Receptor-mediated mitophagy: An emerging therapeutic target in acute kidney injury

Dagar, Neha; Kale, Ajinath; Steiger, Stefanie; Anders, Hans‐Joachim; Malek, Vajir

doi:10.1016/j.mito.2022.08.004

Cited by 20 publications

(8 citation statements)

References 78 publications

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“…What's more, besides Parkin, there are also other E3 ubiquitin ligases that can take part in the ubiquitination of mitochondrial proteins and the induction of mitophagy, such as smad ubiquitination regulatory factor-1 (SMURF1) 31 , mitochondrial E3 ubiquitin protein ligase 1 (MUL1), Gp78 32 and so on. It has been reported that SMURF1 promotes mitophagy by recruiting defective mitochondria rather than relying on p62 33 . In addition, Orvedahl et al found that SMURF1 controls mitophagy by promoting the transfer of autophagic molecules to the generated autophagosome 31 .…”

Section: Mechanisms Of Mitophagymentioning

confidence: 99%

Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation

Lǚ¹,

Li²,

Zhang³

et al. 2023

Theranostics

173

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Cellular mitophagy means that cells selectively wrap and degrade damaged mitochondria through an autophagy mechanism, thus maintaining mitochondria and intracellular homeostasis. In recent years, mitophagy has received increasing attention as a research hotspot related to the pathogenesis of clinical diseases, such as neurodegenerative diseases, cardiovascular diseases, cancer, metabolic diseases, and so on. It has been found that the regulation of mitophagy may become a new direction for the treatment of some diseases. In addition, numerous small molecule modulators of mitophagy have also been reported, which provides new opportunities to comprehend the procedure and potential of therapeutic development. Taken together, in this review, we summarize current understanding of the mechanism of mitophagy, discuss the roles of mitophagy and its relationship with diseases, introduce the existing small-molecule pharmacological modulators of mitophagy and further highlight the significance of their development.

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Section: Mechanisms Of Mitophagymentioning

confidence: 99%

Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation

Lǚ¹,

Li²,

Zhang³

et al. 2023

Theranostics

173

View full text Add to dashboard Cite

show abstract

“…Mitophagy mainly consists of PTEN-induced kinase 1 (PINK1)/parkin RBR E3 ubiquitin-protein ligase (Parkin)-mediated and receptor-mediated mitophagy ( Dagar et al, 2022 ). PINK1 and Parkin play important roles in the formation of autophagosome ( Forbes and Thorburn, 2018 ).…”

Section: Natural Products For Regulating Mitochondrial Functionmentioning

confidence: 99%

“…Then Ubs on OMM recruits ubiquitin-bond autophagy receptors like p62, which interacts with LC3 to form autophagosome ( Kerr et al, 2017 ; Sun et al, 2021 ). These receptors, including B-cell lymphoma 2/adenovirus E1B 19-kDa-interacting protein 3 (BNIP3), BNIP3-like (BNIP3L), FUN14 domain-containing protein 1 (FUNDC1) and the activating molecule in BECN1-regulated autophagy protein 1 (AMBRA1), would bind with LC3 to form autophagosome ( Dagar et al, 2022 ). Then the autophagosome containing injured mitochondria is transported to lysosome for degradation ( Jin et al, 2021 ).…”

Section: Natural Products For Regulating Mitochondrial Functionmentioning

confidence: 99%

Natural products for kidney disease treatment: Focus on targeting mitochondrial dysfunction

2023

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The patients with kidney diseases are increasing rapidly all over the world. With the rich abundance of mitochondria, kidney is an organ with a high consumption of energy. Hence, renal failure is highly correlated with the breakup of mitochondrial homeostasis. However, the potential drugs targeting mitochondrial dysfunction are still in mystery. The natural products have the superiorities to explore the potential drugs regulating energy metabolism. However, their roles in targeting mitochondrial dysfunction in kidney diseases have not been extensively reviewed. Herein, we reviewed a series of natural products targeting mitochondrial oxidative stress, mitochondrial biogenesis, mitophagy, and mitochondrial dynamics. We found lots of them with great medicinal values in kidney disease. Our review provides a wide prospect for seeking the effective drugs targeting kidney diseases.

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“…The term mitophagy first appeared in 2005; since then, the popularity of this topic has grown exponentially [ 5 , 6 ]. Due to the role played by mitochondria in the cell, the topic of mitophagy has attracted researchers in anti-aging medicine [ 7 , 8 ], cardiology [ 9 , 10 ], endocrinology [ 11 , 12 , 13 ], nephrology [ 14 , 15 ], and neuroscience [ 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Differential Role of Active Compounds in Mitophagy and Related Neurodegenerative Diseases

Makarov

Korkotian

2023

Toxins

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Neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s disease, significantly reduce the quality of life of patients and eventually result in complete maladjustment. Disruption of the synapses leads to a deterioration in the communication of nerve cells and decreased plasticity, which is associated with a loss of cognitive functions and neurodegeneration. Maintaining proper synaptic activity depends on the qualitative composition of mitochondria, because synaptic processes require sufficient energy supply and fine calcium regulation. The maintenance of the qualitative composition of mitochondria occurs due to mitophagy. The regulation of mitophagy is usually based on several internal mechanisms, as well as on signals and substances coming from outside the cell. These substances may directly or indirectly enhance or weaken mitophagy. In this review, we have considered the role of some compounds in process of mitophagy and neurodegeneration. Some of them have a beneficial effect on the functions of mitochondria and enhance mitophagy, showing promise as novel drugs for the treatment of neurodegenerative pathologies, while others contribute to a decrease in mitophagy.

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Receptor-mediated mitophagy: An emerging therapeutic target in acute kidney injury

Cited by 20 publications

References 78 publications

Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation

Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation

Natural products for kidney disease treatment: Focus on targeting mitochondrial dysfunction

Differential Role of Active Compounds in Mitophagy and Related Neurodegenerative Diseases

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