Reciprocal effects between microRNA-140-5p and ADAM10 suppress migration and invasion of human tongue cancer cells

Yue, Kai; Wang, Peng; Wu, Ling; Jiebing, Hao; Bian, Zhuan

doi:10.1016/j.bbrc.2014.02.032

Cited by 63 publications

(48 citation statements)

References 31 publications

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“…It has been reported that miR-140-5p plays a tumor suppressor in non-small cell lung cancer [9], tongue squamous cell carcinoma [10], hepatocellular carcinoma [11]. In lung cancer, miR-140-5p targeting MMD inhibits cell proliferation via suppressing MAPK signal pathway [12].…”

Section: Discussionmentioning

confidence: 99%

miR-140-5p inhibits ovarian cancer growth partially by repression of PDGFRA

Hong

Chen²,

et al. 2015

Biomedicine & Pharmacotherapy

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Section: Discussionmentioning

confidence: 99%

miR-140-5p inhibits ovarian cancer growth partially by repression of PDGFRA

Hong

Chen²,

et al. 2015

Biomedicine & Pharmacotherapy

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“…Error bars indicate SD. *P<0.05 suppression of ADAM10 by this microRNA (26,28). MiR-140 was characterized as a tumor suppressor because of its inhibiting the proliferation, migration and invasion of the cells by downregulating the IGF1R expression (27).…”

Section: Discussionmentioning

confidence: 99%

“…Compared with the normal tissues, the expression of miR-140 is downregulated in cell carcinomas including lung cancer cells [22][23][24][25]. The outcomes of recent studies have shown that miR-140s not only perform negative roles in tumor growth and metastasis but also suppress the migration and invasion of cancer cells by downregulating the expression of their special target genes [26][27][28]. In our study, we found that the expression of miR-140-3p was downregulated in NSCLC tissues, compared with their normal counterparts and miR-140-3p performed its negative role in cell growth, migration, and invasion, but positive role in cell apoptosis.…”

Section: Introductionmentioning

confidence: 99%

MiR-140-3p suppressed cell growth and invasion by downregulating the expression of ATP8A1 in non-small cell lung cancer

et al. 2015

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MicroRNAs (miRNAs) as a class of small noncoding RNA molecules regulate the expression of targeted gene. The dysregulation of microRNAs is reported to be involved in carcinogenesis and tumor progression. Here, we identified miR-140-3p as a downregulated microRNA in most cancer tissues including lung cancer tissues, compared with their normal counterparts. MiR-140-3p was observed to perform its tumor suppressor function via its inhibition on cell growth, migration and invasion but its induction of cell apoptosis. Furthermore, the growth of non-small-cell lung cancer (NSCLC) cells in nude mouse models were suppressed by overexpression of miR-140-3p. ATP8A1 was demonstrated as a novel direct target of miR-140-3p using a luciferase assay. The increased level of intracellular ATP8A1 protein attenuated the inhibitor role of miR-140-3p in the growth and mobility of NSCLC cell. A regulation mechanism of miR-140-3p for the development and progression of NSCLC through downregulating the ATP8A1 expression was first discovered in the present study.

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“…In one specific instance, overexpression of miR-210 and miR-214 was associated with aggressive progression of pediatric OS tumors [8]. miR-140 has been reported to participate in many cancers as a suppressor, such as liver tumor, breast cancer, and human tongue cancer [9][10][11]. Interestingly, miR-140 can also influence chemosensitivity to many anticancer agents [12].…”

Section: Introductionmentioning

confidence: 96%

Biological roles of microRNA-140 in tumor growth, migration, and metastasis of osteosarcoma in vivo and in vitro

Sun

et al. 2015

Tumor Biol.

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The objective of this study was to explore the biological roles of microRNA-140 (miR-140) in tumor growth, migration, and metastasis of osteosarcoma (OS) in vivo and in vitro. Between 2007 and 2014, 47 cases of OS samples and normal bone tissue samples adjacent to OS were selected from our hospital. Tissue biopsies from OS patients were used to measure miR-140 levels to obtain a correlation between clinicopathological features and miR-140 expression. In vitro, MG63 human osteosarcoma cells were divided into four groups: blank group, miR-140 mimic group, miR-140 inhibitor group, and negative control (NC; empty plasmid) group. qRT-PCR was used to detect miR-140 expression, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to detect cell proliferation, flow cytometry was used to detect cell cycle distribution, and scratch migration assay was used to detect cell migration. In vivo, the relative expression of miR-140 level in OS tissue was lower than that in the adjacent normal bone tissue. miR-140 expression is inversely correlated with tumor size, Enneking stage, and tumor metastasis. In vitro, compared with blank group and NC group, relative miR-140 expression was increased, cell proliferation was inhibited, cell population in G0/G1 phase was increased, cell population in G2/M phase and S phases and proliferation index (PI), and cell migration distance were decreased in the miR-140 mimic group, but the relative expression and all the cell indexes were found opposite trend in the miR-140 inhibitor group. In conclusion, in vivo and vitro findings provided evidence that miR-140 could inhibit the growth, migration, and metastasis of OS cells.

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Reciprocal effects between microRNA-140-5p and ADAM10 suppress migration and invasion of human tongue cancer cells

Cited by 63 publications

References 31 publications

miR-140-5p inhibits ovarian cancer growth partially by repression of PDGFRA

miR-140-5p inhibits ovarian cancer growth partially by repression of PDGFRA

MiR-140-3p suppressed cell growth and invasion by downregulating the expression of ATP8A1 in non-small cell lung cancer

Biological roles of microRNA-140 in tumor growth, migration, and metastasis of osteosarcoma in vivo and in vitro

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