Reconfigurable scaffolds for adaptive tissue regeneration

Peng, Mingxing; Zhao, Qilong; Wang, Min; Du, Xuemin

doi:10.1039/d3nr00281k

Cited by 10 publications

(5 citation statements)

References 145 publications

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“…As a result, the actin and morphology alignment of human fibroblasts were induced, suggesting that the anisotropic movement can instruct the cellular behavior in agreement to a previous study. [41] The novelty of the present study lies in the fact that the anisotropic movement of the abdomen was synchronized with BMR mesh under implantation, thereby suggesting a considerable solution to prevent hernia recurrence. This novelty was gen-erated by analyzing the influence of mesh patterns to support the movement and regeneration of abdominal tissue.…”

Section: Discussionmentioning

confidence: 95%

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Shape‐Configurable Mesh for Hernia Repair by Synchronizing Anisotropic Body Motion

Lee

Lee³

et al. 2023

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Continuous progress has been made in elucidating the relationship between material property, device design, and body function to develop surgical meshes. However, an unmet need still exists wherein the surgical mesh can handle the body motion and thereby promote the repair process. Here, the hernia mesh design and the advanced polymer properties are tailored to synchronize with the anisotropic abdominal motion through shape configuration. The thermomechanical property of shape configurable polymer enables molding of mesh shape to fit onto the abdominal structure upon temperature shift, followed by shape fixing with the release of the heat energy. The microstructural design of mesh is produced through finite element modeling to handle the abdominal motion efficiently through the anisotropic longitudinal and transverse directions. The design effects are validated through in vitro, ex vivo, and in vivo mechanical analyses using a self‐configurable, body motion responsive (BMR) mesh. The regenerative function of BMR mesh leads to effective repair in a rat hernioplasty model by effectively handling the anisotropic abdomen motion. Subsequently, the device‐tissue integration is promoted by promoting healthy collagen synthesis with fibroblast‐to‐myofibroblast differentiation. This study suggests a potential solution to promote hernia repair by fine‐tuning the relationship between material property and mesh design.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Shape‐Configurable Mesh for Hernia Repair by Synchronizing Anisotropic Body Motion

Lee

Lee³

et al. 2023

Small

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“…Recently, our group found that surface topographical cues could modulate cell affinity on demand. [119] Accordingly, a microelectrode array with micro-cone surface topographies has been designed and developed, [116] which could simultaneously enhance the formation of neural networks and inhibit the adhesion of astrocytes (Figure 13d), holding promises to address the cell affinity challenges of the implants for visual restoration.…”

Section: Interfacial Adaptionmentioning

confidence: 99%

Adaptive Interfacial Materials and Implants for Visual Restoration

Zhu,

Wang,

Zhao

et al. 2024

Adv Funct Materials

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Blindness is a globally critical challenge for public health, affecting more than 43 million individuals worldwide. Retinal degenerative diseases including retinitis pigmentosa and age‐related macular degeneration, involving degeneration of retinal pigment epithelium (RPE) and thereby the dysfunction of retina, are primary causes of blindness. For treating these retinal degeneration diseases, emerging interfacial materials and implants that can adapt to nerve tissues and stimulate residual neurons within the visual pathway have shown particular promise, where some issued products are approved for commercialization. Given the attractive opportunities and challenges of the interfacial materials and implants for visual restoration, a comprehensive and state‐of‐the‐art review that provides insight into their design principle and biological performances will be urgently required yet missing. In this review, the latest progress of these adaptive interfacial materials and implants for visual restoration will be summarized, and their challenges and opportunities for clinical use will be further discussed.

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“…[11] These distinctive features have positioned PEDOTs as an attractive candidate for the fabrication of biodegradable and electroconductive polymers, particularly in the field of tissue engineering (TE) scaffolds. [12][13][14][15][16][17] In general, TE scaffolds are designed to be nanoporous, electroconductive, and biodegradable structures that can provide temporary support for tissue. [18][19][20][21] However, a critical challenge lies in the fact that PEDOTs, along with many other CPs, exhibit low or non-biodegradability, brittleness, and insolubility.…”

Section: Introductionmentioning

confidence: 99%

Combining Step‐Growth and Chain‐Growth Polymerizations in One Pot: Light‐Induced Fabrication of Conductive Nanoporous PEDOT‐PCL Scaffold

Tabak,

Kaya,

Isci

et al. 2023

Macromol. Rapid Commun.

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A novel method based on light‐induced fabrication of a poly (3,4‐ethylenedioxythiophene)‐polycaprolactone (PEDOT‐PCL) scaffold using phenacyl bromide (PAB) as a single‐component photoinitiator is presented. HBr released from the step‐growth polymerization of EDOT is utilized as an in situ catalyst for the chain‐growth polymerization of ε‐caprolactone. Detailed investigations disclose the formation of a self‐assembled nanoporous electroconductive scaffold (1.2 mS cm−1). Fluorescence emission spectra of the fabricated scaffold exhibit a mixed solvatochromic behavior, indicating specific interactions between the self‐assembled scaffold and solvents with varying polarities, as evidenced by transmission electron microscopy (TEM). Moreover, the same light‐induced technique can also be applied for bulk photopolymerization showcasing the versatility and wide‐ranging scope of the originated method. In brief, this study introduces a novel approach for light‐induced polymerization reactions that is merging step‐growth and chain‐growth mechanisms. This innovative approach is promising to facilitate in situ polymerization of monomers possessing diverse functionalities.

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Reconfigurable scaffolds for adaptive tissue regeneration

Abstract: Tissue engineering and regenerative medicine have offered promising alternatives for clinical treatments of body tissue traumas, losses, dysfunctions, or diseases, where scaffold-based strategies are particularly popular and effective. Over the...

Cited by 10 publications

References 145 publications

Shape‐Configurable Mesh for Hernia Repair by Synchronizing Anisotropic Body Motion

Shape‐Configurable Mesh for Hernia Repair by Synchronizing Anisotropic Body Motion

Adaptive Interfacial Materials and Implants for Visual Restoration

Combining Step‐Growth and Chain‐Growth Polymerizations in One Pot: Light‐Induced Fabrication of Conductive Nanoporous PEDOT‐PCL Scaffold

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