Recovery Profiles after Concussion among Male Student-Athletes and Service Cadets with a Family History of Neurodegenerative Disease: Data from the NCAA-DoD CARE Consortium

Harrison, Adam; McAllister, Thomas W.; McCrea, Michael; Broglio, Steven P.; Moore, Robert D.

doi:10.1089/neu.2020.7386

Cited by 1 publication

(2 citation statements)

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“…Diminished neural resilience in both structure and function have been exhibited in those with an fhNDD [71][72][73]. Accordingly, heritable factors associated with neurodegenerative diseases have been linked to impaired neurocognitive recovery following concussion [34,74,75]. Contrary to our hypotheses and prior evidence, fhNDD+ adolescents did not display greater neurocognitive deficits compared to fhNDD− adolescents following a concussion.…”

Section: Discussioncontrasting

confidence: 92%

“…An investigation of composite factors, such as an immediate family history of neurodegenerative disease (fhNDD), would allow researchers to acknowledge the influence of several modifiable risk factors. To date, only one study has investigated the influence of fhNDD on concussion outcomes [34]. However, this study exclusively examined collegeaged males, thus, limiting the generalizability of its findings.…”

Section: Introductionmentioning

confidence: 99%

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The Influence of Family History of Neurodegenerative Disease on Adolescent Concussion Outcomes

Coffman

Harrison

Kay

et al. 2021

JCM

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Evidence suggests that factors associated with a family history of neurodegenerative disease (fhNDD) may influence outcomes following a concussion. However, the relevance of these findings in adolescent populations has not been fully explored. Therefore, the present study sought to evaluate the relationship between fhNDD and neurological outcomes following an adolescent concussion. Data from a local pediatric concussion clinic were used to compare adolescents with (n = 22) and without (n = 44) an fhNDD. Clinical symptom burden, emotional health, cardio-autonomic function, and cognitive performance were assessed at initial (~2 weeks) and follow-up (~5 weeks) post-injury evaluations. Cardio-autonomic function was assessed at rest and during isometric handgrip contraction (IHGC). Results indicated no significant group differences in emotional health or cognitive performance. Across evaluations, those with an fhNDD exhibited greater somatic symptom severity, alterations in HRV at rest, and early blunted cardio-autonomic reactivity during IHGC compared to those without an fhNDD. These findings suggest that positive fhNDD is negatively associated with clinical symptomology and cardio-autonomic functioning following an adolescent concussion. Further, these findings encourage clinicians to utilize a comprehensive neurological evaluation to monitor concussion recovery. Future studies should look into exploring the role of specific neurodegenerative processes and conditions on concussion outcomes in adolescents.

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