Recommendations for the management of comorbidity in hidradenitis suppurativa

Daudén, E.; Lázaro, Pablo; Aguilar, M.A.; Blasco, Antonio Javier; Suárez, Carmen; Marín, Isabel González‐Gascón y; Queiró, Rubén; Bassas-Vila, J.; Martorell, A.; Garcı́a-Campayo, Javier

doi:10.1111/jdv.14517

Cited by 50 publications

(44 citation statements)

References 63 publications

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“…It is still uncertain whether in HS patients anemia is related to chronic causes or it is due to other factors at play [24]. However, the association between HS and anemia was first reported almost 50 years ago due to the chronic inflammatory process [1, 25, 26]. This condition might be aggravated by significant blood loss via sanguineous drainage from HS fistulas, also contributing to the development or preservation of anemia and could give rise to the fatigue that is often attributed to the psychological impact of the disease [1, 26-28].…”

Section: Discussionmentioning

confidence: 99%

“…The skin is a very important organ for adequate psychosocial functioning, since it is the largest and most visible part of the body [26]. Several studies have mentioned not only physical but also socioeconomic disabilities resulting from HS (work, family, sexual relations, emotional wellbeing, etc.)…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have mentioned not only physical but also socioeconomic disabilities resulting from HS (work, family, sexual relations, emotional wellbeing, etc.) [10, 26, 29, 30]. HS may lead to work inability and absences from school [9, 27].…”

Section: Discussionmentioning

confidence: 99%

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A Retrospective Cohort Study on Patients with Hidradenitis Suppurativa

et al. 2018

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Background: Hidradenitis suppurativa (HS) is one of the most distressing conditions observed in dermatology and has a substantial negative effect on the quality of life of affected persons. Objectives: The aim of this study was to evaluate different treatment strategies in patients with HS. Methods: In a retrospective cohort, all patients with HS (July 2015 to March 2017) were reviewed. Collected data consisted of patients’ demographics, clinical characteristics, psychosocial situation, and previous and current treatments. In addition, therapy response to the most recent prescribed treatments was assessed. Results: 102 patients (38 females, 64 males; median age 37.5 years) were included in this study. 68.4% of patients had BMI ≥25, and 76.5% of patients were current smokers. Hurley stages I, II, and III were detected in 13.5, 53.1, and 33.3% of patients, respectively. The most commonly administered treatments were surgery (67.6%), nonantibiotic topical therapies (72.5%), antibiotic topical therapies (55.9%), systemic antibiotics (88.2%), and biologics in 11.8% of the patients. 84.6% of the patients showed a response (27.5 and 47.1% partial and complete response, respectively) to the treatments. Conclusion: HS as a chronic, recurrent inflammatory skin disease is associated with smoking and obesity. Application of systemic antibiotics is the most frequent treatment strategy for this disease. However, surgical intervention seems to be the most effective treatment strategy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Retrospective Cohort Study on Patients with Hidradenitis Suppurativa

et al. 2018

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“…HS is considered a systemic inflammatory disease associated with other comorbidities such as metabolic syndrome, chronic intestinal diseases, and depression [6-8]. Furthermore, syndromic forms of HS have been described and their clinical behavior appears to be more severe, recalcitrant to treatment, and associated with a poorer quality of life compared to the nonsyndromic form [9].…”

Section: Discussionmentioning

confidence: 99%

“…Although the pathogenesis is complex and not yet clear, genetic susceptibility, mechanical stress, obesity, smoking, and hormonal factors are recognized risk factors associated with the development or worsening of HS [6, 7]. Emerging evidence suggests that HS is associated with other comorbidities [8], while data concerning the coexistence of HS and Down syndrome (DS) are scarce [9-11]. …”

Section: Introductionmentioning

confidence: 99%

Hidradenitis Suppurativa Associated with Down Syndrome Is Characterized by Early Age at Diagnosis

Giovanardi¹,

Chiricozzi

Bianchi

et al. 2018

Dermatology

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Background/Aims: The association between hidradenitis suppurativa (HS) and multiple comorbidities has been widely investigated but data about the coexistence of Down syndrome (DS) are scarce. We sought to evaluate the prevalence of DS among a population of HS patients and assess their clinical features. Methods: We collected demographic and clinical data of patients affected with HS referred to three Italian outpatient dermatology clinics. Results: A total of 257 HS patients were enrolled, 62% females and 38% males (mean age [±SD]: 23.3 ± 10.7 years); 9 of the 257 patients (3.5%), 7 females and 2 males, had concomitant HS and DS. The patients with DS and HS had a significantly earlier age of onset (mean age: 14.3 ± 3.6 vs. 23.4 ± 12.31 years; p = 0.029), a significantly younger age at diagnosis (mean age: 21.1 ± 11.1 vs. 31.8 ± 13.5 years; p = 0.015), and were significantly younger (mean age: 23.3 ± 10.7 vs. 34.6 ± 13.07 years; p = 0.005). No significant differences about other clinical data were found between the two groups. Conclusion: The prevalence of DS in HS patients corresponds to a not negligible 3.5% of cases, who experienced an onset of HS at a younger age compared to patients with HS only.

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Comorbidities in Autoimmune Skin Diseases

2018

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It may provide deeper insight into the pathomechanisms of both autoimmune skin diseases and their comorbidities and yield valuable suggestions for screening techniques for additional comorbidities that might be integrated into clinical practice. Dermatologists-and in some countries rheumatologists-are most likely be the clinicians who make the diagnosis of many autoimmune diseases.Better awareness about the risk of associated comorbidities could be conducive to both an improved management of patients and to an in-depth understanding of the molecular mechanisms of disease. More epidemiological data are necessary, and systematic reviews on comorbidities should be performed and published regularly to increase this awareness. A website dedicated to comorbidities in dermatology might contribute to this work.

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Recommendations for the management of comorbidity in hidradenitis suppurativa

Abstract: The application of these recommendations will facilitate the dermatologist practice and benefit HS patients' health and quality of life.

Cited by 50 publications

References 63 publications

A Retrospective Cohort Study on Patients with Hidradenitis Suppurativa

A Retrospective Cohort Study on Patients with Hidradenitis Suppurativa

Hidradenitis Suppurativa Associated with Down Syndrome Is Characterized by Early Age at Diagnosis

Comorbidities in Autoimmune Skin Diseases

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