Recipient and Donor Outcomes After Living-Donor Liver Transplant for Unresectable Colorectal Liver Metastases

Hernandez‐Alejandro, Roberto; Ruffolo, Luis I.; Sasaki, Kazunari; Tomiyama, Koji; Orloff, Mark S.; Pineda-Solís, Karen; Nair, Amit; Errigo, Jennie; Dokus, M. Katherine; Cattral, Mark S.; McGilvray, Ian D.; Ghanekar, Anand; Gallinger, Steven; Selzner, Nazia; Claasen, Marco; Burkes, R.; Hashimoto, Koji; Fujiki, Masato; Quintini, Cristiano; Estfan, Bassam; Kwon, Choon Hyuck David; Menon, Krishna; Aucejo, Federico; Sapisochín, Gonzalo

doi:10.1001/jamasurg.2022.0300

Cited by 72 publications

(56 citation statements)

References 25 publications

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“…Of great importance, the present review focused on HCC, but the concept is likely applicable to other cancers that also became indications of LT, like cholangiocarcinoma ( 67 ) or colorectal liver metastases (CRLMs) ( 68 ). The debate for these malignancies is even more intense and the room for improvement more consequent.…”

Section: Discussionmentioning

confidence: 99%

Is liquid biopsy the future commutator of decision-making in liver transplantation for hepatocellular carcinoma?

et al. 2022

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Liver transplant (LT) is the most favorable treatment option for patients with early stage hepatocellular carcinoma (HCC). Numerous attempts have been pursued to establish eligibility criteria and select HCC patients for LT, leading to various systems that essentially integrate clinico-morphological variables. Lacking of sufficient granularity to recapitulate the biological complexity of the disease, all these alternatives display substantial limitations and are thus undeniably imperfect. Liquid biopsy, defined as the molecular analysis of circulating analytes released by a cancer into the bloodstream, was revealed as an incomparable tool in the management of cancers, including HCC. It appears as an ideal candidate to refine selection criteria of LT in HCC. The present comprehensive review analyzed the available literature on this topic. Data in the field, however, remain scarce with only 17 studies. Although rare, these studies provided important and encouraging findings highlighting notable prognostic values and supporting the contribution of liquid biopsy in this specific clinical scenario. These results underpinned the critical and urgent need to intensify and accelerate research on liquid biopsy, in order to determine whether and how liquid biopsy may be integrated in the decision-making of LT in HCC.

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Section: Discussionmentioning

confidence: 99%

Is liquid biopsy the future commutator of decision-making in liver transplantation for hepatocellular carcinoma?

et al. 2022

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“…CRC is the third most common cancer worldwide, and more than 50% of patients will develop to colorectal cancer liver metastases due to the absence of early symptoms and untimely diagnosis (Hernandez-Alejandro et al, 2022). Surgical resection alone is regarded as the standard of care for patients with liver metastases, but the recurrence rates remain high (Nordlinger et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Hydrogen sulfide activatable metal-organic frameworks for Fluorescence Imaging-Guided Photodynamic Therapy of colorectal cancer

Huang²,

Wei³

et al. 2022

Front. Bioeng. Biotechnol.

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Photodynamic therapy (PDT) is a promising alternative and palliative therapeutic strategy for colorectal cancer (CRC). A novel photosensitizer with higher selectivity for CRC and fewer side effects is vital for clinical application. Given that the overexpression of hydrogen sulfide (H2S) in CRC, it is expected to provide a selective stimulus for activatable photosensitizers that in respond to the specific microenvironment. Herein, we report a novel development of metal-organic frameworks (MOFs) composed of meso-Tetra (4-carboxyphenyl) porphine (TCPP) and ferric ion (Fe3+) through a facile one-pot process. Experiments both in vitro and in vivo reveal that the MOF is capable of depredating in response to the high content of H2S in tumor microenvironment of CRC. Accompanying with the degradation and release of TCPP, the fluorescence and photosensitivity effect is switched from “off” to “on”, enabling the MOF to serve as a H2S activatable nano-photosensitizer for real-time fluorescence imaging-guided and targeted PDT of CRC.

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“…Canada lacks such a surplus, however. So, the Ajmera Transplant Center at Toronto General Hospital leveraged their positive experience with the use of living‐donor liver transplant (LDLT) for patients with hepatocellular carcinoma and low Model for End‐Stage Liver Disease scores to determine whether LDLT could be used as an effective treatment for patients with unresectable liver‐confined colorectal cancer metastases 1 …”

Section: Living‐donor Liver Transplant Successfully Treats Unresectab...mentioning

confidence: 99%

T Cells Prepare for a Test: Can They Tolerate a Donor Heart?

Pullen¹

2022

American Journal of Transplantation

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Recipient and Donor Outcomes After Living-Donor Liver Transplant for Unresectable Colorectal Liver Metastases

Abstract: This cohort study examines overall and recurrence-free survival outcomes in adult patients with liver-confined, unresectable colorectal cancer liver metastases who underwent a living-donor liver transplant.

Cited by 72 publications

References 25 publications

Is liquid biopsy the future commutator of decision-making in liver transplantation for hepatocellular carcinoma?

Is liquid biopsy the future commutator of decision-making in liver transplantation for hepatocellular carcinoma?

Hydrogen sulfide activatable metal-organic frameworks for Fluorescence Imaging-Guided Photodynamic Therapy of colorectal cancer

T Cells Prepare for a Test: Can They Tolerate a Donor Heart?

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