Recombinant human erythropoietin offers neuroprotection through inducing endogenous erythropoietin receptor and neuroglobin in a neonatal rat model of periventricular white matter damage

Zhu, Lihua; Huang, Li; Wen, Quan; Wang, Ting; Qiao, Lixing; Jiang, Li

doi:10.1016/j.neulet.2017.03.024

Cited by 14 publications

(11 citation statements)

References 35 publications

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“…The optimized hypoxia-ischemia Rice-Vannucci rodent models can mimic many aspects of brain white matter injury in the preterm newborn. PND3 and PND6 rat HI models have been used to resemble PVL in the immature brain (Jantzie et al, 2015; Zhu et al, 2017). In a PND5 mouse HI model, hypoxia-ischemia induces a pattern of diffuse white and focal gray matter injury similar to that in preterm infants with PVL (Albertsson et al, 2014).…”

Section: Animal Models Of Neonatal Hi Brain Injurymentioning

confidence: 99%

Brain-immune interactions in perinatal hypoxic-ischemic brain injury

Concepcion

Meng

et al. 2017

Progress in Neurobiology

185

189

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Perinatal hypoxia-ischemia remains the primary cause of acute neonatal brain injury, leading to a high mortality rate and long-term neurological deficits, such as behavioral, social, attentional, cognitive and functional motor deficits. An ever-increasing body of evidence shows that the immune response to acute cerebral hypoxia-ischemia is a major contributor to the pathophysiology of neonatal brain injury. Hypoxia-ischemia provokes an intravascular inflammatory cascade that is further augmented by the activation of resident immune cells and the cerebral infiltration of peripheral immune cells response to cellular damages in the brain parenchyma. This prolonged and/or inappropriate neuroinflammation leads to secondary brain tissue injury. Yet, the long-term effects of immune activation, especially the adaptive immune response, on the hypoxic-ischemic brain still remain unclear. The focus of this review is to summarize recent advances in the understanding of post-hypoxic-ischemic neuroinflammation triggered by the innate and adaptive immune responses and to discuss how these mechanisms modulate the brain vulnerability to injury. A greater understanding of the reciprocal interactions between the hypoxic-ischemic brain and the immune system will open new avenues for potential immunomodulatory therapy in the treatment of neonatal brain injury.

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Section: Animal Models Of Neonatal Hi Brain Injurymentioning

confidence: 99%

Brain-immune interactions in perinatal hypoxic-ischemic brain injury

Concepcion

Meng

et al. 2017

Progress in Neurobiology

185

189

View full text Add to dashboard Cite

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“…In the case of the premature infant the term is most often used to refer primarily to death of pre-OLs, the principal cellular target in cerebral WMI of prematurity [14]. In experimental models of WMI, EPO has been shown to prevent pre-OL death [4][5][6][7]. However, it has been well-established in studies of WMI in experimental models and in human premature brain that after the initial pre-OL death, proliferation of oligodendroglial progenitors and replenishment of the pre-OL pool occur [3,15,16].…”

Section: Neuroprotection Vs Neurorestorationmentioning

confidence: 99%

“…Neurorestorative interventions are designed to counteract these critical dysmaturational events involving the pre-OL and, likely, secondarily, such neuronal-axonal structures as cerebral cortex and thalamus [18,23]. Indeed, EPO has been shown to promote pre-OL development in multiple models of WMI [1,5,7,24]. Promotion of angiogenesis and neurogenesis also may occur [1,25].…”

Section: Neuroprotection Vs Neurorestorationmentioning

confidence: 99%

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Commentary – Do the negative results of the PENUT trial close the book on erythropoietin for premature infant brain?

Volpe

2020

NPM

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“…In another study, Brines et al showed that the infarct area was smaller in the rat brain with EPO treatment and it had a cell-protecting effect [9]. It was also shown that when EPO is applied in the central nervous system after a stroke, it decreased apoptosis and brain edema [12]. EPO has direct and indirect effects on the nerve cell.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory efficiency of erythropoietin in sciatic nerve damage

Aydın¹

2018

Ann Clin Anal Med

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Aim: Peripheral nerve injuries are the major health problem in the world. Several neurotrophic agents have been evaluated for their efficacy in nerve injury. We aimed to compare the effects of erythropoietin (EPO), known to have neuroprotective, neuroregenerative and anti-inflammatory properties like gabapentin, on the sciatic nerve in experimental crush injury to the sciatic nerve in rats. Material and Method: We classified four groups for this study. Aneurysm clips were used for the sciatic nerve crush injury for trauma groups. Sciatic nerve and blood samples were taken for the experimental procedures. ELISA method was used to evaluate the tissue. Results: Average values of IL-1β and TNF-α levels of the groups and the relationship between the groups are presented. After EPO and gabapentin treatment, IL-1β levels were significantly lower in the trauma group. TNF-α levels were statistically significantly higher in the trauma group than in other groups. According to the EPO and gabapentin treatment, TNF-α levels were significantly lower than those in the trauma group. Discussion: In this study, the effects of EPO and gabapentin on the rat sciatic nerve injury were examined by biochemical methods. EPO is a drug that has an advantage of the treatment of anemia and used for the nerve damage in the experimental studies. We suggest that the EPO has beneficial effects on the trauma models with the blood loss and the nerve damage.

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Recombinant human erythropoietin offers neuroprotection through inducing endogenous erythropoietin receptor and neuroglobin in a neonatal rat model of periventricular white matter damage

Cited by 14 publications

References 35 publications

Brain-immune interactions in perinatal hypoxic-ischemic brain injury

Brain-immune interactions in perinatal hypoxic-ischemic brain injury

Commentary – Do the negative results of the PENUT trial close the book on erythropoietin for premature infant brain?

Anti-inflammatory efficiency of erythropoietin in sciatic nerve damage

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