nanocarrier for a variety of drugs [ 13 ]. Lipocurc TM is the most known curcumin liposomal product that has undergone clinical trials [ 10 , 14 ]. To cite several outcomes, nanoliposome-based delivery systems for CUR have revealed: enhanced bioavailability, better anticancer effects [ 9 , 11 ]; lower adverse effects but also higher cytotoxicity (trials on cell lines for several cancer type) [ 9 ]; enhanced anti-inflammatory proprieties (test in vivo) [ 21 ]; better internalization by cells into cytoplasm, and attenuation of neuroinflammatory reactions (in cell lines/in murine brain tissue) [ 13 ].…”