Receptors for IgG Fc and Complement in the Mammalian Aorta

Abstract

The presence of IgG Fc receptors in the tissue sections of aorta and aortic valves of man, ox and pig was demonstrated by means of hemadsorption of human and rabbit IgG antibody sensitized erythrocytes to these sections. C3b receptors in the tissue sections of aortic valves of these three mammals were also demonstrated by using sheep erythrocytes sensitized with rabbit IgM antibody which bound murine complement. 8 of 13 systemic lupus erythematosus sera and 2 of 19 other collagen disease sera were shown to be able to inhibit the adsorption of rabbit IgG antibody sensitized erythrocytes to the human aortic sections upon preincubation of the tissues with the pathologic sera. The amount of immune complexes in the ‘inhibition-positive’ sera was significantly higher than that in the negative sera.

Mechanisms involved in the binding of IgG immune complexes to sections of inflamed gingiva

“…The observation that the binding was abolished by treatment of tissue with cold ethanol is also consistent with the view that the adherence is caused by IgGFcR (Tonder & Thunold 1973, Kasukawa et al 1980. Free RF activity, on the other hand, can be demonstrated in sections of tissues fixed in ethanol for 18 h (Munthe & Natvig 1971, Malmstrom 1975.…”

“…Malmstrom (1975) using a similar technique reported no binding of aggregated IgG to ethanol-fixed gingival biopsy specimens. The report of Mackler et al (1978) also is at variance with the observations of several other investigators (Krogh & T0nder 1972, T0nder & Thunold 1973, Kasukawa, Okada & Igari 1980 who found that the exposure of tissues to ethanol destroys IgGFcR activity in various tissues.…”