Recherches Sur La Physiologie et la Pharmacologie Du Système Nerveux Autonome: XI.—Essai D'Identification Du Médiateur Cihimique Libéré Dans La Membrane Nictitante Du Chat Par L'Excitation Sympathique

Effect of Denervation on Enzymes in Iris and Blood Vessels

“…They found that the denervated membrane was regularly more sensitive than the normal membrane to adrenaline, noradrenaline and acetylcholine, but that both membranes were insensitive to other agents. They confirmed the evidence of Bacq and Fredericq (1935) that there are some cholinergic fibres in the sympathetic supply of the nictitating membrane. Thus the question arose whether the increased sensitivity of the denervated nictitating membrane to acetylcholine was due to a fall in cholinesterase.…”

The Use of the Rat's Isolated Seminal Vesicle for the Assay of Sympatholytic Drugs*

“…Drugs from the same chemical series show a similar degree of tissue fixation; the 2-haloalkylamines appear to attach themselves strongly to tissue receptors, whereas the benzo- (Clark, 1926(Clark, , 1927. Such a relationship also exists for the response to adrenaline and is in accord with results obtained on the rabbit's isolated uterus (Gaddum, 1926) and the cat's nictitating membrane (Rosenblueth, 1932;and Bacq and Fredericq, 1935). A sigmoid curve always results although a good portion of this is essentially linear (Fig.…”

Studies on the responses of the isolated nictitating membrane of the cat

“…Since the post-ganglionic nerve supply to the nictitating membrane of the cat is known to contain a cholinergic component (Bacq & Fredericq, 1935;Burn & Trendelenburg, 1954), the nerve fibres lying amongst the smooth muscle are probably a mixture of post-ganglionic adrenergic and cholinergic fibres, and one would expect both types of fibres to be excited by drugs such as nicotine and tetramethylammonium. The attempt to reveal excitation of cholinergic fibres by nicotine or tetramethylammonium was inconclusive.…”