Recovery evaluation of rats' damaged tibias: Implantation of core-shell structured bone scaffolds made using hollow braids and a freeze-thawing process

Lin, Jia‐Horng; Lee, Mong-Chuan; Chen, Chih‐Kuang; Huang, Chien‐Lin; Chen, Yueh-Sheng; Wen, Shih-Peng; Kuo, Shu-Ting; Lou, Ching‐Wen

doi:10.1016/j.msec.2017.04.156

Cited by 13 publications

(11 citation statements)

References 40 publications

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“…Axial yarns or 0 • reinforcements are inlay yarns that remain inactive in the production phase and are surrounded by the crimped braided yarns [18,22]. Previous research has used braided structures in combination with porous polymeric materials, proving that those composite structures are in effect stable [23].…”

Section: Introductionmentioning

confidence: 99%

Thermal, Mechanical and Chemical Analysis of Poly(vinyl alcohol) Multifilament and Braided Yarns

et al. 2021

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Poly(vinyl alcohol) (PVA) in multifilament and braided yarns (BY) forms presents great potential for the design of numerous applications. However, such solutions fail to accomplish their requirements if the chemical and thermomechanical behaviour is not sufficiently known. Hence, a comprehensive characterisation of PVA multifilament and three BY architectures (6, 8, and 10 yarns) was performed involving the application of several techniques to evaluate the morphological, chemical, thermal, and mechanical features of those structures. Scanning electron microscopy (SEM) was used to reveal structural and morphological information. Differential thermal analysis (DTA) pointed out the glass transition temperature of PVA at 76 °C and the corresponding crystalline melting point at 210 °C. PVA BY exhibited higher tensile strength under monotonic quasi-static loading in comparison to their multifilament forms. Creep tests demonstrated that 6BY structures present the most deformable behaviour, while 8BY structures are the least deformable. Relaxation tests showed that 8BY architecture presents a more expressive variation of tensile stress, while 10BY offered the least. Dynamic mechanical analysis (DMA) revealed storage and loss moduli curves with similar transition peaks for the tested structures, except for the 10BY. Storage modulus is always four to six times higher than the loss modulus.

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Section: Introductionmentioning

confidence: 99%

Thermal, Mechanical and Chemical Analysis of Poly(vinyl alcohol) Multifilament and Braided Yarns

et al. 2021

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“…In our previous study, we prepared three-layer polyvinyl alcohol (PVA) braid-structure bone scaffolds and confirmed that the porosity and water stability of the braid could be improved by crosslinking the braid with glutaraldehyde [11]. Further, we also fabricated a five-layer core-shell-structure PVA fiber bundles braided bone scaffold on which the hydroxyapatite crystal was directly coated by freeze-drying method and successfully help the recovery of damaged tibias of rats [12]. However, the freeze-drying process requires complex equipment and long process cycle, and the hydroxyapatite crystal is expensive and difficult to commercial application.…”

Section: Introductionmentioning

confidence: 99%

Properties and Mechanism of Hydroxyapatite Coating Prepared by Electrodeposition on a Braid for Biodegradable Bone Scaffolds

Ling

Lin

et al. 2019

Nanomaterials

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Hydroxyapatite (HA) coating is successfully prepared by electrodeposition on the surface of polyvinyl alcohol (PVA)/polylactic acid (PLA) braid which serves as a potential biodegradable bone scaffold. The surface morphology, element composition, crystallinity and chemical bonds of HA coatings at various deposition times (60, 75, 90, 105 and 120 min) are characterized by scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDAX), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR), respectively. Average Surface roughness (Ra) of HA coating is observed by confocal microscopy. The results reveal that the typical characteristic peaks of the FTIR spectrum confirm that HA coating is successfully prepared on the rugged surface of the PVA/PLA braid. The XRD results indicate that the crystallinity of HA can be improved by increasing deposition time. In the 90 min-deposition, hydroxyapatite has a dense and uniform coating morphology, Ca/P ratio of 1.7, roughness of 0.725 μm, which shows the best electrodeposition performance. The formation mechanism of granular and plate-like hydroxyapatite crystals is explained by the structural characteristics of a hydroxyapatite unit cell. This study provides a foundation for a bone scaffold braided by biodegradable fibers.

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“…Im dargestellten Fall war das bei einer kompletten Zerstörung großer Anteile des Ellenbogengelenks nicht möglich. In der Zukunft könnte hier beispielsweise das Einbringen eines künstlichen Gerüsts zur Ausrichtung der Ossifikation zu Verbesserungen führen [16,17].…”

Section: Conclusion MM Bone Lesions Even With Destruction and Dis-unclassified

Multiples Myelom mit Zerstörung des Ellenbogengelenks: Lang anhaltende Symptomkontrolle und Funktionserhalt durch Strahlentherapie

Momm

Moulin

Delic

et al. 2021

Zeitschrift für Palliativmedizin

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Zusammenfassung Hintergrund Eine Strahlentherapie ist die Behandlung der ersten Wahl bei schmerzhaften Knochenläsionen eines Plasmozytoms oder Multiplen Myeloms (MM). Große Knochenläsionen durchbrechen jedoch häufig die Struktur des Knochens und gefährden seine Stabilität. Dann besteht die Indikation zur operativen Stabilisierung. In derartigen Fällen erschweren Risiken und Nebenwirkungen invasiver Maßnahmen Therapieentscheidungen bei oftmals älteren Palliativpatienten oder Patienten in systemischer Tumortherapie. Es ist deshalb wichtig, in solchen Situationen die Ergebnisse nicht-invasiver Therapieoptionen zu untersuchen. Fallbericht Ein 54-jähriger Patient stellte sich mit der etwa 30 cm durchmessenden Läsion eines MMs im distalen Humerus vor, die seinen linken Ellenbogen zerstört hatte und erhebliche Schmerzen verursachte. Der Patient lehnte eine Operation ab, weil er fürchtete, dabei die erhaltene physiologische Funktion seiner linken Hand einzubüßen. Deshalb erhielt er eine alleinige primäre Strahlentherapie mit einer Gesamtdosis von 50 Gy in 20 Fraktionen. Nach der Behandlung war der Patient schmerzfrei, der lokale Tumor war für bislang mehr als fünf Jahre vollständig kontrolliert und die Funktion des linken Armes war zufriedenstellend. Die Strahlentherapie behinderte weitere notwendige systemische Therapien nicht. Schlussfolgerungen Knochenläsionen eines MMs, auch mit einer Zerstörung weiter Teile des Knochens oder von Gelenken, können durch eine primäre Strahlentherapie erfolgreich behandelt werden – mit der Chance auf eine dauerhafte Tumorkontrolle und zufriedenstellende Funktionsergebnisse. Diese Behandlungsoption eröffnet eine vielversprechende Perspektive für ältere Patienten, Patienten in einem reduzierten Allgemeinzustand oder für Patienten mit einem hohen systemischen Therapiedruck, der keine längere Phase der Rekonvaleszenz nach einem chirurgischen Eingriff erlaubt.

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Recovery evaluation of rats' damaged tibias: Implantation of core-shell structured bone scaffolds made using hollow braids and a freeze-thawing process

Cited by 13 publications

References 40 publications

Thermal, Mechanical and Chemical Analysis of Poly(vinyl alcohol) Multifilament and Braided Yarns

Thermal, Mechanical and Chemical Analysis of Poly(vinyl alcohol) Multifilament and Braided Yarns

Properties and Mechanism of Hydroxyapatite Coating Prepared by Electrodeposition on a Braid for Biodegradable Bone Scaffolds

Multiples Myelom mit Zerstörung des Ellenbogengelenks: Lang anhaltende Symptomkontrolle und Funktionserhalt durch Strahlentherapie

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