Recovery of Hypoxic Mammalian Cells from Sub-Lethal X-Ray Damage

Elkind, M. M.; Alescio, T.; Swain, Robert W.; Moses, W. B.; Sutton, Harriet

doi:10.1038/2021190a0

Cited by 51 publications

(1 citation statement)

References 10 publications

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“…Cell killing tends to decrease with fraction delivery time increasing because of ongoing sublethal damage repair processes during dose delivery [6,7]. Therefore, it is reasonable to question whether the radiobiological effectiveness of intermittently delivered radiation over a prlonged time has the same biological effectiveness as those delivered continuously through conventional external beam radiation therapy (EBRT).…”

Section: Introductionmentioning

confidence: 99%

The in vivo study on the radiobiologic effect of prolonged delivery time to tumor control in C57BL mice implanted with Lewis lung cancer

Wang

Xiong

et al. 2011

Radiat Oncol

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BackgroundHigh-precision radiation therapy techniques such as IMRT or sterotactic radiosurgery, delivers more complex treatment fields than conventional techniques. The increased complexity causes longer dose delivery times for each fraction. The purpose of this work is to explore the radiobiologic effect of prolonged fraction delivery time on tumor response and survival in vivo.Methods1-cm-diameter Lewis lung cancer tumors growing in the legs of C57BL mice were used. To evaluate effect of dose delivery prolongation, 18 Gy was divided into different subfractions. 48 mice were randomized into 6 groups: the normal control group, the single fraction with 18 Gy group, the two subfractions with 30 min interval group, the seven subfractions with 5 min interval group, the two subfractions with 60 min interval group and the seven subfractions with 10 min interval group. The tumor growth tendency, the tumor growth delay and the mice survival time were analyzed.ResultsThe tumor growth delay of groups with prolonged delivery time was shorter than the group with single fraction of 18 Gy (P < 0.05). The tumor grow delay of groups with prolonged delivery time 30 min was longer than that of groups with prolonged delivery time 60 min P < 0.05). There was no significant difference between groups with same delivery time (P > 0.05). Compared to the group with single fraction of 18 Gy, the groups with prolonged delivery time shorten the mice survival time while there was no significant difference between the groups with prolonged delivery time 30 min and the groups with prolonged delivery time 60 min.ConclusionsThe prolonged delivery time with same radiation dose shorten the tumor growth delay and survival time in the mice implanted with Lewis lung cancer. The anti-tumor effect decreased with elongation of the total interfractional time.

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Section: Introductionmentioning

confidence: 99%

The in vivo study on the radiobiologic effect of prolonged delivery time to tumor control in C57BL mice implanted with Lewis lung cancer

Wang

Xiong

et al. 2011

Radiat Oncol

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Preoperative whole pelvic external irradiation in stage I endometrial cancer

Ritcher

Lucas

Yon

et al. 1981

Cancer

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Between 1966 and 1978, 201 patients with adenocarcinoma of the endometrium were treated at two hospitals in San Diego. Of these patients, 161 had disease limited to the corpus at the time of diagnosis. The majority of these patients received external whole-pelvic irradiation, followed as soon as possible by simple extrafascial hysterectomy and bilateral salpingo-oophorectomy. When this treatment method was used, actuarial survivals of 95% for Stage I disease were achieved. Also reported is the low incidence of wound complications in the group of patients operated soon after cessation of irradiation. The patients treated in this fashion had good survival rates, little morbidity from the adjunctive irradiation, and fewer wound complications than previously anticipated.

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Repair processes in the treatment and induction of cancer with radiation

Elkind

1990

Cancer

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Recovery of Hypoxic Mammalian Cells from Sub-Lethal X-Ray Damage

Cited by 51 publications

References 10 publications

The in vivo study on the radiobiologic effect of prolonged delivery time to tumor control in C57BL mice implanted with Lewis lung cancer

The in vivo study on the radiobiologic effect of prolonged delivery time to tumor control in C57BL mice implanted with Lewis lung cancer

Preoperative whole pelvic external irradiation in stage I endometrial cancer

Repair processes in the treatment and induction of cancer with radiation

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