Recombinant granulocyte-macrophage colony-stimulating factor in the treatment of indolent ulcers with Klippel-Trénaunay-Weber syndrome: a case report

Siddiqui, F.; Mokhashi, Moinuddin H.; Boathman, Abdullah

doi:10.1016/j.jpedsurg.2006.10.093

Cited by 9 publications

(7 citation statements)

References 15 publications

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“…In addition, wound closure occurred normally at a rate similar to the saline-treated control group. Several recent studies have reported that the local application of GM-CSF enhanced wound healing (Cianfarani et al, 2006;Mann et al, 2006;Siddiqui et al, 2007); however, there was no significant difference in the rate of decrease in neutrophil influx and wound closure between the experimental groups in our study. In the case of S. aureus-inoculated mice, it appears that sustained and continuous increase of neutrophil influx during the initial few days contributed to the efficient clearance of bacteria to a level that enabled normal wound healing.…”

Section: Discussioncontrasting

confidence: 90%

Dynamics of Neutrophil Infiltration during Cutaneous Wound Healing and Infection Using Fluorescence Imaging

Kim

Liu

Borjesson

et al. 2008

Journal of Investigative Dermatology

235

214

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Neutrophil influx is an early inflammatory response that is essential for the clearance of bacteria and cellular debris during cutaneous wounding. A non-invasive real-time fluorescence imaging technique was developed to examine the kinetics of enhanced green fluorescence protein-polymorphonuclear leukocyte (EGFP-PMN) influx within a wound. We hypothesized that infection or systemic availability would directly regulate the dynamics of EGFP-PMN recruitment and the efficiency of wound closure. Neutrophil recruitment increased dramatically over the first 24 hours from 10(6) at 4 hours up to a maximum of 5 x 10(6) EGFP-PMNs at 18 hours. A high rate of EGFP-PMN turnover was evidenced by approximately 80% decrease in EGFP signal within 6 hours. In response to wound colonization by Staphylococcus aureus or injection of GM-CSF, systemic PMNs increased twofold above saline control. This correlated with an increase in EGFP-PMN recruitment up to approximately 10(7) within the wound. Despite this effect by these distinct inflammatory drivers, wound closure occurred at a rate similar to the saline-treated control group. In summary, a non-invasive fluorescence-based imaging approach combined with genetic labeling of neutrophils provides a dynamic inner view of inflammation and the kinetics of neutrophil infiltration into the wounded skin over extended durations.

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Section: Discussioncontrasting

confidence: 90%

Dynamics of Neutrophil Infiltration during Cutaneous Wound Healing and Infection Using Fluorescence Imaging

Kim

Liu

Borjesson

et al. 2008

Journal of Investigative Dermatology

235

214

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“…40 Encouraging descriptions of the use of GM-CSF for rapid healing of ulcers have been reported. [41][42][43] Locally Fibrin sealants Blood plasma is cryoprecipitated to obtain fibrinogen.…”

Section: Tissue Healing and Growth Factorsmentioning

confidence: 99%

“…45 It has also been used for the treatment of indolent ulcers associated with congenital disease. 41 Another study showed that GM-CSF was required to ensure that newly formed tissue is of high quality. 46 Additionally, it has been shown that impairment of GM-CSF production can cause delayed healing or lead to chronic inflammation, which is an unfavorable situation for the host.…”

Section: Fgf Family (Fgf-1 and Fgf-2)mentioning

confidence: 99%

“…Encouraging descriptions of the use of GM‐CSF for rapid healing of ulcers have been reported 41‐43 . Locally applied rhGM‐CSF improved healing of chronic diabetic leg ulcers, 44 and GM‐CSF administration appears to enhance chronic wound repair 45 .…”

Section: Tissue Healing and Growth Factorsmentioning

confidence: 99%

“…Locally applied rhGM‐CSF improved healing of chronic diabetic leg ulcers, 44 and GM‐CSF administration appears to enhance chronic wound repair 45 . It has also been used for the treatment of indolent ulcers associated with congenital disease 41 . Another study showed that GM‐CSF was required to ensure that newly formed tissue is of high quality 46 .…”

Section: Tissue Healing and Growth Factorsmentioning

confidence: 99%

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Theoretical and Clinical Considerations for Autologous Blood Preparations: Platelet‐Rich Plasma, Fibrin Sealants, and Plasma‐Rich Growth Factors

Eskan

Greenwell

2011

Clin Adv Periodontics

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Introduction: Growth factors may play a prominent role in wound healing. Concentrating these mediators and applying them to healing osseous or soft tissue may accelerate the process and improve the quality of the healing tissues. Methods of collecting and concentrating autologous platelets have been developed. Platelet‐rich plasma (PRP) is a technique that concentrates platelets and releases their growth factors when applied to healing tissues. There are some positive data about the effects of PRP on hard‐ and soft‐tissue healing, but there is also some literature that shows minimal or no effect. Fibrin sealants undergo a different preparation procedure than PRP and tend to concentrate fibrinogen rather than platelets. They can be applied to either hard or soft tissue. Studies of these agents are also conflicting and some show positive results, whereas others show minimal effect. A third technique is plasma‐rich growth factors (PRGFs). Like PRP, this preparation concentrates platelets but differs from PRP in that no leukocytes are included. Studies support its use to improve hard‐ and soft‐tissue healing, but these articles are primarily case reports. Case Presentations: Pictures of two cases are shown in Figures 2 through 5. One shows the use of PRP with ridge augmentation, whereas the other demonstrates the use of PRP with root coverage. Conclusion: All of these agents, PRP, fibrin sealants, and PRGF, need additional study to determine the best indications to obtain a predictable wound healing benefit.

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Topically applied rhGM-CSF for the wound healing: A systematic review

Sun

Han

et al. 2011

Burns

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Recombinant granulocyte-macrophage colony-stimulating factor in the treatment of indolent ulcers with Klippel-Trénaunay-Weber syndrome: a case report

Cited by 9 publications

References 15 publications

Dynamics of Neutrophil Infiltration during Cutaneous Wound Healing and Infection Using Fluorescence Imaging

Dynamics of Neutrophil Infiltration during Cutaneous Wound Healing and Infection Using Fluorescence Imaging

Theoretical and Clinical Considerations for Autologous Blood Preparations: Platelet‐Rich Plasma, Fibrin Sealants, and Plasma‐Rich Growth Factors

Topically applied rhGM-CSF for the wound healing: A systematic review

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