Recombinant Vaccine–Derived Poliovirus in Madagascar

Rousset, Dominique; Rakoto-Andrianarivelo, Mala; Razafindratsimandresy, Richter; Randriamanalina, Bakolalalo; Guillot, Sophie; Balanant, Jean; Mauclère, Philippe; Delpeyroux, Françis

doi:10.3201/eid0907.020692

Cited by 123 publications

(133 citation statements)

References 6 publications

Supporting

Mentioning

122

Contrasting

Unclassified

Order By: Relevance

“…These approaches combine the ability to provide sufficient immunostimulation, as well as targeting of CD8 ϩ T cell immunity. Of these approaches, live vectors come with the risk of reconversion to virulence (53) and DNA vaccines often require either high doses or special delivery approaches for sustained immunity (54). Liposomes composed of conventional ester lipids have been considered for T cell vaccine development, but often require a codelivered immunostimulant for sufficient augmentation of innate immunity (55,56).…”

Section: Discussionmentioning

confidence: 99%

Rapid Clonal Expansion and Prolonged Maintenance of Memory CD8+ T Cells of the Effector (CD44highCD62Llow) and Central (CD44highCD62Lhigh) Phenotype by an Archaeosome Adjuvant Independent of TLR2

Krishnan

Gurnani

Dicaire

et al. 2007

The Journal of Immunology

View full text Add to dashboard Cite

Vaccines capable of eliciting long-term T cell immunity are required for combating many diseases. Live vectors can be unsafe whereas subunit vaccines often lack potency. We previously reported induction of CD8+ T cells to Ag entrapped in archaeal glycerolipid vesicles (archaeosomes). In this study, we evaluated the priming, phenotype, and functionality of the CD8+ T cells induced after immunization of mice with OVA-Methanobrevibacter smithii archaeosomes (MS-OVA). A single injection of MS-OVA evoked a profound primary response but the numbers of H-2KbOVA257–264-specific CD8+ T cells declined by 14–21 days, and <1% of primarily central phenotype (CD44highCD62Lhigh) cells persisted. A booster injection of MS-OVA at 3–11 wk promoted massive clonal expansion and a peak effector response of ∼20% splenic/blood OVA257–264-specific CD8+ T cells. Furthermore, contraction was protracted and the memory pool (IL-7Rαhigh) of ∼5% included effector (CD44highCD62Llow) and central (CD44highCD62Lhigh) phenotype cells. Recall response was observed even at >300 days. CFSE-labeled naive OT-1 (OVA257–264 TCR transgenic) cells transferred into MS-OVA-immunized recipients cycled profoundly (>90%) within the first week of immunization indicating potent Ag presentation. Moreover, ∼25% cycling of Ag-specific cells was seen for >50 days, suggesting an Ag depot. In vivo, CD8+ T cells evoked by MS-OVA killed >80% of specific targets, even at day 180. MS-OVA induced responses similar in magnitude to Listeria monocytogenes-OVA, a potent live vector. Furthermore, protective CD8+ T cells were induced in TLR2-deficient mice, suggesting nonengagement of TLR2 by archaeal lipids. Thus, an archaeosome adjuvant vaccine represents an alternative to live vectors for inducing CD8+ T cell memory.

show abstract

Section: Discussionmentioning

confidence: 99%

Rapid Clonal Expansion and Prolonged Maintenance of Memory CD8+ T Cells of the Effector (CD44highCD62Llow) and Central (CD44highCD62Lhigh) Phenotype by an Archaeosome Adjuvant Independent of TLR2

Krishnan

Gurnani

Dicaire

et al. 2007

The Journal of Immunology

View full text Add to dashboard Cite

show abstract

“…Aussi, une attention particulière a-t-elle été portée à la surveillance dans le REIP, avec la mise en place dès 1988 de programmes complémentaires comprenant des tests molécu-laires visant à surveiller la dérive des souches vaccinales [10]. C'est grâce à ces tests que la résurgence de cas de poliomyélite à Madagascar en 2001 a pu être associée à la présence de cPVDV [11,12]. (Figure 2).…”

Section: Les Vaccins Contre La Poliomyélite Paralytiqueunclassified

Éradication de la poliomyélite et émergence de poliovirus pathogènes dérivés du vaccin

Delpeyroux

Colbère-Garapin

Razafindratsimandresy

et al. 2013

Med Sci (Paris)

Self Cite

View full text Add to dashboard Cite

“…Dix épidémies de ce genre ont été détectées ces dernières années essentiellement dans des pays en voie de développement où la poliomyélite due au virus sauvage avait disparu depuis plusieurs années [3,4]. Ainsi deux épidé-mies de poliomyélite provoquées par des VDPV ont été rapportées en 2001-2002 et 2005, à Madagascar alors qu'aucun cas de maladie due au poliovirus sauvage n'avait été détecté dans l'île depuis 1998 [5,6].…”

Section: La Famille Des Entérovirusunclassified