Reconstructive Plastic Surgical Nursing

Storch, Jill E.; Rice, Jan

doi:10.1002/9780470774656

Cited by 3 publications

(1 citation statement)

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“…Myofibroblasts are the principal cell type responsible for scar contraction (Li and Wang, 2011), and are derived from fibroblasts ∼2 weeks postwounding (Singer and Clark, 1999). PDGF and TGF-β stimulate this cellular differentiation and the resultant contractile force exerted by the myofibroblasts enables wound edges in humans to come together, at a rate of ∼0.75 mm a day (Figure 1) (Werner and Grose, 2003;Storch and Rice, 2005). Of course, in normal scars this wound contraction is an essential process; however, myofibroblasts typically go through apoptosis postepithelialization, thus halting contractive pathways (Desmoulière et al, 2005).…”

Section: Scar Formationmentioning

confidence: 99%

Electrospun Biomaterials in the Treatment and Prevention of Scars in Skin Wound Healing

Mulholland

2020

Front. Bioeng. Biotechnol.

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Electrospinning is a promising method for the rapid and cost-effective production of nanofibers from a wide variety of polymers given the high surface area morphology of these nanofibers, they make excellent wound dressings, and so have significant potential in the prevention and treatment of scars. Wound healing and the resulting scar formation are exceptionally well-characterized on a molecular and cellular level. Despite this, novel effective anti-scarring treatments which exploit this knowledge are still clinically absent. As the process of electrospinning can produce fibers from a variety of polymers, the treatment avenues for scars are vast, with therapeutic potential in choice of polymers, drug incorporation, and cell-seeded scaffolds. It is essential to show the new advances in this field; thus, this review will investigate the molecular processes of wound healing and scar tissue formation, the process of electrospinning, and examine how electrospun biomaterials can be utilized and adapted to wound repair in the hope of reducing scar tissue formation and conferring an enhanced tensile strength of the skin. Future directions of the research will explore potential novel electrospun treatments, such as gene therapies, as targets for enhanced tissue repair applications. With this class of biomaterial gaining such momentum and having such promise, it is necessary to refine our understanding of its process to be able to combine this technology with cutting-edge therapies to relieve the burden scars place on world healthcare systems.

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Section: Scar Formationmentioning

confidence: 99%

Electrospun Biomaterials in the Treatment and Prevention of Scars in Skin Wound Healing

Mulholland

2020

Front. Bioeng. Biotechnol.

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Wound Dressings Update

Weller

Sussman

2006

Pharmacy Practice and Res

114

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The availability of different types of wound dressings has increased in the last decade. Wound care practitioners have at their disposal an extensive range of dressings. Emerging dressing types include interactive/bioactive dressings and tissue-engineered skin substitutes. There is no one dressing that is suitable for the management of all types of chronic wounds and few are suited for the treatment of a single wound during all stages of the healing cycle. Successful wound management depends on an understanding of the healing process combined with knowledge of the properties of the various dressings available. Without such knowledge and careful assessment of all the factors that effect healing, dressing selection is likely to be arbitrary and ineffective, wasteful both in terms of time and physical resources. This article is an overview of some of the first-line and second-line interactive/bioactive dressings available. A synopsis of wound assessment and wound bed preparation will aid in choosing the appropriate dressings. It will also touch on advanced technologies including tissue-engineered skin substitutes. INTRODUCTIONNormal wound healing processes require restoration of epithelialisation and collagen formation. The first occurs by migration and proliferation of keratinocytes from the wound edges and by differentiation of stem cells from remaining hair follicle bulbs. The second occurs by influx of growth factors secreted by macrophages, platelets and fibroblasts, by fibroblast proliferation and subsequent synthesis and remodelling of collagenous dermal matrix. However, in the case of full-thickness burn injuries and chronic wounds such as pressure ulcers, venous ulcers and diabetic foot ulcers these processes are damaged and new technologies have been developed to improve the healing in these conditions. 1 The time it takes for a chronic wound to heal varies due to the idiosyncratic nature of each wound and inherent complex factors, which may impede healing. Infection, poor blood supply, immobility, diabetes, medicines, inadequate hydration and nutrition, trauma and poor wound management are causative or contributory factors. Tissue repair research and advances in moist wound healing pharmaceuticals have been pivotal in improving wound dressing technology. 2 Clinical experience suggests that wound healing is often impaired in the elderly. The elderly have a high prevalence of chronic leg and pressure ulcers and are vulnerable to skin tears that can be slow to heal due to decreased dermal thickness and the loss of proliferative capacity of the ageing dermis. 3 Chronic wounds represent a significant burden in human and economic costs. 4

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Factors Influencing the Occurrence of Hypertrophic Scars Among Postoperative Patients in Garut, Indonesia

Nugraha¹,

Chaidir

Rahayu

et al. 2017

Belitung Nurs J

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Background: Hypertrophic scar causes physical and psychological problems. Thus understanding the factors related to the occurrence of hypertrophic scar tissue is needed. Little is known about its influencing factors in Indonesia, especially in Garut.Objective: This study aims to examine the relationships between hypertrophic scar and its influencing factors, and identify the most dominant factor of the occurrence of hypertrophic scars.Methods: This was an observational case control study using retrospective approach in Polyclinic of Surgery of Regional Public Hospital of dr. Slamet of Garut Regency. There were 40 samples recruited in this study by purposive sampling, which was divided to be case group (20 patients) and control group (20 patients). Data were collected using Stony Brook Scar Evaluation Scale by observation and documentation of the medical records of patients. Data were analyzed using logistic regression analysisResults: Findings indicated that there were significant relationships between the surgical wound infection (p = 0.02), family history (p = 0.026), and type of suture (p = 0.043) with the occurrence of hypertrophic scars. The most dominant factor on the occurrence of hypertrophic scars was type of suture, acid polyglactin 910. The variables that had no significant relationships with the occurrence of hypertrophic scar tissue were age (p = 0.34), area of surgical wound (p = 0.177), and smoking habit (p = 0.479).Conclusion: There were significant relationships between infection of surgical wound, genetic history, the type of suture, and the occurrence of hypertrophic scar tissue. The most dominant factor that influenced the occurrence of hypertrophic scar tissue was the type of suture. Therefore, it is suggested to health professionals to modify the using of acid polyglactin 910 sutures, and nurses particularly need to provide the information regarding the family history and genetic-related hypertrophic scar, and prevent the infection of surgical wound after operation.

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Reconstructive Plastic Surgical Nursing

Cited by 3 publications

References 1 publication

Electrospun Biomaterials in the Treatment and Prevention of Scars in Skin Wound Healing

Electrospun Biomaterials in the Treatment and Prevention of Scars in Skin Wound Healing

Wound Dressings Update

Factors Influencing the Occurrence of Hypertrophic Scars Among Postoperative Patients in Garut, Indonesia

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