Recovery of polyphenols from red grape pomace and assessment of their antioxidant and anti-cholesterol activities

Ferri, Maura; Bin, Sofia; Vallini, Veronica; Fava, Fabio; Michelini, Elisa; Roda, Aldo; Minnucci, Giordano; Bucchi, Giacomo; Tassoni, Annalisa

doi:10.1016/j.nbt.2015.12.004

Cited by 73 publications

(65 citation statements)

References 22 publications

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“…GAE supplementation improved lipid profile levels in the plasma and liver, which may be associated with reduced body weight and adipose tissue weight. Bioactive compounds such as polyphenols and flavonoids possess antioxidant and cholesterol-lowering activities [ 27 ]. It was reported that seaweed extract containing polyphenols and flavonoids inhibited adipocyte differentiation and lipid accumulation [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Gelidium amansiiextract ameliorates obesity by down-regulating adipogenic transcription factors in diet-induced obese mice

et al. 2017

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BACKGROUND/OBJECTIVESIn this study, we investigated whether Gelidium amansii extract (GAE) ameliorates obesity in diet-induced obese (DIO) mice.MATERIALS/METHODSThe mice were maintained on a high-fat diet (HD) for 5 weeks to generate the DIO mouse model. And then mice fed HD plus 0.5% (GAE1), 1% (GAE2) or 2% (GAE3) for 8 weeks.RESULTSAfter the experimental period, GAE-supplemented groups were significantly lower than the HD group in body weight gain and liver weight. GAE supplemented groups were significantly lower than the HD group in both epididymal and mesenteric adipose tissue mass. The plasma leptin level was significantly higher in the HD group than in GAE-supplemented groups. The leptin level of HD+GAE3 group was significantly lower than that of the HD+conjugated linoleic acid (CLA) group. In contrast, plasma adiponectin level of the HD group was significantly lower than those of HD+GAE2 and HD+GAE3 groups. The expression levels of adipogenic proteins such as fatty acid synthase, sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptor γ, and CCAAT/enhancer binding protein α in the GAE supplemented groups were significantly decreased than those in HD group, respectively. In addition, the expression levels of HD+GAE2 and HD+GAE3 groups are significantly decreased compared to those of HD+CLA group. On the contrary, the expression levels of hormone-sensitive lipase and phospho-AMP-activated protein kinase, proteins associated with lipolysis, were significantly increased in the GAE supplemented groups compared to those in the HD group. HD+GAE3 group showed the highest level among the GAE supplemented groups.CONCLUSIONSThese results suggested that GAE supplementation stimulated the expressions of lipid metabolic factors and reduced weight gain in HD-fed C57BL/6J obese mice.

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Section: Discussionmentioning

confidence: 99%

Gelidium amansiiextract ameliorates obesity by down-regulating adipogenic transcription factors in diet-induced obese mice

et al. 2017

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“…Fluorescence (FL) and bioluminescence (BL) measurements were performed with a Varioskan™ Flash Multimode Reader. The FL signal was obtained exciting samples at 570 nm and acquiring the signal at 610 nm, while the BL signal was acquired with band pass green and red filters after injection of the substrate BrightGlo [ 13 ]. Statistical analysis was performed by using one-way Anova with p < 0.05 accepted as significant.…”

Section: Methodsmentioning

confidence: 99%

Peptide Fractions Obtained from Rice By-Products by Means of an Environment-Friendly Process Show In Vitro Health-Related Bioactivities

et al. 2017

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Recently, the isolation of new health-related bioactive molecules derived from agro-food industrial by-products by means of environment-friendly extraction processes has become of particular interest. In the present study, a protein by-product from the rice starch industry was hydrolysed with five commercial proteolytic enzymes, avoiding the use of solvents or chemicals. The digestion processes were optimised, and the digestates were separated in fractions with four different molecular weight ranges by using a cross-flow membrane filtration technique. Total hydrolysates and fractions were tested in vitro for a wide range of biological activities. For the first time rice-derived peptides were assayed for anti-tyrosinase, anti-inflammatory, cytotoxicity and irritation capacities. Antioxidant and anti-hypertensive activities were also evaluated. Protamex, Alcalase and Neutrase treatments produced peptide fractions with valuable bioactivities without resulting cytotoxic or irritant. Highest levels of bioactivity were detected in Protamex-derived samples, followed by samples treated with Alcalase. Based on the present results, a future direct exploitation of isolated peptide fractions in the nutraceutical, functional food and cosmetic industrial fields may be foreseen.

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“…Moreover, Ferri et al . () highlighted that grape pomace phenols can affect the enzymatic regulation involved in the production of cholesterol (intracellular), thus reducing its level.…”

Section: Applicationsmentioning

confidence: 99%

Valorisation of grape pomace: an approach that is increasingly reaching its maturity – a review

Bordiga

Travaglia

Locatelli

2019

Int J of Food Sci Tech

169

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Traditionally, wine production has been assumed as an environmentally friendly process. However, it requires a considerable amount of resources (e.g. water, fertilisers and organic amendments), and, at the same time, producing a large amount of waste and by-products. Environmental analysis of the wine making process reports that organic solid wastes and wastewater represent the main effluents of the sector. This review aims to make an overview about the recent insights and results related to valorisation of grape pomace and how this approach, considering the number of dedicated studies, is now reaching its maturity. By-products valorisation, a concept increasingly consolidated in the field of industrial residues management, holds immense potential for prospective production. In this regard, the valorisation of grape pomace is proving its effectiveness, obtaining remarkable results.

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Recovery of polyphenols from red grape pomace and assessment of their antioxidant and anti-cholesterol activities

Cited by 73 publications

References 22 publications

Gelidium amansiiextract ameliorates obesity by down-regulating adipogenic transcription factors in diet-induced obese mice

Gelidium amansiiextract ameliorates obesity by down-regulating adipogenic transcription factors in diet-induced obese mice

Peptide Fractions Obtained from Rice By-Products by Means of an Environment-Friendly Process Show In Vitro Health-Related Bioactivities

Valorisation of grape pomace: an approach that is increasingly reaching its maturity – a review

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