Reclassification of odontogenic keratocyst as tumour. Impact on the odontogenic tumours prevalence

Gaitán-Cepeda, LA; Quezada-Rivera, Daniel; Tenorio-Rocha, Fernando; Leyva-Huerta, E.R.

doi:10.1111/j.1601-0825.2009.01625.x

Cited by 66 publications

(78 citation statements)

References 18 publications

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“…This low frequency of malignant tumors is similar to those reported in others countries (7)(8)(9)(10)(11)(12)19), but it is different than those reported in China that present more than 5% of cases as malignant tumors (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29). We have observed a greater incidence of OTs in the female gender, result also found by Gaitán-Cepeda et al (30). However, other studies have found a greater incidence in male gender (18,21,22).…”

Section: Discussionsupporting

confidence: 69%

“…Corroborating with other studies (12,(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30), in our sample, benign tumors were prevalent. This low frequency of malignant tumors is similar to those reported in others countries (7)(8)(9)(10)(11)(12)19), but it is different than those reported in China that present more than 5% of cases as malignant tumors (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29).…”

Section: Discussionsupporting

confidence: 59%

“…Several retrospective studies of OTs published previously to the latest WHO classification (5) reported AMB and ODO being the most common tumors (7,13,19,29). However, the inclusion of KCOT has not only produced an increase in the frequency and prevalence of OTs, but also has modified the order of distribution of these tumors, making KCOT one of the most common OTs (18)(19)(20)(21)(22)30). OTs are uncommon lesions in the studied population and are represented mainly by the KCOT, AMB and ODO.…”

Section: Discussionmentioning

confidence: 99%

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Retrospective Study of 272 Odontogenic Tumors in a Brazilian Population

Silva

Tenório

Melo

et al. 2014

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Background: Odontogenic tumors (OTs) are considered important among oral lesions because of their clinicopathological heterogeneity, and variable biological behavior. This paper aims to determine the frequency and distribution of OTs, over a period of 10 years, at a public university in Northeastern Brazil and compare this data with previous reports. Material and Methods: We reviewed all cases of OTs from oral pathology laboratory of University of Pernambuco (UPE), from 2004 to 2014. Diagnoses were re-evaluated and the tumors were classified according to the latest (2005) World Health Organization Classification of Tumors. In addition, we searched in the English-language literature retrospective studies on OTs that used the same classification. Results: Within the total of 6028 oral biopsies, 289 (4.79%) were OTs. Of these, 287 (99.3%) were benign and 2 (0.7%) were malignant. The overall incidence was 31.1/million. Mandible-maxilla ratio was 2.5:1 and mean age 35 years. Keratocystic odontogenic tumor (KCOT) (34.6%) was the most frequent lesion, followed by ameloblastoma (AMB) (32.9%) and odontoma (ODO) (11.4%). Conclusions: OTs are uncommon neoplasms with geographic variation. Our clinicopathological features are according to literature. In the present study, KCOT was the most frequent one, showing that the new classification of OTs altered the distribution of these lesions and possibly made KCOT the most common OT observed in diagnostic services worldwide.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Retrospective Study of 272 Odontogenic Tumors in a Brazilian Population

Silva

Tenório

Melo

et al. 2014

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…14 KCOT is one of the most common odontogenic neoplasms of the jaw. In a recent analysis, Gaitán-Cepeda et al 15 point out that reclassification of P-OKC into a KCOT significantly changed the frequency distribution of odontogenic tumours making KCOTs the most frequent odontogenic tumour. The issue of appropriate treatment of KCOTs remains a subject of controversy.…”

mentioning

confidence: 98%

A systematic review of the recurrence rate for keratocystic odontogenic tumour in relation to treatment modalities

Kaczmarzyk¹,

Mojsa²,

Stypulkowska

2012

International Journal of Oral and Maxillofacial Surgery

141

114

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“…Due to the genetic features, tendency to recur, and high aggressiveness according to WHO classification, the parakeratinized variant of odontogenic keratocysts is classified as a benign odontogenic tumor (1)(2)(3).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of midkine expression in dentigerous cysts, odontogenic keratocysts and different types of ameloblastoma

Can

Tastekin²,

Yalta³

et al. 2013

TJPATH

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Objective: Midkine is a heparin-binding growth factor whose expression is increased in most tumors, namely ameloblastomas. This study aimed to compare Midkine expression in different odontogenic lesions. Material and Method:This analytical cross-sectional study was performed on 52 definitely diagnosed odontogenic lesions including 15 dentigerous cysts, 13 odontogenic keratocysts, and 17 unicystic and 5 multicystic ameloblastomas archived from 1997 to 2015. Midkine expression was examined in tissue samples through immunohistochemistry. The nonparametric Kruskal-Wallis and Mann-Whitney tests were run as appropriate (P < 0.05). Results:The frequency of Midkine expression was < 20% in 7.7%, 20-50% in 25%, and > 50 % in 67.3% of the samples, indicating significant differences among the groups (P = 0.002). Moreover, the expression intensity was strong in 63.5%, moderate in 23.1%, and weak in 13.5% of odontogenic lesion samples (P = 0.071). The total staining score was weak in 3.8%, moderate in 48.1%, and strong in 48.1% of the cells, displaying significant differences between the study groups in this regard (P = 0.043). Conclusion:Midkine can be considered as both a differentiating factor and a molecular-targeted therapy in odontogenic lesions. Yet, further studies are required to approve the role of this cytokine in different biological and pathological stages of the tumors.

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Reclassification of odontogenic keratocyst as tumour. Impact on the odontogenic tumours prevalence

Abstract: The redefinition of OKC as a tumour produced an increase in the frequency and prevalence of OT.

Cited by 66 publications

References 18 publications

Retrospective Study of 272 Odontogenic Tumors in a Brazilian Population

Retrospective Study of 272 Odontogenic Tumors in a Brazilian Population

A systematic review of the recurrence rate for keratocystic odontogenic tumour in relation to treatment modalities

Evaluation of midkine expression in dentigerous cysts, odontogenic keratocysts and different types of ameloblastoma

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