Recovering the fetal signal in transabdominal fetal pulse oximetry

Fong, Daniel D.; Knoesen, A.; Motamedi, Mohammad; O'Neill, Terry; Ghiasi, Soheil

doi:10.1016/j.smhl.2018.07.011

Cited by 22 publications

(11 citation statements)

References 33 publications

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“…Fong et al [34] developed a continuous wave system that used two LEDs as light sources (700 and 850 nm) and detectors placed 4 and 7 cm away from the sources. The closer detector was used to pick up the mother's signal and the farther detector was used to detect the fetal signal.…”

Section: Phantom Studiesmentioning

confidence: 99%

Review of optical methods for fetal monitoring in utero

Gunther

Jayet

Sekar

et al. 2022

Journal of Biophotonics

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The current technology for monitoring fetal wellbeing during child birth is cardiotocography. However, CTG has high false positive rates that lead to unnecessary emergency Cesarean deliveries and false negatives that result in birth injuries. To curtail these issues, fetal pulse oximetery has been a topic of interest for many decades. Fetal pulse oximetry would yield the oxygen saturation of the fetus in utero and provide a more robust marker for clinicians to make decisions about performing emergency Cesarean deliveries. Here, we present a review of biomedical optical developments related to transabdominal fetal pulse oximetery in the biophotonics field and the challenges that must be overcome to make transabdominal pulse oximetry a clinical reality.

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Section: Phantom Studiesmentioning

confidence: 99%

Review of optical methods for fetal monitoring in utero

Gunther

Jayet

Sekar

et al. 2022

Journal of Biophotonics

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show abstract

“…The extracted fetal signal, captured at two wavelengths, is then used with Equation (4) to estimate fetal SpO 2 as in conventional pulse oximetry calculations. Studies have shown that ANC is superior at extracting the fetal signal [10,33]. However, its performance in relation to the differences in fetal depth remains unexplored and is investigated in this paper.…”

Section: Fetal Signal Extractionmentioning

confidence: 99%

“…Several studies have used Monte Carlo simulations to model photon transport in non-invasive fetal oximetry to investigate the maternal-fetal signal contribution [5,9,11,29,36], which showed the large influence tissue geometries have on the fetal signal sensitivity. Some were complemented with measurements across optical phantoms (which mimic the optical properties of tissue) [10,29] and showed the validity of the simulation results using representative physical models. Others have emulated the mixed-signal measurements through a variety of means to investigate various techniques to extract the fetal signal [10,28,33].…”

Section: Related Workmentioning

confidence: 99%

“…Some were complemented with measurements across optical phantoms (which mimic the optical properties of tissue) [10,29] and showed the validity of the simulation results using representative physical models. Others have emulated the mixed-signal measurements through a variety of means to investigate various techniques to extract the fetal signal [10,28,33]. Furthermore, some have tried to estimate fetal oxygenation using other spectroscopic techniques, namely near-infrared spectroscopy, by characterizing the expected path-length photons take for specific tissue models [22].…”

Section: Related Workmentioning

confidence: 99%

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Optode Design Space Exploration for Clinically-robust Non-invasive Fetal Oximetry

Fong

Srinivasan

Vali

et al. 2019

ACM Trans. Embed. Comput. Syst.

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Non-invasive transabdominal fetal oximetry (TFO) has the potential to improve delivery outcomes by providing physicians with an objective metric of fetal well-being during labor. Fundamentally, the technology is based on sending light through the maternal abdomen to investigate deep fetal tissue, followed by detection and processing of the light that returns (via scattering) to the outside of the maternal abdomen. The placement of the photodetector in relation to the light source critically impacts TFO system performance, including its operational robustness in the face of fetal depth variation. However, anatomical differences between pregnant women cause the fetal depths to vary drastically, which further complicates the optical probe (optode) design optimization. In this paper, we present a methodology to solve this problem. We frame optode design space exploration as a multi-objective optimization problem, where hardware complexity (cost) and performance across a wider patient population (robustness) form competing objectives. We propose a model-based approach to characterize the Pareto-optimal points in the optode design space, through which a specific design is selected. Experimental evaluation via simulation and in vivo measurement on pregnant sheep support the efficacy of our approach.

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“…Previous research has demonstrated the usefulness of oxygen and pH sensors to monitor acid-base status continuously in different tissues. Oxygen sensors based on either pulse-oximetry or fiber-optic sensing inserted in fetal tissue during labor in humans or placed endovascularly during endoscopic fetal surgery in sheep have shown promising results in detecting oxygen variations [5][6][7][8]. Similarly, sensors able to monitor the levels of fetal pH have also been described [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Miniaturized Electrochemical Sensors to Monitor Fetal Hypoxia and Acidosis in a Pregnant Sheep Model

et al. 2021

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Perinatal asphyxia is a major cause of severe brain damage and death. For its prenatal identification, Doppler ultrasound has been used as a surrogate marker of fetal hypoxia. However, Doppler evaluation cannot be performed continuously. We have evaluated the performance of a miniaturized multiparametric sensor aiming to evaluate tissular oxygen and pH changes continuously in an umbilical cord occlusion (UCO) sheep model. The electrochemical sensors were inserted in fetal hindlimb skeletal muscle and electrochemical signals were recorded. Fetal hemodynamic changes and metabolic status were also monitored during the experiment. Additionally, histological assessment of the tissue surrounding the sensors was performed. Both electrochemical sensors detected the pO2 and pH changes induced by the UCO and these changes were correlated with hemodynamic parameters as well as with pH and oxygen content in the blood. Finally, histological assessment revealed no signs of alteration on the same day of insertion. This study provides the first evidence showing the application of miniaturized multiparametric electrochemical sensors detecting changes in oxygen and pH in skeletal muscular tissue in a fetal sheep model.

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Recovering the fetal signal in transabdominal fetal pulse oximetry

Cited by 22 publications

References 33 publications

Review of optical methods for fetal monitoring in utero

Review of optical methods for fetal monitoring in utero

Optode Design Space Exploration for Clinically-robust Non-invasive Fetal Oximetry

Miniaturized Electrochemical Sensors to Monitor Fetal Hypoxia and Acidosis in a Pregnant Sheep Model

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