Receptive status of the endometrium in patients with benign ovarian tumors before and after organ-preserving operations

Tumasyan, E.A.; Biryukov, A.E.; Gracheva, N.A.; Gashimova, A.I.; Ismaiilova, P. D.; Solomatina, A.A.; Mikhaleva, L.M.

doi:10.17116/patol20228404129

Cited by 3 publications

(1 citation statement)

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“…Рецептивность эндометрия у пациенток репродуктивного возраста до и после односторонней аднексэктомии по поводу серозной и муцинозной цистаденом яичников // Морфология. 2022…”

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Receptive status of the endometrium in patients of reproductive age with serous and mucinous ovarian cystadenoma before and after unilateral adnexectomy

Mikhaleva,

Solomatina,

Gashimova

et al. 2023

Morphology

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Background. Currently, there is an increase in benign ovarian tumors, which, according to the results of numerous studies, negatively affect the reproductive health of women. Patients seeking to preserve their reproductive function prefer organ-preserving surgical interventions, however, in clinical practice, adnexectomy is often necessary due to the absence of intact ovarian tissue. Aim. Analysis of the morphofunctional state of the endometrium and its receptivity in patients with serous and mucinous ovarian cystadenomas before and after surgical treatment. Methods. The prospective study included patients of reproductive age with benign epithelial tumors: serous/mucinous cystadenomas who had not received hormonal drugs for six months prior to surgical treatment. 32 patients with serous cystadenoma were included in group I, 30 patients with mucinous cystadenoma in group II. Before and 6-12 months after unilateral salpingo-oophorectomy, a pipel biopsy of the endometrium was performed during the "implantation window". The qualitative and quantitative parameters of pinopodia were studied, the expression of estrogen (ER) and progesterone (PR) receptors in the glands and stroma of the endometrium were studied. Results. In the postoperative period, an increase in the number of mature pinopodia, a growing in the expression of ER in the stroma and PR in the stroma and glands was revealed. When analyzing the data in patients with mucinous cystadenoma After surgical treatment, in patients with mucinous cystadenoma, in comparison with the data of the serous patients in the glandular component of the endometrium, the expression of both ER and PR was lower, and the expression of PR in the stromal component was also lower, a growing in the number of developing pinopodia was recorded. Conclusion. The results of our study showed that benign ovarian tumors is accompanied by disorders of the morphofunctional state and receptivity of the endometrium.

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Receptive status of the endometrium in patients of reproductive age with serous and mucinous ovarian cystadenoma before and after unilateral adnexectomy

Mikhaleva,

Solomatina,

Gashimova

et al. 2023

Morphology

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Morphofunctional characteristics of the endometrium in patients of reproductive age with chronic salpingo-oophoritis

Khalifaeva,

Biryukov,

Gracheva

et al. 2024

Rus. J. Arch. Pathol.

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Endometrial receptive status in patients of reproductive age with diffuse and focal adenomyosis

Mikhaleva

Solomatina

Ismaiilova

et al. 2023

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Introduction Endometriosis ranks second place in the structure of infertility. The development of endometrial dysfunction is one of the infertility factors, which affects the degree of decrease in the receptive abilities of endometrium and subsequent implantation.Purpose of the study was to reveal morpho-functional state of receptivity and nidation ability of endometrium in patients of reproductive age with diffuse and nodal forms of adenomyosis.Materials and methods The study included 104 patients, which were divided into 2 groups. The first group consisted of 30 patients with a diffuse form of adenomyosis, second group included 30 patients with a nodal form. The patients underwent aspiration biopsy of endometrium in the middle secretory phase. The level of ER and PR expression in the glandular and stromal compartments of endometrium was assessed, the percentage and degree of maturity of pinopodes were determined.Results The analysis of ER and PR number in the stromal and glandular components of endometrium in patients with diffuse adenomyosis revealed an increase in the secretion of ER in the glandular cells in contrast to patients of the comparison group. Significant differences in the expression of ER and PR in glandular cells were verified among observed with the nodal form of adenomyosis. The immunohistochemical reaction with antibodies to ER and PR in the nodal form of adenomyosis was significantly higher than in diffuse form. Both in the first and second groups, a decrease in the formation ability of pinopodes on the superficial epithelium was noted.Discussion Adenomyosis leads to damage of the morpho-functional state and receptive abilities of the endometrium. In the nodal form the degree of detected disorders was significantly higher.Conclusion The nodal form of adenomyosis is more common in patients of younger reproductive age and is associated with a higher prevalence of endometrial dysfunction. This is especially important for the selection of adequate modern therapy in order to maintain and improve reproductive function.

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Receptive status of the endometrium in patients with benign ovarian tumors before and after organ-preserving operations

Cited by 3 publications

References 26 publications

Receptive status of the endometrium in patients of reproductive age with serous and mucinous ovarian cystadenoma before and after unilateral adnexectomy

Receptive status of the endometrium in patients of reproductive age with serous and mucinous ovarian cystadenoma before and after unilateral adnexectomy

Morphofunctional characteristics of the endometrium in patients of reproductive age with chronic salpingo-oophoritis

Endometrial receptive status in patients of reproductive age with diffuse and focal adenomyosis

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