Recovery of function in aphasia

Fazzini, Enrico; Bachman, David; Albert, Martin L.

doi:10.1016/s0911-6044(86)80003-3

Cited by 10 publications

(3 citation statements)

References 77 publications

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“…Certainly, much of the initial change in the acute aphasic profile results from neurophysiological factors, such as the reduction of edema [Fazzini et al, 1986; Pizzamiglio et al, 2001], resolution of diaschisis [Seitz et al, 1999], reperfusion of ischemic tissue [Fridriksson et al, 2002; Hillis et al, 2006b], and clearing of glutamate [Kwakkel et al, 2004]. However, neural reorganization also plays an important role in the recovery of language functions, especially in the later phases of stroke.…”

Section: Introductionmentioning

confidence: 99%

“…In most cases of aphasia, an individual's language profile will change over time following stroke, and chronic deficits often differ greatly from the acute profile. Certainly, much of the initial change in the acute aphasic profile results from neurophysiological factors, such as the reduction of edema [Fazzini et al, 1986;Pizzamiglio et al, 2001], resolution of diaschisis [Seitz et al, 1999], reperfusion of ischemic tissue [Fridriksson et al, 2002;Hillis et al, 2006b], and clearing of glutamate [Kwakkel et al, 2004].…”

Section: Introductionmentioning

confidence: 99%

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Cortical mapping of naming errors in aphasia

Fridriksson

Baker

Moser

2009

Human Brain Mapping

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Persons with aphasia vary greatly with regard to clinical profile; yet, they all share one common feature—anomia—an impairment in naming common objects. Previous research has demonstrated that particular naming errors are associated with specific left hemisphere lesions. However, we know very little about the cortical activity in the preserved brain areas that is associated with aphasic speech errors. Utilizing functional magnetic resonance imaging (fMRI), we show for the first time that specific speech errors are associated with common cortical activity in different types and severities of aphasia. Specifically, productions of phonemic errors recruited the left posterior perilesional occipital and temporal lobe areas. A similar pattern of activity was associated with semantic errors, albeit in the right hemisphere. This study does not discount variability in cortical activity following left hemisphere stroke; rather, it highlights commonalities in brain modulation in a population of patients with a common diagnosis but vastly different clinical profiles.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cortical mapping of naming errors in aphasia

Fridriksson

Baker

Moser

2009

Human Brain Mapping

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show abstract

“…Previous studies have suggested that when aphasia is due to a left hemisphere stroke, the recovery that occurs appears to involve right hemisphere activity (Geschwind, 1985;Fazzini et al, 1986). For example, it has been observed with EEG studies that patients with bilateral slowing have poor language outcome (Tikofsky, 1960).…”

Section: Discussionmentioning

confidence: 99%