Reconstruction using a divided latissimus dorsi muscle flap after conventional posterolateral thoracotomy and the effectiveness of indocyanine green-fluorescence angiography to assess intraoperative blood flow

Kuriyama, Masafumi; Yano, Akiko; Yoshida, Yukitaka; Kubo, Maiko; Akita, Shinsuke; Mitsukawa, Nobuyuki; Satoh, Kaneshige; Yamamoto, Shin; Sasaguri, Shiro; Orihashi, Kazumasa

doi:10.1007/s00595-015-1181-8

Cited by 14 publications

(13 citation statements)

References 30 publications

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“…Forty-nine articles, including 1996 surgical flaps, were selected for the review. Study designs included prospective cohort studies (n = 27), 31,34,35,38,39,[41][42][43][47][48][49][50]56,[58][59][60][62][63][64][65][66][67][68][69][70][71] retrospective cohort studies (n = 16), [25][26][27]29,32,33,36,40,44,45,51,55,57,61,72 prospective pilot studies (n = 3), 28,37,52 and retrospective case series (n = 3). 46,53,54 No randomized controlled trials have been performed yet that concern ICGA in plastic and reconstructive flap surgery.…”

Section: Systematic Reviewmentioning

confidence: 99%

Optimizing Indocyanine Green Fluorescence Angiography in Reconstructive Flap Surgery: A Systematic Review and Ex Vivo Experiments

et al. 2019

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Background. Indocyanine green angiography (ICGA) offers the potential to provide objective data for evaluating tissue perfusion of flaps and reduce the incidence of postoperative necrosis. Consensus on ICGA protocols and information on factors that have an influence on fluorescence intensity is lacking. The aim of this article is to provide a comprehensive insight of in vivo and ex vivo evaluation of factors influencing the fluorescence intensity when using ICGA during reconstructive flap surgery. Methods. A systematic literature search was conducted to provide a comprehensive overview of currently used ICGA protocols in reconstructive flap surgery. Additionally, ex vivo experiments were performed to further investigate the practical influence of potentially relevant factors. Results. Factors that are considered important in ICGA protocols, as well as factors that might influence fluorescence intensity are scarcely reported. The ex vivo experiments demonstrated that fluorescence intensity was significantly related to dose, working distance, angle, penetration depth, and ambient light. Conclusions. This study identified factors that significantly influence the fluorescence intensity of ICGA. Applying a weight-adjusted ICG dose seems preferable over a fixed dose, recommended working distances are advocated, and the imaging head during ICGA should be positioned in an angle of 60° to 90° without significantly influencing the fluorescence intensity. All of these factors should be considered and reported when using ICGA for tissue perfusion assessment during reconstructive flap surgery.

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Section: Systematic Reviewmentioning

confidence: 99%

Optimizing Indocyanine Green Fluorescence Angiography in Reconstructive Flap Surgery: A Systematic Review and Ex Vivo Experiments

et al. 2019

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“…Indocyanine green (ICG) is an FDA-approved water-soluble anionic tricarbocyanine dye. As ICG has low toxicity, it is used for various medical examinations, such as the measurement of cardiac output and hepatic function, ophthalmic angiography, and the detection of sentinel lymph nodes (13)(14)(15)(16). In addition, ICG has the properties to act as a near-infrared ray (NIR) photosensitizer for PDT, generating heat and ROS by NIR irradiation (17).…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Therapy Using Indocyanine Green Loaded on Super Carbonate Apatite as Minimally Invasive Cancer Treatment

Tamai

Mizushima

et al. 2018

Molecular Cancer Therapeutics

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Minimally invasive treatment is getting more and more important in an aging society. The purpose of this study was to explore the possibility of ICG loaded on super carbonate apatite (sCA) nanoparticles as a novel photodynamic therapy (PDT) against cancers. Using colon cancer cells, ICG uptake and anti-tumor effects were examined between the treatments of ICG and sCA-ICG. Reactive oxygen species (ROS) production and temperature rise were also evaluated to explore the underlying mechanism. Atomic force microscopy revealed that the size of sCA-ICG ranged from 10 to 20 nm. In aqueous solution with 0.5% albumin, the temperature increase after laser irradiation was 27.1°C and 23.1°C in sCA-ICG and ICG, respectively (control DW: 5.7°C). A significant increase in ROS generation was noted in cell cultures treated with sCA-ICG plus irradiation compared with those treated with ICG plus irradiation ( < 0.01). Uptake of ICG in the tumor cells significantly increased in sCA-ICG compared with ICG and The fluorescence signals of ICG in the tumor, liver, and kidney faded away in both treatments by 24 hours. Finally, the HT29 tumors treated with sCA-ICG followed by irradiation exhibited drastic tumor growth retardation ( < 0.01), whereas irradiation of tumors after injection of ICG did not inhibit tumor growth. This study shows that sCA is a useful vehicle for ICG-based PDT. Quick withdrawal of ICG from normal organs is unique to sCA-ICG and contrasts with the other nanoparticles remaining in normal organs for a long time. .

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“…In the described experiments, hand-held imaging systems and microscopes with an integrated NIRF were equally divided for imaging. There were four different hand-held systems (PDE n = 13, Visionsense n = 1, Fluobeam n = 2, and HyperEye n = 1) [ 7 – 19 , 44 – 46 , 49 ], one non-hand-held system (FLARE n = 8) [ 36 – 43 ], and three types of microscopes with an integrated NIRF (SPY n = 16, LEICA n = 2, and Pentero n = 1) [ 20 – 35 , 47 , 48 ] suitable for fluorescence image guidance. In one study, a prototype was used which was not further specified [ 51 ]; three articles unfortunately did not state what kind of imaging system was used [ 52 – 54 ].…”

Section: Resultsmentioning

confidence: 99%

Near-infrared fluorescence image-guidance in plastic surgery: A systematic review

et al. 2018

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BackgroundNear-infrared fluorescence (NIRF) imaging technique, after administration of contrast agents with fluorescent characteristics in the near-infrared (700–900 nm) range, is considered to possess great potential for the future of plastic surgery, given its capacity for perioperative, real-time anatomical guidance and identification. This study aimed to provide a comprehensive literature review concerning current and potential future applications of NIRF imaging in plastic surgery, thereby guiding future research.MethodsA systematic literature search was performed in databases of Cochrane Library CENTRAL, MEDLINE, and EMBASE (last search Oct 2017) regarding NIRF imaging in plastic surgery. Identified articles were screened and checked for eligibility by two authors independently.ResultsForty-eight selected studies included 1166 animal/human subjects in total. NIRF imaging was described for a variety of (pre)clinical applications in plastic surgery. Thirty-two articles used NIRF angiography, i.e., vascular imaging after intravenous dye administration. Ten articles reported on NIRF lymphography after subcutaneous dye administration. Although currently most applied, general protocols for dosage and timing of dye administration for NIRF angiography and lymphography are still lacking. Three articles applied NIRF to detect nerve injury, and another three studies described other novel applications in plastic surgery.ConclusionsFuture standard implementation of novel intraoperative optical techniques, such as NIRF imaging, could significantly contribute to perioperative anatomy guidance and facilitate critical decision-making in plastic surgical procedures. Further investigation (i.e., large multicenter randomized controlled trials) is mandatory to establish the true value of this innovative surgical imaging technique in standard clinical practice and to aid in forming consensus on protocols for general use.Level of Evidence: Not ratable

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Reconstruction using a divided latissimus dorsi muscle flap after conventional posterolateral thoracotomy and the effectiveness of indocyanine green-fluorescence angiography to assess intraoperative blood flow

Abstract: Intraoperative ICG-FA proved extremely useful for assessing altered blood flow of the divided LD and for selecting preserved intercostal perforators.

Cited by 14 publications

References 30 publications

Optimizing Indocyanine Green Fluorescence Angiography in Reconstructive Flap Surgery: A Systematic Review and Ex Vivo Experiments

Optimizing Indocyanine Green Fluorescence Angiography in Reconstructive Flap Surgery: A Systematic Review and Ex Vivo Experiments

Photodynamic Therapy Using Indocyanine Green Loaded on Super Carbonate Apatite as Minimally Invasive Cancer Treatment

Near-infrared fluorescence image-guidance in plastic surgery: A systematic review

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