Recombination in JXA1-R vaccine and NADC30-like strain of porcine reproductive and respiratory syndrome viruses

Liu, Jian-Kui; Zhou, Xia; Zhai, Junqiong; Wei, Cheng; Dai, Ailing; Yang, Xiaoyan; Man-lin, Luo

doi:10.1016/j.vetmic.2017.04.017

Cited by 51 publications

(46 citation statements)

References 45 publications

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“…Compared with the other PRRSV lineages in China, NADC30-like strains show more recombination possibilities and pathogenic diversity (Table 2 ). There are several reports about the recombination of NADC30-like strains including NADC30 with HP-PRRSV [ 24 , 46 – 48 ], NADC30 with vaccine strain (TJM-like, JXA1-P80) [ 49 – 51 ] and with classical PRRSV (CH-1a, VR2332) [ 48 , 52 ]. Besides, lineage 8 and lineage 3 also display different degrees of recombination [ 53 , 54 ].…”

Section: The Epidemic Of Prrsv-2 In Chinamentioning

confidence: 99%

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The prevalent status and genetic diversity of porcine reproductive and respiratory syndrome virus in China: a molecular epidemiological perspective

Guo

Chen

et al. 2018

Virol J

191

148

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Porcine reproductive and respiratory syndrome virus (PRRSV) has been epidemic more than 30 years in America and 20 years in China. It is still one of the most important causative agents to the worldwide swine industry. Here, we systematically analyzed the prevalence status of PRRSV in China by a molecular epidemiological perspective. Now both PRRSV-1 and PRRSV-2 are circulating and approximately more than 80% of pig farms are seropositive for PRRSV. For PRRSV-2, there are four lineages (lineage 1, lineage 3, lineage 5, lineage 8) circulating in the fields. Lineage 8 (CH-1a-like) and lineage 5 (BJ-4-like) appeared almost at the same time during 1995-1996. Notably, BJ-4 shares 99.6% and 99.8% identity with VR2332 and RespPRRS MLV, respectively. It means that lineage 5 is likely to be imported from America. Now highly pathogenic PRRSV (HP-PRRSV) which was considered to be evolved from local diversity of lineage 8 strains is predominant with different variants. Lineage 3 appeared in 2010 which is mainly sporadic in south of China. Lineage 1, also known as NADC30-like strains in China, has been prevalent since 2013 and leads to PRRS pandemic again. For PRRSV-1, although sporadic at present, more than 9 provinces/regions have been reported. All the circulating strains belong to subtype I. It should be paid more attention since there are no vaccines available. Our analysis would help to deeply understand the prevalent status of PRRSV in China and provide useful information for prevention and control of porcine reproductive and respiratory syndrome (PRRS).

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Section: The Epidemic Of Prrsv-2 In Chinamentioning

confidence: 99%

“…For the virulence difference, some NADC30-like strains (JL580, FJ1402 etc.) show high pathogenicity comparable with HP-PRRSV [ 24 , 47 , 51 ]. Some NADC30-like strains (TJnh1501, HNjz15 etc.)…”

Section: The Epidemic Of Prrsv-2 In Chinamentioning

confidence: 99%

The prevalent status and genetic diversity of porcine reproductive and respiratory syndrome virus in China: a molecular epidemiological perspective

Guo

Chen

et al. 2018

Virol J

191

148

View full text Add to dashboard Cite

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“…Independent evolution [12], transmission among Asian countries, introduction of novel PRRSV strains from outside Asia [13,14] and recombination between PRRSV strains [15] were all involved. Moreover, use of PRRS modified live virus (MLV) vaccines could also impact PRRSV genetic variation and the ongoing genetic changes of PRRSV [16] .…”

Section: Prrsvmentioning

confidence: 99%

Major swine viral diseases: an Asian perspective after the African swine fever introduction

2020

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Asia is a major pig producer of the world, and at present, African swine fever virus (ASFV) continues to significantly impact the Asian pig industry. Since more than 50% of the world's pig population is in Asia, ASFV outbreaks in Asia will affect the global pig industry. Prior to the introduction of ASF, several outbreaks of major swine viruses occurred in Asia over the last two decades, including porcine reproductive and respiratory syndrome virus (PRRSV), porcine epidemic diarrhea virus (PEDV) and foot and mouth disease virus (FMDV). The rapid spreading of those viruses throughout Asia involve many factors such as the various pig production systems and supply chains ranging from backyard to intensive industrial farms, animal movement and animal product trading within and among countries, and consumer behaviors. ASF has notoriously been known as a human-driven disease. Travelers and international trading are the major ASFV-carriers for the transboundary transmission and introduction to naïve countries. Globalization puts the entire pig industry at risk for ASF and other infectious diseases arising from Asian countries. Disease control strategies for the various pig production systems in Asia are challenging. In order to ensure future food security in the region and to prevent the deleterious consequences of ASF and other major viral disease outbreaks, disease control strategies and production systems must be improved and modernized.

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“…However, vaccination against PRRSV infection has achieved limited success, primarily due to the high genetic diversity of the virus [9,10,22,29]. In addition to genetic mutation, PRRSV genetic diversity is also generated by recombination among different strains, including vaccine strains [7,18,23,30,33,37]. Importantly, commercial vaccines cannot provide complete protection against heterologous PRRSV infection [1,21].…”

Section: Introductionmentioning

confidence: 99%

Isobavachalcone inhibits post-entry stages of the porcine reproductive and respiratory syndrome virus life cycle

et al. 2018

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Porcine reproductive and respiratory syndrome virus (PRRSV) is a pathogen of great economic significance that impacts the swine industry globally. Since the first report of a porcine reproductive and respiratory syndrome (PRRS) outbreak, tremendous efforts to control this disease, including various national policies and plans incorporating the use of multiple modified live-virus vaccines, have been made. However, PRRSV is still a significant threat to the swine industry, and new variants continually emerge as a result of PRRSV evolution. Several studies have shown that pandemic PRRSV strains have enormous genetic diversity and that commercial vaccines can only provide partial protection against these strains. Therefore, effective anti-PRRSV drugs may be more suitable and reliable for PRRSV control. In this study, we observed that isobavachalcone (IBC), which was first isolated from Psoralea corylifolia, had potent anti-PRRSV activity in vitro. Although many biological activities of IBC have been reported, this is the first report describing the antiviral activity of IBC. Furthermore, after a systematic investigation, we demonstrated that IBC inhibits PRRSV replication at the post-entry stage of PRRSV infection. Thus, IBC may be a candidate for further evaluation as a therapeutic agent against PRRSV infection of swine in vivo.

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Recombination in JXA1-R vaccine and NADC30-like strain of porcine reproductive and respiratory syndrome viruses

Cited by 51 publications

References 45 publications

The prevalent status and genetic diversity of porcine reproductive and respiratory syndrome virus in China: a molecular epidemiological perspective

The prevalent status and genetic diversity of porcine reproductive and respiratory syndrome virus in China: a molecular epidemiological perspective

Major swine viral diseases: an Asian perspective after the African swine fever introduction

Isobavachalcone inhibits post-entry stages of the porcine reproductive and respiratory syndrome virus life cycle

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