Recherches sur le métabolisme des peroxydes d'esters d'acides gras

Dubouloz, P; Fondarai, J; Lagarde, Cédric

doi:10.1016/0006-3002(49)90108-0

Cited by 11 publications

(2 citation statements)

References 9 publications

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“…The purpose of the experiments reported in this paper was to identify the site of this mechanism which is even less understood than the mechanism by which lipoperoxide formation in tissues is prevented. DUBOULOZ et al (1949) studied the fate of orally ingested lipoperoxides in the digestive tract. They found a gradual disappearance in the course of some hours, roughly paralleling the course of fat absorption.…”

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confidence: 99%

On the Digestion and Absorption of Lipoperoxides

Glavind¹,

Tryding

1960

Acta Physiologica Scandinavica

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GLAVIND, J. and N. TRYDING. On the digestion and absorption of 1i)operoxides. Acta physiol. scand. 1960. 49. 97-102. -The purpose of the work was to study the fate of orally ingested peroxides. Lipoperoxides were given by mouth to rats with cannulated thoracic duct. No lipoperoxide could be found in the lymph. Pancreatic juice, bile, and lymph were shaken with lipoperoxides at suitable temperature and pH. At intervals free fatty acids, total lipoperoxide, and, after chromatographic separation on alumina, peroxide-containing esters and peroxide-containing free fatty acids were determined. Pancreatic juice splits lipoperoxides with the formation of peroxide-containing fatty acids, and generally also produces a decrease of total lipoperoxide. Bile and lymph alone have no effect on lipoperoxides. The results suggest that the essential site of the destruction of the lipoperoxides ingested with the food is the intestinal mucosa.The normal diet regularly contains a larger or smaller quantity of lipoperoxides (lipids containing peroxide-groups). On the other hand, the lipids from different parts of the organism only contain negligible amounts of peroxides. This general observation is confirmed by experiments. DUBOULOZ, FONDARAIand LACARDE (1949) fed large amounts of lipoperoxides to rats, but none could be recovered in the adipose tissue. We have made similar experiments with the same result. Such studies suggest the existence of a mechanism for the elimination

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confidence: 99%

On the Digestion and Absorption of Lipoperoxides

Glavind¹,

Tryding

1960

Acta Physiologica Scandinavica

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“…Nutritive Value or Toxicity of highly unsaturated Fatty Acids (3) Takashi KANEDA, Hisae SAKAI and Seinosuke Isxu…”

Section: Studies On the Nutritive Value Of Lipides--nlmentioning

confidence: 99%

Studies on the Nutritive Value of Lipides-XII

Kaneda¹,

Sakai²,

Ishii³

1954

NIPPON SUISAN GAKKAISHI

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Uptake of secondary autoxidation products of linoleic acid by the rat

Kanazawa

Natake

1985

Lipids

105

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Incorporation of secondary autoxidation products (SP) of linoleic acid into the rat body was investigated. Radioactive SP was administered orally to a group of 5 rats, and excretions of radioactive substances in feces, urine and respiration were measured and compared with excretions from rats fed linoleic acid and its hydroperoxides. The SP-fed group excreted 45% and the other groups about 10% of the administered radioactivity through feces. Urinary excretion accounted for 52% of activity ingested in the SP group and less than 30% in the other groups. The 14CO2 produced in each group was about 25% of the ingested activity. Incorporation of the radioactive substances of SP into tissues and organs was measured periodically after administration of a single dose. The radioactive substances accumulated in the liver between 12-24 hr after administration and accounted for 2.6% of the total amount given, the highest level of all tissues and organs. This accumulation led to an elevation of serum transaminase activities, an increase in hepatic lipid peroxide, as determined by thiobarbituric acid test, and a slight hypertrophy of liver (1.5-fold). Therefore, absorbed SP appeared to contribute to the deleterious condition of the liver.

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Recherches sur le métabolisme des peroxydes d'esters d'acides gras

Cited by 11 publications

References 9 publications

On the Digestion and Absorption of Lipoperoxides

On the Digestion and Absorption of Lipoperoxides

Studies on the Nutritive Value of Lipides-XII

Uptake of secondary autoxidation products of linoleic acid by the rat

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