Recognition Memory for Complex Visual Discriminations Is Influenced by Stimulus Interference in Rodents With Perirhinal Cortex Damage

Gilbert, Paul E.; Kesner, Raymond P.

doi:10.1101/lm.64503

Cited by 58 publications

(39 citation statements)

References 41 publications

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“…Although accuracy was slightly lower in rats with hippocampal lesions, compared to controls, the learning of the groups was not statistically different. In contrast, rats with perirhinal cortex lesions were significantly impaired in utilizing a pattern separation function compared to both control and hippocampal-lesioned rats (Gilbert & Kesner, 2003). The results suggest that temporal pattern separation for objects is affected by stimulus interference in rodents and is mediated by the perirhinal cortex.…”

Section: Pattern Separation --Sensory-perceptual Attribute (Objects)mentioning

confidence: 66%

Neurobiological foundations of an attribute model of memory

Kesner¹

2013

CCBR

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Memory is a complex phenomenon due to a large number of potential interactions that are associated with the organization of memory at the psychological and neural system level. In this review article a tripartite, multiple attribute, multiple process memory model with different forms of memory and its neurobiological underpinnings is represented in terms of the nature, structure or content of information representation as a set of different attributes including language, time, place, response, reward value (affect) and visual object as an example of sensory-perception. For each attribute, information is processed in the event-based, knowledge-based, and rule-based memory systems through multiple operations that involve multiple neural underpinnings. Of the many processes associated with the event-based memory system, the emphasis will be placed on short-term or working memory and pattern separation. Of the many processes associated with the knowledgebased memory system, the emphasis will be placed on perceptual processes. Of the many processes associated with the rule-based memory system the emphasis will be on short-term or working memory and paired associate learning. For all three systems data will be presented to demonstrate differential neuroanatomical mediation and where available parallel results will be presented in rodents, monkeys and humans.

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Section: Pattern Separation --Sensory-perceptual Attribute (Objects)mentioning

confidence: 66%

Neurobiological foundations of an attribute model of memory

Kesner¹

2013

CCBR

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“…27 In our study, we used two behavioral tests of memory, a contextual fear conditioning test and NORT, to evaluate the effect of chronic hyponatremia on memory more definitively. The contextual fear conditioning test evaluates associative memory and NORT evaluates recognition memory, and they are mainly dependent on the hippocampus 34 and perirhinal cortex, [35][36][37] respectively. Therefore, it is suggested that chronic hyponatremia affects several kinds of memory and a broad range of brain areas related to memory processing.…”

Section: Discussionmentioning

confidence: 99%

Chronic Hyponatremia Causes Neurologic and Psychologic Impairments

Fujisawa

Sugimura

Takagi

et al. 2016

Journal of the American Society of Nephrology

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Hyponatremia is the most common clinical electrolyte disorder. Once thought to be asymptomatic in response to adaptation by the brain, recent evidence suggests that chronic hyponatremia may be linked to attention deficits, gait disturbances, risk of falls, and cognitive impairments. Such neurologic defects are associated with a reduction in quality of life and may be a significant cause of mortality. However, because underlying diseases such as adrenal insufficiency, heart failure, liver cirrhosis, and cancer may also affect brain function, the contribution of hyponatremia alone to neurologic manifestations and the underlying mechanisms remain unclear. Using a syndrome of inappropriate secretion of antidiuretic hormone rat model, we show here that sustained reduction of serum sodium ion concentration induced gait disturbances; facilitated the extinction of a contextual fear memory; caused cognitive impairment in a novel object recognition test; and impaired long-term potentiation at hippocampal CA3-CA1 synapses. In vivo microdialysis revealed an elevated extracellular glutamate concentration in the hippocampus of chronically hyponatremic rats. A sustained low extracellular sodium ion concentration also decreased glutamate uptake by primary astrocyte cultures, suggesting an underlying mechanism of impaired long-term potentiation. Furthermore, gait and memory performances of corrected hyponatremic rats were equivalent to those of control rats. Thus, these results suggest chronic hyponatremia in humans may cause gait disturbance and cognitive impairment, but these abnormalities are reversible and careful correction of this condition may improve quality of life and reduce mortality.

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“…Previous controls for difficulty in complex visual discriminations (Bussey et al, , 2003Gilbert and Kesner, 2003), oddity tasks (Buckley et al, 2001), and object recognition (Norman and Eacott, 2004) have used size, colors, shapes, or numbers of stimuli as a control for difficulty and have consistently revealed that simply increasing the difficulty of a task is not sufficient to produce PRh Oddity Preference Score Figure 8. Spontaneous oddity preference performance by control, PPRh, and PRh groups in experiment 4.…”

Section: Discussionmentioning

confidence: 99%

Perceptual Functions of Perirhinal Cortex in Rats: Zero-Delay Object Recognition and Simultaneous Oddity Discriminations

Bartko¹,

Winters²,

Cowell³

et al. 2007

J. Neurosci.

168

172

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The perirhinal cortex (PRh) is widely accepted as having an important role in object recognition memory in humans and animals. Contrary to claims that PRh mediates declarative memory exclusively, previous evidence suggests that PRh has a role in the perceptual processing of complex objects. In the present study, we conducted an examination of the possible role of PRh in perceptual function in rats. We examined whether bilateral excitotoxic lesions of PRh or PPRh (perirhinal plus postrhinal cortices) in the rat would cause deficits in a zero-delay object-recognition task and a simultaneous oddity discrimination task. Both of these tasks measured spontaneous (untrained, unrewarded) behavior, and the stimuli in these experiments were manipulated to produce varying levels of perceptual difficulty. As predicted by simulations using a computational model, rats with PPRh lesions were impaired in object recognition when the stimuli to be discriminated were manipulated to share many features in common. Furthermore, rats with PPRh and PRh lesions were impaired in a simultaneous oddity discrimination task when the stimuli to be discriminated were manipulated explicitly to be more perceptually similar. These findings provide support for the idea that PRh in the rat is important for the perceptual processing of complex objects, in addition to its well established role in memory.

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Recognition Memory for Complex Visual Discriminations Is Influenced by Stimulus Interference in Rodents With Perirhinal Cortex Damage

Cited by 58 publications

References 41 publications

Neurobiological foundations of an attribute model of memory

Neurobiological foundations of an attribute model of memory

Chronic Hyponatremia Causes Neurologic and Psychologic Impairments

Perceptual Functions of Perirhinal Cortex in Rats: Zero-Delay Object Recognition and Simultaneous Oddity Discriminations

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