Recovery of Inflammation, Cardiac, and Muscle Damage Biomarkers After Running a Marathon

Bernat-Adell, María D; Collado-Boira, Eladio; Moles-Julio, Pilar; Panizo-González, Nayara; Martínez-Navarro, Ignacio; Hernando-Fuster, Bárbara; Hernando-Domingo, Carlos

doi:10.1519/jsc.0000000000003167

Cited by 38 publications

(43 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Bernat-Adell et al [23] have discovered that within 24 and 48 h following marathon, athletes' serum CRP levels were significantly higher than those before exercise. Among the other biochemical indicators, we also found that homocysteine tended to be elevated following the exercise.…”

Section: Discussionmentioning

confidence: 99%

Runners' metabolomic changes following marathon

et al. 2020

View full text Add to dashboard Cite

Introduction: Marathon, as a long-distance aerobic exercise, has become a fashionable or popular sport. However, little is known about the holistic metabolic changes occurring within the serum metabolome of athletes after the completion of a marathon. Objectives: The goal of current study was to have an in-depth understanding of the impact of marathon on human metabolomics as well as the relationships among a variety of metabolites. Methods:The 20 studied subjects were all adult males who participated in a marathon. The serum samples of these participants were collected before and after the marathon and the biochemical metabolites in the serum were identified by an untargeted two-dimensional gas chromatography time-of-flight mass spectrometry.Results: All participants completed the marathon within 3 h. Compared to those before exercise, serum urea and creatine kinase, as well as cortisol, elevated significantly (p < 0.05), whereas testosterone decreased significantly (p < 0.01). Metabolomic analysis showed that, compared to those before the competition, metabolites pyruvic acid, glyceric acid, malic acid, cis-aconitic acid, galacturonic acid, methyl fumaric acid, maltotriose, and others increased significantly after the competition (p < 0.05), but glucosamine and O-succinyl-L-homoserine decreased significantly (p < 0.05). Amino acid indexes, such as alanine, L-tyrosine and phenylalanine, increased significantly after exercise compared with those before exercise (p < 0.05), whereas serine, valine and asparagine decreased significantly (p < 0.05). Lipid metabolism indexes, glycerol, glyceric acid, octanoic acid, and quinic acid increased significantly (p < 0.05). Theophylline, xanthine and other indicators of caffeine metabolism increased significantly (p < 0.05). Furthermore, marathon performance, fat percentage, VO 2 max, and hemoglobin were correlated with the serum metabonomic indicators, so were serum testosterone and cortisol.Conclusion: These results illustrate that the metabolism of glucose and lipid of the athletes was enhanced following the marathon match. In addition, the metabolism of glucosamine was decreased and the metabolism of caffeine was increased. Our data provide new insights for marathon performance and nutritional status.

show abstract

Section: Discussionmentioning

confidence: 99%

Runners' metabolomic changes following marathon

et al. 2020

View full text Add to dashboard Cite

show abstract

“…CK peaked at post-race among UT runners and decreased at 24 h post-race, while LT runners showed an increase in CK from post-race to 24 h post-race. Previous studies on half and full road marathons have reported peak values of CK at 24-h post-race [ 31 , 49 ]; while following longer MUM (i.e., 166-km), peak CK has been described to occur immediately post-race [ 4 , 50 ]. In addition, during a flat 200-km race CK was reported to significantly increase from 19-fold pre-race value at mid race to 90-fold pre-race value at the end of the race [ 51 ]; similarly, a continuous rise in CK has been described during a 217-km MUM [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

“…Blood samples were collected from an antecubital vein by venipuncture using BD Vacutainer PST II tubes. Samples were centrifuged at 3500 rpm for ten minutes and kept at 4°C during transport to Vithas Rey Don Jaime Hospital (Castellon), where they were processed using the modular platform Roche / Hitachi clinical chemistry analyzer Cobas c311 (Roche Diagnostics, Penzberg, Germany), as previously published [ 13 , 31 , 32 ]. Biochemical results obtained immediately post-race were adjusted by employing the Dill and Costill method [ 33 ], using hematocrit and hemoglobin to determine the magnitude of plasma volume changes after the race in each participant [ 33 , 34 ].…”

Section: Methodsmentioning

confidence: 99%

Effect of mountain ultramarathon distance competition on biochemical variables, respiratory and lower-limb fatigue

Martínez-Navarro

Sánchez-Gómez²,

Aparicio

et al. 2020

PLoS ONE

Self Cite

View full text Add to dashboard Cite

The study aimed at assessing the acute physiological effects of running a 65-km vs a 107km mountain ultramarathon. Nineteen athletes (15 males and 4 females) from the shorter race and forty three athletes (26 males and 17 females) from the longer race were enrolled. Body weight, respiratory and lower limb strength were assessed before and after the race. Blood samples were obtained before, after and 24-h post-race. Body weight loss did not differ between races. A decrease in squat jump height (p<0.01; d = 1.4), forced vital capacity (p<0.01; d = 0.5), forced expiratory volume in 1 s (p<0.01; d = 0.6), peak inspiratory flow (p<0.01; d = 0.6) and maximal inspiratory pressure (p<0.01; d = 0.8) was observed after the longer race; while, after the shorter race only maximal inspiratory pressure declined (p<0.01; d = 0.5). Greater post-race concentrations of creatine kinase (p<0.01; d = 0.9) and C-reactive protein (p<0.01; d = 2.3) were observed following the longer race, while high-sensitivity cardiac troponin was higher after the shorter race (p<0.01; d = 0.3). Sodium decreased post-competition only after the shorter race (p = 0.02; d = 0.6), while creatinine increased only following the longer race (p<0.01; d = 1.5). In both groups, glomerular filtration rate declined at post-race (longer race: p<0.01, d = 2.1; shorter race: p = 0.01, d = 1.4) and returned to baseline values at 24 h post-race. In summary, expiratory and lower-limb fatigue, and muscle damage and inflammatory response were greater following the longer race; while a higher release of cardiac troponins was observed after the shorter race. The alteration and restoration of renal function was similar after either race.

show abstract

“…Long‐distance endurance running, such as a marathon, can result in a range of signs and symptoms associated with exercise‐induced muscle damage (EIMD). A reduction in functional performance, strength loss, soreness, inflammation, and oxidative stress have all been reported following marathon running 1–6 . Similarly, the deleterious effects of EIMD following a bout of unaccustomed eccentrically biased exercise are well documented 7 .…”

Section: Introductionmentioning

confidence: 97%

“…In contrast, even the most elite, experienced, and well‐trained runners are not spared from the symptoms of EIMD 5 . Following a marathon run, muscle, cardiac, and inflammatory markers have been reported to remain elevated at day eight 1 and the repair of focal muscle fiber damage has been reported to take up to eight weeks 11 . Ultimately, timely recovery from the symptoms associated with EIMD is critical.…”

Section: Introductionmentioning

confidence: 99%

Prolonging the duration of cooling does not enhance recovery following a marathon

Kwiecien

McHugh

Hicks

et al. 2020

Scandinavian Med Sci Sports

View full text Add to dashboard Cite

Runners commonly utilize cryotherapy as part of their recovery strategy. Cryotherapy has been ineffective in mitigating signs and symptoms of muscle damage following marathon running and is limited by its duration of application. Phase change material (PCM) packs can prolong the duration of cooling. This study aimed to test the efficacy of prolonging the duration of cooling using PCM on perceptual recovery, neuromuscular function, and blood markers following a marathon run. Thirty participants completed a marathon run and were randomized to receive three hours of 15°C PCM treatment covering the quadriceps or recover without an intervention (control). Quadriceps soreness, strength, countermovement jump (CMJ) height, creatine kinase (CK), and high sensitivity C‐reactive protein (hsCRP) were recorded at baseline, 24, 48, and 72 hours after the marathon. Following the marathon, strength decreased in both groups (P < .0001), with no difference between groups. Compared to baseline, strength was reduced 24 (P = .004) and 48 hours after the marathon (P = .008) in the control group, but only 24 hours (P = .028) in the PCM group. Soreness increased (P < .0001) and CMJ height decreased (P < .0001) in both groups, with no difference between groups. Compared to baseline, CMJ height was not reduced on any days in the PCM group but was reduced in the control group 24 (P < .0001) and 48 hours (P = .003) after the marathon. CK and hsCRP increased in both groups (P < .0001). Although the marathon run induced significant muscle damage, prolonging the duration of cooling using PCM did not accelerate the resolution of any dependent variables.

show abstract

Recovery of Inflammation, Cardiac, and Muscle Damage Biomarkers After Running a Marathon

Cited by 38 publications

References 43 publications

Runners' metabolomic changes following marathon

Runners' metabolomic changes following marathon

Effect of mountain ultramarathon distance competition on biochemical variables, respiratory and lower-limb fatigue

Prolonging the duration of cooling does not enhance recovery following a marathon

Contact Info

Product

Resources

About