2003
DOI: 10.1023/a:1025381921943
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Recombinant Glutamate Carboxypeptidase II (Prostate Specific Membrane Antigen—PSMA)—Cellular Localization and Bioactivity Analyses

Abstract: Glutamate Carboxypeptidase II (also known as Prostate Specific Membrane Antigen-PSMA) is an important marker in the diagnosis of prostate cancer, however, relatively little is known about its biochemical and structure-function characteristics. We have expressed mutant forms of PSMA and have started to address the roles of three putative domains of PSMA in its cellular localization and peptidase activity. Three mutants, a full-length recombinant PSMA (rPSMA-FL), one expressing only the proposed extracellular do… Show more

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Cited by 6 publications
(1 citation statement)
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“…2,3 The prostate specific membrane antigen (PSMA), also known as glutamate carboxypetidase II, N-acetyl-α-linked acidic dipeptidase I (Naaladase I) or folate hydrolase, is a type II zinc dependant integral membrane protein that is overexpressed in almost all prostate cancers. [4][5][6] PSMA catalyses the hydrolysis of N-acetylaspartylglutamate (NAAG) to generate glutamate and N-acetylaspartate (NAA), 7,8 the excessive production of which has been linked to a number of health issues including a variety of neurological diseases. 9,10 Primarily restricted to the prostate, PSMA expression levels in cancerous cells are approximately 1000 times higher than that of healthy tissue in other organs (such as those of the kidney and small intestine).…”
Section: Introductionmentioning
confidence: 99%
“…2,3 The prostate specific membrane antigen (PSMA), also known as glutamate carboxypetidase II, N-acetyl-α-linked acidic dipeptidase I (Naaladase I) or folate hydrolase, is a type II zinc dependant integral membrane protein that is overexpressed in almost all prostate cancers. [4][5][6] PSMA catalyses the hydrolysis of N-acetylaspartylglutamate (NAAG) to generate glutamate and N-acetylaspartate (NAA), 7,8 the excessive production of which has been linked to a number of health issues including a variety of neurological diseases. 9,10 Primarily restricted to the prostate, PSMA expression levels in cancerous cells are approximately 1000 times higher than that of healthy tissue in other organs (such as those of the kidney and small intestine).…”
Section: Introductionmentioning
confidence: 99%