Recognition of pemphigus antigens in drug-induced pemphigus vulgaris and pemphigus foliaceus

Brenner, Sarah; Bialy-Golan, Anat; Anhalt, Grant J.

doi:10.1016/s0190-9622(97)80273-3

Cited by 59 publications

(36 citation statements)

References 20 publications

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“…Pemphigus foliaceus morphology is characterised by upper spinous and/or granular layer involvement, while pempigus vulgaris clefts are located in a suprabasal location in the epidermis, folliculosebaceous and eccrine units (fig 11A). 3 91 93 – 96 Immunofluorescence findings mimic idiopathic pemphigus (fig 11A), but circulating antibodies are demonstrated more often in patients with non-thiol-induced pemphigus 3…”

Section: Predominantly Vesiculobullous Drug Eruptionsmentioning

confidence: 99%

Drug-induced cutaneous pathology

Ramdial¹,

Naidoo²

2009

J Clin Pathol

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Drug-induced cutaneous rashes, whether confined to the skin or part of a systemic disease, are characterised by a spectrum of inflammatory disease patterns that include perivascular dermatitis, nodular and diffuse dermatitis, vesiculobullous lesions, pustular eruptions, sclerodermoid reactions, vasculitis, folliculitis/perifolliculitis and panniculitis. While a single drug can elicit a range of reaction patterns, no reaction pattern is specific for a particular drug. Although the temporal link between initiation of drug therapy and the onset of the drug rash is critical to the diagnosis, drug reactions may also occur during the course of chronic drug ingestion. Clues to the drug-induced nature of the cutaneous eruption include the presence of overlapping histological reaction patterns and incongruent clinical and histopathological features. While eosinophils are an important tell-tale sign of a drug-induced reaction, they may also be conspicuous in skin rashes devoid of a drug association. Furthermore, eosinophils may be sparse or absent in some drug exanthems. Heightened awareness of the mimicry of a wide spectrum of cutaneous pathology by an ever-increasing range of therapeutic agents is pivotal to the diagnosis of drug-induced skin pathology.

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Section: Predominantly Vesiculobullous Drug Eruptionsmentioning

confidence: 99%

Drug-induced cutaneous pathology

Ramdial¹,

Naidoo²

2009

J Clin Pathol

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“…5 Oral drugs that trigger pemphigus foliaceus are the thiol and "masked thiol" compounds, such as penicillamine, captopril, penicillin, and piroxicam, as well as those with active amide and sulfur groups. 6,7 Since imiquimod lacks thiol, amide, and sulfur groups, it is unlikely that these mechanisms were involved.…”

Section: Report Of a Casementioning

confidence: 99%

Localized Pemphigus Foliaceus Induced by Topical Imiquimod Treatment

Lin¹,

Ladd²,

Powell³

et al. 2004

Arch Dermatol

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“…Emery et al (7) proved the pathogenetic role of autoantibodies against the 80-kd extracellular domain of desmoglein-1 in pemphigus foliaceus and pemphigus vulgaris. Several studies show that the autoantibody response is similar in both spontaneous and drug-induced disease (6,8). Predisposing factors are underlying disease (e.g.…”

Section: Discussionmentioning

confidence: 99%