Reconstituted influenza virus envelopes as an efficient carrier system for cellular delivery of small-interfering RNAs

Jonge, Jørgen de; Holtrop, Marijke; Wilschut, Jan; Huckriede, Anke

doi:10.1038/sj.gt.3302673

Cited by 66 publications

(47 citation statements)

References 72 publications

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“…One of the earliest and still major strategies used for delivery involves virus-based vectors, including retroviruses, adenoviruses, and adeno-associated viruses, which have been modified to carry engineered payloads and cell-targeting elements (79,80). Self-assembled virus-like particles (VLPs) and virosomes (virion-like phospholipid bilayer vesicles with surface glycoproteins) can also carry biomolecular cargo (81,82). Such delivery modes are quite promising, and some have been approved for use in humans.…”

Section: In Vivo Diagnosticsmentioning

confidence: 99%

Synthetic biology devices for in vitro and in vivo diagnostics

Slomovic

Pardee

Collins

2015

Proc. Natl. Acad. Sci. U.S.A.

301

228

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There is a growing need to enhance our capabilities in medical and environmental diagnostics. Synthetic biologists have begun to focus their biomolecular engineering approaches toward this goal, offering promising results that could lead to the development of new classes of inexpensive, rapidly deployable diagnostics. Many conventional diagnostics rely on antibody-based platforms that, although exquisitely sensitive, are slow and costly to generate and cannot readily confront rapidly emerging pathogens or be applied to orphan diseases. Synthetic biology, with its rational and short design-to-production cycles, has the potential to overcome many of these limitations. Synthetic biology devices, such as engineered gene circuits, bring new capabilities to molecular diagnostics, expanding the molecular detection palette, creating dynamic sensors, and untethering reactions from laboratory equipment. The field is also beginning to move toward in vivo diagnostics, which could provide near real-time surveillance of multiple pathological conditions. Here, we describe current efforts in synthetic biology, focusing on the translation of promising technologies into pragmatic diagnostic tools and platforms.synthetic biology | diagnostics | biosensing | synthetic gene networks | nanobiotechnology

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Section: In Vivo Diagnosticsmentioning

confidence: 99%

Synthetic biology devices for in vitro and in vivo diagnostics

Slomovic

Pardee

Collins

2015

Proc. Natl. Acad. Sci. U.S.A.

301

228

View full text Add to dashboard Cite

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“…328 Virosomes reconstituted from viral lipids and proteins have been also used to encapsulate small interfering RNA ( siRNA). 329 They have also gained attention as potential drug and gene delivery carriers, owing to their ease of production and modification as well as their low toxicity. 330 Their in vivo applications for drug delivery, however, are limited by the potential risk of immunogenicity.…”

Section: Nanomedicines Based On Hybrid Biomimetic Systemsmentioning

confidence: 99%

Biomimetic Systems in Nanomedicine

Carmona-Ribeiro¹

2014

Frontiers in Nanobiomedical Research

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Mimicking Nature has been a major source of inspiration for producing novel pharmaceutical formulations with improved therapeutic index and reduced toxicity. In Nature, the self-assembly of biomolecules driven by intermolecular interactions leads to highly functional, nanosized biological machines. Novel directions for drug and vaccine delivery to cure or prevent disease somehow have to copy Mother Nature wisdom. In this chapter, smart nanocarriers produced from the self-assembly of biocompatible polymers, lipids or hybrid nanoparticles (NPs) are presented and some of their applications in antimicrobial chemotherapy, drug and vaccine delivery discussed. Self-Assembly and Intermolecular InteractionsWeak intermolecular interactions are important for the rational design of novel biomimetic materials. Main weak interactions are the van der Waals interaction (ion-dipole, dipole-dipole, dipole-induced dipole interactions, induced-dipole induced-dipole), the electrostatic interaction, the hydrogen bonds, the hydrophobic interactions and the steric repulsion. 1,2 The weak but cooperative hydrogen bonding between the two strands of double-stranded DNA is a wise approach used by Nature to keep the strands together without hampering replication and transcription. 3 The repulsion between nonpolar Handbook of Nanobiomedical Research Downloaded from www.worldscientific.com by UNIVERSITY OF BIRMINGHAM LIBRARY -INFORMATION SERVICES on 03/21/15. For personal use only.

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“…Modified virus envelopes can be adapted to deliver nucleic acids to cells. Fusogenic influenza virus envelopes were used to deliver fluorescent dye-labeled siRNAs by IP injection in mice [186], hemagglutinating virus of Japan (HVJ) envelopes were used to deliver siRNAs via direct intratumor injection in mice [187], and SV40 pseudovirions are being tested as a delivery vehicle [188]. These delivery tools and other potential ligands such as mannose and aptamers [151] will need careful evaluation for efficacy and potential antigenicity if they are to be considered for therapeutic applications.…”

Section: Other Cell Targeting Ligandsmentioning

confidence: 99%