Reconstruction of Fallopian Tubes by Vein and Artery Transplants

Davids, Arthur M.; Bellwin, Alexander

doi:10.1016/s0015-0282(16)31681-8

Cited by 19 publications

(4 citation statements)

References 5 publications

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“…In studies to develop a suitable substitute for the fallopian tube, various artificial and biological grafts have been tested, mostly in animal experiments. However, none of these restored fertility (1)(2)(3)(4)(5)(6)(7). The reason for their failure might be that the substitute was not integrated in the process of natural wound repair.…”

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confidence: 99%

Segmental Uterine Horn Replacement in the Rat Using a Biodegradable Microporous Synthetic Tube

et al. 1986

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To investigate the possible use of a biodegradable microporous synthetic tube for fallopian tube replacement, polyetherurethane/poly-L-lactide (PU/PLLA) grafts in the uterine horn of the rat were studied and their patency and healing characteristics compared with those of nonbiodegradable polytetrafluoroethylene (PTFE; Teflon) grafts as well as with those of reanastomosed uterine horns. Regarding the healing characteristics, the PU/PLLA grafts were superior to the PTFE graft, as was indicated by the regeneration of endometrium and the extensive perigraft tissue ingrowth. However, the graft/uterine anastomoses of the PU/PLLA and PTFE grafts became obstructed by a plug of mucosal folds, all reanastomosed, uterine horns in the control experiments remaining open. In conclusion, although biodegradable microporous PU/PLLA uterine horn grafts have better healing characteristics than PTFE grafts, they easily obstruct at the graft/uterine junction. Mucosal suturing and/or the use of splints may contribute to the feasibility of biodegradable microporous artificial fallopian tubes in tubal surgery.

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confidence: 99%

Segmental Uterine Horn Replacement in the Rat Using a Biodegradable Microporous Synthetic Tube

et al. 1986

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“…Attempts to bypass the oviducts and place the ovary in continuity with the endometrial cavity (Estes 1910;Beylh & Polishuk 1979) or alternatively substitute the oviduct with surrogate conduits such as the ileum 0306-5456/S2/0S00-0645%02.00 0 1982 British Journal of Obstetrics and Gynaecology (Kucharczuk & Greene 1956;Carey et al 1958;Wingate et ul. 1970), vermiform appendix (O'Neill 1966), peritoneal tunnels (Grant 1971), vascular grafts (Davids & Bellwin 1954) or silastic tubing (Wood et al 1971) proved unpredictable even in experimental animals.…”

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confidence: 99%

Pregnancy after autografting and allografting vascularized ovaries and en bloc vascularized ovaries with adnexa in rabbits

Green

Simpkin

Grimaldi

et al. 1982

BJOG

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Summary. Initially, techniques for autografting ovaries with or without adnexa were developed but a 30% vascular failure rate was experienced by day 14. Of the technically successful grafts, 50% proved fertile. Single vascularized ovaries with their oviducts were then allografted into bilaterally ovariectomized rabbits by microsurgical techniques and the vascular failure rate was reduced to 5% of 40 grafts. The time‐course of rejection in untreated recipients was mapped by histological examination and by 24‐h culture of fallopian tubes after autopsy at different times after transplantation. Control allografts were consistently rejected by day 20. Striking prolongation of both types of graft was obtained with a short 17‐day course of cyclosporin A at 10 or 15 mg day−1kg−1. Indeed, significant evidence of rejection was found in only two ovaries out of 20 so far examined histologically. Mating behaviour, ovulation, ciliary function and transport of ova appeared normal in 80% of the recipients as long as 18 weeks after stopping cyclosporin A treatment. Only one of the ovarian allografted rabbits has so far been mated and this produced seven normal young 126 days after transplantation. However, none of the five animals mated after being allografted with en bloc adnexa have so far become pregnant.

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“…Despite notable improvement in the overall results of tuboplasty, a suitable method is still needed for replacement of part or all of the oviduct or uterus, when correcting extensive damage. The structural similarities of the ileum and genital duct have suggested the use of the former to various authors (Davids and Bellwin 1954, Kucharczuk and Geene 1956, Carey et al 1958, O'Neill 1966 Correspondence to: Dr. J. Ortega-Moreno, c/Cadena de la Granja n o 4, t ° izda, 50007 Zaragoza, Spain et al 1982). These attempts, however, have proved unsuccessful, except for a pregnancy in 1 of the 8 bitches subjected to ileocornual grafts (Wingate et al 1970).…”

Section: In~oducfionmentioning

confidence: 99%

Structural changes of a devascularizated colonic graft when its replaces the rat uterine horn

Ortega-Moreno

Caballero-Gómez

1992

Arch Gynecol Obstet

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A one centimeter length of the left uterine horn in two groups of Wistar rats (n = 10) was replaced with normal (VAS group) or with denervated and devascularizated (NVAS group) colonic grafts. All animals maintained pregnancy in the right control horns but not in the grafted horns. At 40, 60 and 90 days after surgery, the light microscopic appearance of the autografts was studied. In the VAS group, and with respect to the last period, the number (5.5 +/- 0.7) and height (1.0 +/- 0.1 mm, P < 0.05 ANOVA) of the folds, the intestinal glands height (160.2 +/- 21.2 mu, P < 0.05 ANOVA) and the number of globet cells per gland (26.6 +/- 4.2, P < 0.05 ANOVA) had decreased in relation to the colon control (6.0 +/- 0.7, 1.4 +/- 0.1, 251.7 +/- 31.8, 42.6 +/- 5.2 respectively). A similar intestinal structure to that described above was observed in the anastomosis areas of the NVAS group, and therefore a decreased mucus production was maintained in this areas. No folds or intestinal glands were observed, but a monoestratified cubic epithelial cells type was observed along 63.7 +/- 4.1% of the NVAS colonic graft center. Under this epithelium a connective tissue, like a non-glandular submucosa, was obtained.

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Reconstruction of Fallopian Tubes by Vein and Artery Transplants

Cited by 19 publications

References 5 publications

Segmental Uterine Horn Replacement in the Rat Using a Biodegradable Microporous Synthetic Tube

Segmental Uterine Horn Replacement in the Rat Using a Biodegradable Microporous Synthetic Tube

Pregnancy after autografting and allografting vascularized ovaries and en bloc vascularized ovaries with adnexa in rabbits

Structural changes of a devascularizated colonic graft when its replaces the rat uterine horn

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