Reconstructing nanofibers from natural polymers using surface functionalization approaches for applications in tissue engineering, drug delivery and biosensing devices

Sofi, Hasham S.; Ashraf, Roqia; Khan, Abdul Hanan; Beigh, Mushtaq A.; Majeed, Shafquat; Sheikh, Faheem A.

doi:10.1016/j.msec.2018.10.069

Cited by 87 publications

(51 citation statements)

References 174 publications

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“…A wide range of self-assembled polymeric nanostructures have been used for drug delivery, but biodegradability is essential to overcome side effects and toxicity to healthy tissues (Sofi et al, 2018;George et al, 2019). The selfassembled nanostructures are formed from both natural and synthetic polymers.…”

Section: Polymersmentioning

confidence: 99%

“…Natural polymers possess abundance of functional groups, amenable to modifications via chemical or biochemical routes that result in the generation of different types of biopolymerbased materials (Nitta and Numata, 2013;Abedini et al, 2018;Sofi et al, 2018). Among these natural polymers, polysaccharides constitute an important class of polymers which are being used more frequently for various biomedical applications.…”

Section: Natural Polymersmentioning

confidence: 99%

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Nanoscale Self-Assembly for Therapeutic Delivery

Yadav

Sharma

Kumar

2020

Front. Bioeng. Biotechnol.

219

149

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Self-assembly is the process of association of individual units of a material into highly arranged/ordered structures/patterns. It imparts unique properties to both inorganic and organic structures, so generated, via non-covalent interactions. Currently, selfassembled nanomaterials are finding a wide variety of applications in the area of nanotechnology, imaging techniques, biosensors, biomedical sciences, etc., due to its simplicity, spontaneity, scalability, versatility, and inexpensiveness. Self-assembly of amphiphiles into nanostructures (micelles, vesicles, and hydrogels) happens due to various physical interactions. Recent advancements in the area of drug delivery have opened up newer avenues to develop novel drug delivery systems (DDSs) and selfassembled nanostructures have shown their tremendous potential to be used as facile and efficient materials for this purpose. The main objective of the projected review is to provide readers a concise and straightforward knowledge of basic concepts of supramolecular self-assembly process and how these highly functionalized and efficient nanomaterials can be useful in biomedical applications. Approaches for the self-assembly have been discussed for the fabrication of nanostructures. Advantages and limitations of these systems along with the parameters that are to be taken into consideration while designing a therapeutic delivery vehicle have also been outlined. In this review, various macro-and small-molecule-based systems have been elaborated. Besides, a section on DNA nanostructures as intelligent materials for future applications is also included.

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Section: Polymersmentioning

confidence: 99%

Section: Natural Polymersmentioning

confidence: 99%

Nanoscale Self-Assembly for Therapeutic Delivery

Yadav

Sharma

Kumar

2020

Front. Bioeng. Biotechnol.

219

149

View full text Add to dashboard Cite

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“…Surface immobilization (usually, covalent immobilization) enables the attachment of the biomolecules on the surface of the fibers by a chemical bond. Through this method, the surface features of fibrous membranes may be modified [68,84,85].…”

Section: Drug Loaded Electrospun Wound Dressingsmentioning

confidence: 99%

Bio-Based Electrospun Fibers for Wound Healing

Azimi

Maleki

Zavagna

et al. 2020

JFB

163

106

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Being designated to protect other tissues, skin is the first and largest human body organ to be injured and for this reason, it is accredited with a high capacity for self-repairing. However, in the case of profound lesions or large surface loss, the natural wound healing process may be ineffective or insufficient, leading to detrimental and painful conditions that require repair adjuvants and tissue substitutes. In addition to the conventional wound care options, biodegradable polymers, both synthetic and biologic origin, are gaining increased importance for their high biocompatibility, biodegradation, and bioactive properties, such as antimicrobial, immunomodulatory, cell proliferative, and angiogenic. To create a microenvironment suitable for the healing process, a key property is the ability of a polymer to be spun into submicrometric fibers (e.g., via electrospinning), since they mimic the fibrous extracellular matrix and can support neo- tissue growth. A number of biodegradable polymers used in the biomedical sector comply with the definition of bio-based polymers (known also as biopolymers), which are recently being used in other industrial sectors for reducing the material and energy impact on the environment, as they are derived from renewable biological resources. In this review, after a description of the fundamental concepts of wound healing, with emphasis on advanced wound dressings, the recent developments of bio-based natural and synthetic electrospun structures for efficient wound healing applications are highlighted and discussed. This review aims to improve awareness on the use of bio-based polymers in medical devices.

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“…Electrospinning has attracted considerable attention since the beginning of the 21st century as a simple and versatile method for manufacturing nanoscale structures in tissue engineering and biomedical field; for example, in neuronal and bone and tissue engineering [1][2][3][4]. Electrospinning is used to turn biodegradable polymers into fibrous products for application in tissue engineering scaffolds, wound dressings, drug delivery, and medical implants [5].…”

Section: Introductionmentioning

confidence: 99%

Molecular Interaction, Chain Conformation, and Rheological Modification during Electrospinning of Hyaluronic Acid Aqueous Solution

Chen

Liu

et al. 2020

Membranes

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Most of natural water-soluble polymers are difficult to electrospin due to their specific chain conformation in aqueous solution, which limits their applications. This study investigated the effects of polyethylene oxide (PEO) on the electrospinning of hyaluronic acid (HA) in HA/PEO aqueous solutions. The rheological properties of HA/PEO aqueous solutions showed polymer chain entanglement in HA was the essential factor affecting its electrospinnability. Wide-angle X-ray scattering and differential scanning calorimetry analyses of a PEO crystal showed different crystallization behavior of the PEO chain with different molecular weight, which indicates different interaction with HA. A schematic molecular model has been proposed to explain the effect of PEO on the chain conformation of HA along with the relationship between electrospinnability and chain entanglement. PEO with a relatively high molecular weight with limited crystal formation formed extensive chain entanglements with HA, while PEO with relatively low molecular weight weakened the interactions among HA chains. The findings of this study provide a wide perspective to better understand the electrospinning mechanisms of natural polyelectrolytes and usage in tissue engineering.

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Reconstructing nanofibers from natural polymers using surface functionalization approaches for applications in tissue engineering, drug delivery and biosensing devices

Cited by 87 publications

References 174 publications

Nanoscale Self-Assembly for Therapeutic Delivery

Nanoscale Self-Assembly for Therapeutic Delivery

Bio-Based Electrospun Fibers for Wound Healing

Molecular Interaction, Chain Conformation, and Rheological Modification during Electrospinning of Hyaluronic Acid Aqueous Solution

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