Recommendations for the registration of drugs used in the treatment of osteoarthritis: an update on biochemical markers

Vignon, E; Garnero, Patrick; Delmas, Pierre D.; Avouac, Bernard; Bettica, Paolo; Boers, Maarten; Ehrich, Elliot W.; Mackillop, N.; Rovati, Lucio C.; Serni, U; Spector, Tim D.; Reginster, Jean‐Yves

doi:10.1053/joca.2000.0387

Cited by 32 publications

(25 citation statements)

References 33 publications

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“…Therefore, for efficient monitoring, more sensitive and feasible methods must be developed. Several biochemical markers (biomarkers) have been established and have greater reliability and sensitivity than radiographs for the early diagnosis or prognosis of Oa (18). Furthermore, such biomarkers are useful for evaluating the actions of disease-modifying drugs as they specifically reflect changes in the metabolism of cartilage and related tissues (19).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the effects of a supplementary diet containing chicken comb extract on symptoms and cartilage metabolism in patients with knee osteoarthritis

Nagaoka

Nabeshima²,

Murakami³

et al. 2010

Experimental and Therapeutic Medicine

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Abstract. We aimed to investigate whether a supplementary diet containing chicken comb extract (ccE) rich in hyaluronic acid (ha) has an effect on pain and other symptoms, as well as cartilage type ii collagen (cii) metabolism in patients with knee osteoarthritis (Oa). a randomized double-blind placebo-controlled study was conducted in 43 subjects with knee Oa (Kellgren/lawrence grade, mainly 1-2) comprising 22 patients receiving concurrent exercise therapy (Et) and 21 without Et (referred as Et-receivers and Et-unreceivers, respectively). Subjects were randomized to a ccE-containing diet (active diet) group administered a dose of 1,800 mg/day (containing 630 mg of ccE and approximately 60 mg of ha) and a placebo group, and the intervention was continued for 16 weeks. Symptomatic efficacy was evaluated based on the Japanese Orthopaedic association clinical trials response criteria (JOa response criteria) and visual analog scales (vaS) before (baseline) and during the intervention. to further examine its effect on cii metabolism, the levels of two degradation biomarkers (ctx-ii and c2c) and one synthesis biomarker (cpii) were measured using urine or serum samples. nineteen subjects (10 Et-receivers and 9 Et-unreceivers) in the active diet group and 21 subjects (10 Et-receivers and 11 ET-unreceivers) in the placebo group were finally included in the study. compared to the baseline, subscale scores of the JOa response criteria, i.e., 'pain/walking function', 'pain/step-up and -down function' and 'aggregate total symptoms' were more intensely improved in the active diet group than in the placebo group. moreover, subgroup analyses of ET-receivers and ET-unreceivers indicated that significant improvements were restricted to Et-receivers of the active diet group. Furthermore, vaS assessment indicated that the 'pain on pressing' subscale was significantly improved in Et-receivers of the active diet group. in addition, analysis of cii biomarkers revealed that serum c2c and cpii levels, but not the urinary ctx-ii level, were increased in the active diet group. notably, both urinary ctx-ii/serum cpii and serum c2c/serum cpii ratios were reduced in the active diet group (particularly Et-unreceivers), suggesting that cii synthesis was relatively increased compared to cii degradation in the active diet group. Finally, no diet-related side effects were observed. the ccE-containing diet is likely to be effective in relieving symptoms in patients with knee Oa. in addition, it has the potential to improve the balance of cii degradation/ synthesis in knee Oa.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the effects of a supplementary diet containing chicken comb extract on symptoms and cartilage metabolism in patients with knee osteoarthritis

Nagaoka

Nabeshima²,

Murakami³

et al. 2010

Experimental and Therapeutic Medicine

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“…This meeting was organized by the Group for the Respect of Ethics and Excellence in Science (GREES). This nonprofit organization has expertise in literature research and in expert consensus meetings [36][37][38][39][40][41][42][43][44].…”

Section: Methodsmentioning

confidence: 99%

The need for a transparent, ethical, and successful relationship between academic scientists and the pharmaceutical industry: a view of the Group for the Respect of Ethics and Excellence in Science (GREES)

Bruyère

Kanis

Ibar-Abadie³

et al. 2010

Osteoporos Int

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“…They reflect cartilage breakdown and synthesis, bone turnover, and synovial inflammation. Some potential markers of OA according to their origin are shown in Table 1 [9]. Cartilage degradation in OA can be detected assaying type II collagen degradation and proteoglycan degradation products [10].…”

Section: Clinical Usage Of Biochemical Markers In Oamentioning

confidence: 99%

“…Recent studies have shown that CTX-II was the most predictive marker of the progression of joint damage in patients with OA [18,19,20]. Garnero et al (2001) analyzed the relationship between the bone, cartilage and synovial markers and, disease activity and the severity of joint destruction [18]. The following biochemical markers were measured in both knee OA patients and healthy individuals: for bone, serum osteocalcin, serum and urinary C-telopeptide of type I collagen (CTX-I); for cartilage, urinary CTX-II, serum COMP, serum YKL-40; for synovium, urinary Glc-Gal-PYD, serum type III collagen Npropeptide (PIIINP), serum hyaluronic acid (HA); and for inflammation serum C-reactive protein.…”

Section: Clinical Usage Of Biochemical Markers In Oamentioning

confidence: 99%

Assessment of Disease Activity and Progression of Osteoarthritis With Using Molecular Markers of Cartilage and Synovium Turnover

Ofluoğlu¹,

Ofluoğlu²

2005

CRR

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Osteoarthritis (OA) is the most common joint disease, which is characterized by cartilage loss and concomitant alteration of synovium and subchondral bone metabolism. Pain and stiffness in the affected joints are the main complains. It also causes physical functional impairment. The measurement of joint space width by plain radiography is currently established method for assessing the progression of the disease. This method however has some limitations. The most important issue is to determine early OA before significant joint damage has occurred. When there is radiological evidence of OA, significant joint damage has often already occurred. Therefore, there is need for noninvasive methods that can be repeated and have better sensitivity than plain radiography to identify patients at high risk for destructive OA and monitoring drug efficacy.Molecular markers are released into biological fluids during tissue biosynthesis and turnover. They can be measured by immunoassay. Several molecular markers of bone, cartilage and synovium have been described such as crosslinking telopeptide of collagen type II (CTX II), Glc-Gal-PYD, hyaluronic acid, type I collagen.In conclusion, using a newly developed molecular marker, early OA can be properly detected before significant joint destruction has occurred.

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Recommendations for the registration of drugs used in the treatment of osteoarthritis: an update on biochemical markers

Cited by 32 publications

References 33 publications

Evaluation of the effects of a supplementary diet containing chicken comb extract on symptoms and cartilage metabolism in patients with knee osteoarthritis

Evaluation of the effects of a supplementary diet containing chicken comb extract on symptoms and cartilage metabolism in patients with knee osteoarthritis

The need for a transparent, ethical, and successful relationship between academic scientists and the pharmaceutical industry: a view of the Group for the Respect of Ethics and Excellence in Science (GREES)

Assessment of Disease Activity and Progression of Osteoarthritis With Using Molecular Markers of Cartilage and Synovium Turnover

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