Recovery by<i>N</i>-acetylcysteine from subchronic exposure to Imidacloprid-induced hypothalamic–pituitary–adrenal (HPA) axis tissues injury in male rats

Annabi, Alya; Dhouib, Ines Bini; Lamine, Aicha Jrad; Gharbi, N.; Fazâa, Saloua El; Lasram, Mohamed Montassar

doi:10.3109/15376516.2015.1045663

Cited by 19 publications

(6 citation statements)

References 40 publications

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“…Kasson and Hsueh found that nicotine and its agonists exert an inhibitory effect on the 17-alpha hydroxylase, therefore preventing the conversion of pregnenolone and progesterone into precursors of DHEA and androstenedione respectively, thereby inhibiting testosterone synthesis in testis cells [28]. This detrimental effect of IMI on testosterone secretion has been previously reported [5, 25, 29].…”

Section: Discussionmentioning

confidence: 78%

Colibri® insecticide induces male reproductive toxicity: alleviating effects of Lannea acida (Anacardiaceae) in rats

Tetsatsi

Nkeng-Effouet

Alumeti

et al. 2019

Basic Clin. Androl.

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Background: Imidacloprid, a neonicotinoid insecticide, has been associated to severe reproductive toxicity in mammals. Although some preventive measures have been reported, curative strategies are yet to be explored. The present study was designed to investigate the alleviating effects of Lannea acida on the reproductive toxicity of colibri®, a commercial formulation of imidacloprid, in adult male rats. Materials and methods: Seventy rats were orally administered with colibri® (22.5 mg/kg, 10 mL/kg) for 14 days and treated for other 14 or 28 days with either aqueous or methanol extracts of L. acida (170 or 340 mg/kg). Control animals were similarly treated with clomiphene citrate or vitamin E. Sexual organ weights, spermatozoa characteristics, sexual hormones, stress markers and testis histology were evaluated at the end of each treatment period. Results: Colibri® exposition induced reproductive toxicity marked by a decrease in sex organ weights, spermatozoa count, motility and viability. Colibri® also decreased testosterone, luteinizing hormone, follicle stimulating hormone concentrations and increased testicular oxidative stress. Spermatozoa morphology and testis histology were also severely altered. Similar to clomiphene citrate and vitamin E, treatment with L. acida extracts significantly (p ≤ 0.05-0.001) reversed the above-mentioned damages, especially after 28 days of treatment with aqueous (340 mg/kg) and methanol (170 mg/kg) extracts. Conclusion: Present results indicate that L. acida exerts curative effects against colibri®-induced male reproductive toxicity. These results justify the use of this plant as fertility enhancer and suggest that it could be an alternative in the management of pesticide-derived male infertility.

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Section: Discussionmentioning

confidence: 78%

Colibri® insecticide induces male reproductive toxicity: alleviating effects of Lannea acida (Anacardiaceae) in rats

Tetsatsi

Nkeng-Effouet

Alumeti

et al. 2019

Basic Clin. Androl.

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“…TBT up-regulates the cell redox balance in brain areas, such as the hypothalamus, resulting in an increase in the reactive oxygen species (ROS) and cellular damage (30,114). Annabi et al (115) reported that imidacloprid insecticide, applied at 40 mg/kg for 28 days, increased malondialdehyde levels in the rat hypothalamus and pituitary. Our results agree with these previous findings by showing higher OS levels in the pituitary and adrenals in both groups of TBT rats.…”

Section: Discussionmentioning

confidence: 98%

The Environmental Pollutant Tributyltin Chloride Disrupts the Hypothalamic-Pituitary-Adrenal Axis at Different Levels in Female Rats

et al. 2016

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Tributyltin chloride (TBT) is an environmental contaminant that is used as a biocide in antifouling paints. TBT has been shown to induce endocrine-disrupting effects. However, studies evaluating the effects of TBT on the hypothalamus-pituitary-adrenal (HPA) axis are especially rare. The current study demonstrates that exposure to TBT is critically responsible for the improper function of the mammalian HPA axis as well as the development of abnormal morphophysiology in the pituitary and adrenal glands. Female rats were treated with TBT, and their HPA axis morphophysiology was assessed. High CRH and low ACTH expression and high plasma corticosterone levels were detected in TBT rats. In addition, TBT leads to an increased in the inducible nitric oxide synthase protein expression in the hypothalamus of TBT rats. Morphophysiological abnormalities, including increases in inflammation, a disrupted cellular redox balance, apoptosis, and collagen deposition in the pituitary and adrenal glands, were observed in TBT rats. Increases in adiposity and peroxisome proliferator-activated receptor-γ protein expression in the adrenal gland were observed in TBT rats. Together, these data provide in vivo evidence that TBT leads to functional dissociation between CRH, ACTH, and costicosterone, which could be associated an inflammation and increased of inducible nitric oxide synthase expression in hypothalamus. Thus, TBT exerts toxic effects at different levels on the HPA axis function.

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“…Increased acetylcholinesterase activity and calcium levels in the hypothalamus and pituitary of the Wistar rat [119].…”

Section: Chlorpyrifos Carbaryl Imidaclopridmentioning

confidence: 94%

Neurotoxic Effects of Insecticides Chlorpyrifos, Carbaryl, Imidacloprid, in Different Animal Species

Mora-Gutiérrez¹,

Rubio²,

Romero-López³

et al. 2022

Neurotoxicity - New Advances

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Insecticides are pesticides used to control insects in agriculture, ornamental gardens, homes, and veterinary medicine. Although the toxic effects on the environment and the health of living beings are not fully understood, these pesticides have become the first options for crop protection in agriculture. After herbicides, insecticides are the most extensively used pesticides in agriculture, with large quantities consumed on every continent, primarily in America. Chlorpyrifos, carbaryl, and imidacloprid are among the top ten most used insecticides. Amidst organophosphates, chlorpyrifos has been reported to be used in over fifty food crops. Carbaryl is a carbamate employed as an insecticide, fungicide, herbicide, and nematicide. Similarly, neonicotinoids are the most used insecticide on a global scale. Neonicotinoids include imidacloprid, the second most frequently used pesticide, surpassed only by glyphosate. It is used because it is less toxic to humans. However, insects appear to be less resistant to its compounds. Evidence suggests that these insecticides persist in soils for a long time and have neurotoxic effects in animal species not intended to receive its consequences. Thus, this chapter’s aim is to describe these three pesticides effects and contrast them with the most recent findings regarding their neurotoxic effects in various animal species.

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Recovery byN-acetylcysteine from subchronic exposure to Imidacloprid-induced hypothalamic–pituitary–adrenal (HPA) axis tissues injury in male rats

Cited by 19 publications

References 40 publications

Colibri® insecticide induces male reproductive toxicity: alleviating effects of Lannea acida (Anacardiaceae) in rats

Colibri® insecticide induces male reproductive toxicity: alleviating effects of Lannea acida (Anacardiaceae) in rats

The Environmental Pollutant Tributyltin Chloride Disrupts the Hypothalamic-Pituitary-Adrenal Axis at Different Levels in Female Rats

Neurotoxic Effects of Insecticides Chlorpyrifos, Carbaryl, Imidacloprid, in Different Animal Species

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