Recipient Sex Differences in Kidney Graft Survival Are Influenced by Donor Sex and Recipient Age

Morgan, Georgia; Goolam‐Mahomed, Zahrah; Hodson, James; Nath, Jay; Sharif, Adnan

doi:10.6002/ect.2020.0112

Cited by 4 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, the authors report on findings in support of our data with higher rates of death-censored graft loss rates in young female recipients of male kidneys compared to male recipients of similar age. While not reaching statistical significance, the authors note, much like our own observations, that these disparities gradually decreased with advanced recipient age ( 30 ).…”

Section: Clinical Relevance Of Biological Sex and Aging In Solid Orga...supporting

confidence: 60%

The combinatorial effect of age and biological sex on alloimmunity and transplantation outcome

Martin,

Xiao,

Welten

et al. 2024

Front. Transplant.

View full text Add to dashboard Cite

Both age and biological sex affect transplantation outcomes. We have recently shown in a large volume clinical analysis utilizing the SRTR data that graft survival is inferior in young female kidney transplant recipients. In this multi-factorial analysis, older female recipients presented with a trend towards improved transplant outcomes compared to both young female recipients and male recipients of any age. Those data supported by reports of those of others suggest that sex and age impact alloimmune responses both, individually and synergistically. Biological sex and hormone levels change throughout a lifetime with recognized effects on longevity in addition to an impact on the development and course of several disease preconditions. Detailed mechanisms of those sex and age-specific aspects have thus far been studied outside of transplantation. Effects on alloimmunity are largely unknown. Moreover, the combinatorial impact that both, biological sex and age have on transplant outcomes is not understood. Here, we summarize available data that analyze how age in combination with biological sex may shape alloimmune responses and affect transplant outcomes.

show abstract

Section: Clinical Relevance Of Biological Sex and Aging In Solid Orga...supporting

confidence: 60%

The combinatorial effect of age and biological sex on alloimmunity and transplantation outcome

Martin,

Xiao,

Welten

et al. 2024

Front. Transplant.

View full text Add to dashboard Cite

show abstract

“…Interestingly, this effect was reversed in the group that was 45 years and older. 56 Another study investigated the interaction between recipient sex and neighborhood poverty and reported that women from poor to middle-income neighborhoods had a significantly higher risk of graft loss compared to men following living donor kidney transplant. On the other hand, women from middle-income to rich neighborhoods had better patient survival compared to their male counterparts.…”

Section: Graft and Patient Survivalmentioning

confidence: 99%

“…found that while there was no difference in overall graft survival between sexes, outcomes varied at different age groups, with female recipients between 25 and 44 years old having significantly shorter graft survival than their male counterparts. Interestingly, this effect was reversed in the group that was 45 years and older 56 . Another study investigated the interaction between recipient sex and neighborhood poverty and reported that women from poor to middle‐income neighborhoods had a significantly higher risk of graft loss compared to men following living donor kidney transplant.…”

Section: Introductionmentioning

confidence: 99%

Sex and gender disparity in kidney transplantation: Historical and future perspectives

Salas

Chua²,

Rossi³

et al. 2022

Clinical Transplantation

View full text Add to dashboard Cite

Sex and gender disparity exist in various stages of kidney transplantation. Females were found to be less likely to be referred for kidney transplant, complete pretransplant evaluation, be placed on the waitlist, and receive a kidney transplant compared to their male counterparts. Interestingly, females comprise the majority of living kidney donors. This review explores the biological and psychosocial factors that contribute to sex and gender disparity in kidney transplantation and proposes ways to address the disparity.

show abstract

“…Donor-recipient sex mismatch has previously been correlated with poorer outcomes [16,17]. Although, it appears outcomes could be further modulated by age mismatches as well [18]. However, there is insufficient data on the histopathologic correlations with such outcome studies.…”

Section: Discussionmentioning

confidence: 99%

Novel Histopathologic and Ultrastructural Findings in Renal Allografts From Patients With Size and Age Mismatches: A Case Series

Lilley¹,

Picken²

2023

Cureus

View full text Add to dashboard Cite

While reports on the long-term pathology in mismatched allografts have been focused on the donor and recipient body surface area, evidence is emerging to support donor-recipient age difference as an additional prognostic factor. Most reports are based on pediatric recipients receiving older/bigger allografts. Here, we describe three cases with age mismatch including two cases of adult patients receiving pediatric allografts and a third case of a younger patient receiving an allograft from an older donor exhibiting findings not described in extant literature. Each of these cases exhibits unique changes seen in mismatched donorrecipient size/age post-transplant pathology. These non-rejection changes should be suspected in cases of donor-recipient size/age mismatch. In cases of allograft function decline, a full biopsy workup, including electron microscopy, should be considered.

show abstract

Recipient Sex Differences in Kidney Graft Survival Are Influenced by Donor Sex and Recipient Age

Cited by 4 publications

References 18 publications

The combinatorial effect of age and biological sex on alloimmunity and transplantation outcome

The combinatorial effect of age and biological sex on alloimmunity and transplantation outcome

Sex and gender disparity in kidney transplantation: Historical and future perspectives

Novel Histopathologic and Ultrastructural Findings in Renal Allografts From Patients With Size and Age Mismatches: A Case Series

Contact Info

Product

Resources

About