Reconstruction of the Architecture of Ventricular Myocardial Fibers in Ex Vivo Human Hearts

Gao, Changqing; Lü, Kun; Ye, Weihua; Li, Libing; Cheng, Liuquan

doi:10.1532/hsf98.20091051

Cited by 6 publications

(3 citation statements)

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“…In our study, we found that there were damages in ascending and descending segments in heart with anterior wall infarction. According to Torrent's hypothesis, descending segment contraction is the main force for ventricle ejection and ascending segment contraction is the main force for ventricle filling during 'isovolumetric relaxation' phase of diastole [8]. Our results indicated greater damages in ascending segment than those in descending segment.…”

Section: Disscussionmentioning

confidence: 51%

“…This is) material basis of cardiac pumping function with high efficiency. Whatever causes damage in VMB will inevitably impair ejection and filling function [8]. …”

Section: Disscussionmentioning

confidence: 99%

“…Torrent's hypothesis [4-17], ventricular myocardial band (VMB) theory, more reasonably elucidates three-dimension structure of myocardial fibers and the interaction of form with function in heart. According to VMB theory, cardiac ejection and filling function will be compromised whatever causes myocardial fiber damages in ascending or descending segment of heart [8]. In our previous study, we explored three-dimension architecture of myocardial fibers and sequential contractile function of ventricular myocardial band in the healthy hearts of pigs and humans [9-12].…”

Section: Introductionmentioning

confidence: 99%

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Three-dimension structure of ventricular myocardial fibers after myocardial infarction

Gao

2010

J Cardiothorac Surg

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BackgroundTo explore the pathological changes of three-dimension structure of ventricular myocardial fibers after anterior myocardial infarction in dog heart.MethodsFourteen acute anterior myocardial infarction models were made from healthy dogs (mean weight 17.6 ± 2.5 kg). Six out of 14 dogs with old myocardial infarction were sacrificed, and their hearts were harvested after they survived the acute anterior myocardial infarction for 3 months. Each heart was dissected into ventricular myocardial band (VMB), morphological characters in infarction region were observed, and infarct size percents in descending segment and ascending segment were calculated.ResultsSix dog hearts were successfully dissected into VMB. Uncorresponding damages in myocardial fibers of descending segment and ascending segment were found in apical circle in anterior wall infarction. Infarct size percent in the ascending segment was significantly larger than that in the descending segment (23.36 ± 3.15 (SD) vs 30.69 ± 2.40%, P = 0.0033); the long axis of infarction area was perpendicular to the orientation of myocardial fibers in ascending segment; however, the long axis of the infarction area was parallel with the orientation of myocardial fibers in descending segment.ConclusionsWe found that damages were different in both morphology and size in ascending segment and descending segment in heart with myocardial infarction. This may provide an important insight for us to understand the mechanism of heart failure following coronary artery diseases.

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Section: Disscussionmentioning

confidence: 51%

“…This is) material basis of cardiac pumping function with high efficiency. Whatever causes damage in VMB will inevitably impair ejection and filling function [8]. …”

Section: Disscussionmentioning

confidence: 99%