Recording locations in multichannel magnetocardiography and body surface potential mapping sensitive for regional exercise-induced myocardial ischemia

Hänninen, Helena; Takala, Panu; Mäkijärvi, Markku; Montonen, Juha; Korhonen, Petri; Oikarinen, Lasse; Simelius, Kim; Nenonen, Jukka; Katila, T.; Toivonen, Lauri

doi:10.1007/s003950170049

Cited by 50 publications

(43 citation statements)

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“…Increased repolarization heterogeneity of the diseased heart can be either anatomic, due to infarction, fibrosis, or structural remodeling; or electrophysiological, due to electrical remodeling, drugs, genetic defects, or heterogeneous autonomic innervations. 36 Chronic myocardial disease could result in both electrophysiological and structural remodeling of the heart, and both could affect the repolarization heterogeneity of ventricular myocardium. Many MCG studies investigated repolarization abnormalieffective than the time-dependent area ratio of T-wave propagation for detecting CAD (P=0.036), the early occurrence of +T waves can be used to localize the shorter action potential of ischemic myocardium.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of Magnetocardiography to Detect Coronary Artery Disease and Cardiac Allograft Vasculopathy

Lee

Liu

et al. 2013

Circ J

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Background: Electrophysiological information as well as anatomic information are important for the detection of coronary artery lesions. The aim of this study was to assess the efficacy of resting magnetocardiography (MCG) in stable coronary artery disease (CAD) and cardiac allograft vasculopathy (CAV). Methods and Results:MCG and coronary angiography were performed within 1 month in 75 patients with suspected CAD and in 26 subjects after orthotopic heart transplantation (OHT). Plaque volumes were additionally measured on intravascular ultrasound in OHT recipients. The spatially distributed QTc interval maps were constructed with 64-channel MCG. A T-wave propagation map and QTc heterogeneity index including QTc dispersion and smoothness index of QTc (SI-QTc) were derived for ischemia detection and localization. CAD patients had higher QTc dispersion and SI-QTc. Receiver operating characteristic curve analysis identified SI-QTc ≥9 ms, QTc dispersion ≥79 ms as the optimal cut-off for detecting CAD (diagnostic accuracy, 0.7953, 0.7819), better than T-wave propagation (0.6594, P<0.05). There was no significant difference of QTc dispersion between CAD and OHT subjects. In OHT recipients, QTc dispersion positively correlated with plaque volume, and SI-QTc progressively increased after transplantation. Using T-wave propagation mapping, regionally increased dispersion could be demonstrated in CAD patients, but increased dispersion was noted in fewer OHT recipients. Conclusions:MCG is clinically feasible as a non-invasive tool for diagnosis of CAD, and could be used as a surrogate marker of CAV. (Circ J 2013; 77: 1783 -1790

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Section: Discussionmentioning

confidence: 99%

Usefulness of Magnetocardiography to Detect Coronary Artery Disease and Cardiac Allograft Vasculopathy

Lee

Liu

et al. 2013

Circ J

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“…A multichannel MCG system is now available, and both Hailer et al 14 and Van Leeuwen at al 15 report that spatial dispersion of the magnetocardiographically determined QT interval is more accurate for diagnosing IHD than the QT dispersion derived from ECG. Hanninen et al 16,17 found that when using an isomagnetic MCG map the change in the orientation of the magnetic field gradient during the ST-segment or at the T-wave after exercise is greater in patients with IHD than in normal individuals. Takala et al 18 also reported that heart rate-adjusted, magnetic field map rotation during the ST-segment and T-wave could detect transient ischemia.…”

Section: Discussionmentioning

confidence: 99%

Integral Value of JT Interval in Magnetocardiography is Sensitive to Coronary Stenosis and Improves Soon After Coronary Revascularization

Watanabe

Yamada

et al. 2007

Circ J

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Background Magnetocardiography (MCG) is sensitive to minute cardiac electric abnormalities, but its clinical utility in diagnosing ischemic heart disease (IHD) has not been established. The present study examined the usefulness of an integral MCG value of ventricular repolarization in patients with IHD. Methods and Results MCG was performed at rest in 14 patients with coronary stenosis >75% confirmed by coronary angiography (IHD group) using a 64-channel system, and then the sum of the 64-channel integral values of the QRS or JT intervals (QRSi and JTi, respectively) was calculated. The JTi/QRSi value indicated the total power of currents in JT compared with those in QRS. These measurements were repeated within 2 weeks after coronary revascularization. The Control group comprised 30 healthy volunteers. The baseline value of JTi/QRSi was significantly smaller in the IHD than in the Control group, but after revascularization it increased and did not significantly differ from the Control group. No significant difference in ST deviation was identified by electrocardiography (ECG) before and after coronary revascularization. Analysis of the Control group revealed that JTi/QRSi was not affected by age. Conclusions The JTi/QRSi of the MCG is more sensitive to coronary stenosis than ECG, and this parameter improves soon after coronary revascularization. (Circ J 2007; 71: 1586 -1592

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“…Several studies have demonstrated that the orientation of the magnetic field maps (MFM) during the QT interval or the ST-T segment is a good CAD predictor, and various methods have been developed to quantify MFM orientation, and used to characterize CAD patients in different conditions [4,[8][9][10][11][12][13]. The orientation of the MFM during the QT interval and selected sub-intervals was also determined using different methods, which led to a discrimination of CAD patients that ranged from 76% to 86% [14].…”

Section: Introductionmentioning

confidence: 99%

Early detection of coronary artery disease in patients studied with magnetocardiography: An automatic classification system based on signal entropy

Steinisch

Torke

Haueisen

et al. 2013

Computers in Biology and Medicine

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Recording locations in multichannel magnetocardiography and body surface potential mapping sensitive for regional exercise-induced myocardial ischemia

Cited by 50 publications

References 0 publications

Usefulness of Magnetocardiography to Detect Coronary Artery Disease and Cardiac Allograft Vasculopathy

Usefulness of Magnetocardiography to Detect Coronary Artery Disease and Cardiac Allograft Vasculopathy

Integral Value of JT Interval in Magnetocardiography is Sensitive to Coronary Stenosis and Improves Soon After Coronary Revascularization

Early detection of coronary artery disease in patients studied with magnetocardiography: An automatic classification system based on signal entropy

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