A review of the Amur and Primorye, Sakhalin, and the Kuril-Okhotsk region seismicity for 20182019 is presented on the basis of data from the regional network of stationary seismic stations of the Sakhalin branch of the Geophysical Survey RAS with the involvement of data from adjacent seismological Russian and foreign agencies, as well as ten stations of the local network operating in the south Sakhalin. Parameters of 4989 seismic events have been determined, 193 of them are explosions. Focal mechanisms were calculated for 88 earthquakes. 116 earthquakes have shown a macroseismic effect. A map of the epicenters is presented, the distribution of the number N of crustal and deep-focus earthquakes by a magnitude, a total seismic energy ∑E for seismically active regions of three regions are given, in comparison with the average parameters N and ∑E for 20012017. For each region, an analysis of the parameters of the seismic regime in 20182019 is given in comparison with long-term averages, the maximum and significant seismic events are described. The seismicity of the Priamurye and Primorye, Sakhalin, and the Kuril-Okhotsk region in 20182019 can be characterized as a moderate one.