Reciprocal t(14;19)(q32.3;q13.1) in a patient with B-cell lymphoma

Tanaka, Shinji; Nishigaki, H; Nakagawa, Hitoshi; Okuda, Tsukasa; Nishida, Kazuhiro; Tsuda, S; Imanishi, Hitoshi; Misawa, Shinichi; Kashima, Kei; Urata, Y.; Inazawa, Johji; Abe, Tatsuo; McKeithan, Timothy W.

doi:10.1016/0165-4608(90)90144-y

Cited by 24 publications

(15 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In keeping with the recent report of Huh et al (2007) and others (Bloomfield et al, 1983;Ueshima et al, 1985;Tanaka et al, 1990;McKeithan et al, 1997;Michaux et al, 1997;Au et al, 2002;Soma et al, 2006) we have confirmed its presence in atypical CLL and its association with large cell transformation.…”

supporting

confidence: 76%

t(14;19)(q32;q13) incidence and significance in B‐cell lymphoproliferative disorders

et al. 2008

View full text Add to dashboard Cite

supporting

confidence: 76%

t(14;19)(q32;q13) incidence and significance in B‐cell lymphoproliferative disorders

et al. 2008

View full text Add to dashboard Cite

“…This is in accordance with published data; the prevalence of t( 14; 19) assessed by cytogenetic and/or molecular analysis varies between 0 and 1.8% (Van Krieken et al, 1990;Raghoebier et al, 1991;Clark et al, 1992;Asou et al, 1993). Despite its low frequency, t(14;19) is typical for a subset of B-cell malignancies described as C L L (Bloomfield et al, 1983;Ueshima et al, 1985;Crossen et al, 1989;Busschots et al, 1991;Koduru et al, 1993;Ohno et al, 1993), N H L (Speaks et al, 1987;Tanaka et al, 1990;Sol6 et al, 1994), and acute biphenotypic leukemia with B-cell component (Carter et al, 1991). We found an analogous distribution: two cases of CLL, three cases of "mixed cell" type C L L (one CLL/PL and two C L L with heterogeneous population of B-cells), and one case of low-grade NHL.…”

Section: Molecular Investigationsmentioning

confidence: 95%

BCL3 rearrangement and t(14;19)(q32;q13) in lymphoproliferative disorders

Michaux

Mecucci

Stul

et al. 1996

Genes Chromosom. Cancer

View full text Add to dashboard Cite

“…5 The t (14;19) or bcl-3 gene rearrangement has been reported rarely in non-Hodgkin lymphomas, in approximately 35 cases, mostly in cases of chronic lymphocytic leukemia/small lymphocytic lymphoma, and less frequently in cases designated as follicular lymphoma, diffuse large B-cell lymphoma, Burkitt-like lymphoma, and one case of acute biphenotypic leukemia. [6][7][8][9][10][11][12] Although the t(14;19) is rare, BCL-3 expression has been shown in a few types of non-Hodgkin lymphoma not known to carry the t (14;19). For example, two recent studies have shown high levels of BCL-3 expression in ALKpositive anaplastic large-cell lymphoma.…”

mentioning

confidence: 99%

Immunohistochemical detection of BCL-3 in lymphoid neoplasms: a survey of 353 cases

et al. 2004

View full text Add to dashboard Cite

The bcl-3 gene at chromosome 19q13 encodes a member of the IjB family involved in regulating the NFjB pathway. Originally identified by its involvement in the rare t(14:19)(q32;q13), BCL-3 expression has never been analyzed in a wide variety of lymphomas. We assessed BCL-3 expression in 353 cases of non-Hodgkin lymphoma and Hodgkin lymphoma using formalin-fixed, paraffin-embedded tissue specimens, a monoclonal antibody specific for BCL-3, and immunohistochemical methods. Of 172 B-cell lymphomas, 10 (6%) were positive for BCL-3, including six of 23 (26%) diffuse large B-cell lymphoma, one of 17 (6%) small lymphocytic lymphoma, one of 26 (4%) follicular lymphoma, and two of 49 (4%) mantle cell lymphoma. All other B-cell neoplasms were negative, including marginal zone lymphoma (n ¼ 24, 11 extranodal, nine nodal, four splenic), Burkitt lymphoma (n ¼ 10), lymphoplasmacytic lymphoma (n ¼ 10), lymphoblastic lymphoma (n ¼ 8), and plasmacytoma (n ¼ 5). Of 111 T/NK-cell lymphomas, 25 (23%) were positive for BCL-3, including 13 of 40 (32%) anaplastic large-cell lymphoma, three of 10 (30%) angioimmunoblastic T-cell lymphoma, two of eight (25%) extranodal NK/T-cell lymphoma of nasal type, three of 12 (25%) mycosis fungoides, one of five (20%) enteropathy-type T-cell lymphoma, and two of 21 (10%) peripheral T-cell lymphoma unspecified. All other T-cell neoplasms were negative, including lymphoblastic lymphoma (n ¼ 6), prolymphocytic leukemia (n ¼ 6), and subcutaneous panniculitis-like T-cell lymphoma (n ¼ 3). Of 70 Hodgkin lymphomas, of all types, 29 (41%) were positive for BCL-3. The relatively high frequency of BCL-3 expression in some non-Hodgkin and Hodgkin lymphoma types raises the possibility that BCL-3 is involved in the pathogenesis of these tumors, and may be a target of new therapies.

show abstract

Reciprocal t(14;19)(q32.3;q13.1) in a patient with B-cell lymphoma

Cited by 24 publications

References 7 publications

t(14;19)(q32;q13) incidence and significance in B‐cell lymphoproliferative disorders

t(14;19)(q32;q13) incidence and significance in B‐cell lymphoproliferative disorders

BCL3 rearrangement and t(14;19)(q32;q13) in lymphoproliferative disorders

Immunohistochemical detection of BCL-3 in lymphoid neoplasms: a survey of 353 cases

Contact Info

Product

Resources

About