Recovery target priorities of people with spinal cord injuries in Korea compared with other countries: a survey

Huh, Sungchul; Ko, Hyun-Yoon

doi:10.1038/s41393-020-0457-z

Cited by 23 publications

(13 citation statements)

References 17 publications

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“…In contrast, magnetic SCS has almost solely addressed bowel and bladder function (83%). While the focus initially of ESCS and TSCS was on lower extremity motor recovery and ambulation, which does not reflect the literature stressing the importance and prioritization of sexual, bladder, and bowel function for individuals living with paraplegia and arm and/or hand function in those living with tetraplegia, [57][58][59] this is currently not the case. Looking at the articles published from January 1, 2020, through March 31, 2021, we find 10 ESCS and 13 TSCS studies examining a diversity of primary outcomes that include bowel and bladder function, spasticity, autonomic dysreflexia, neuropathic pain, cough, cardiovascular function, upper extremity motor recovery, and other motor recovery (ambulation and trunk control).…”

Section: Discussionmentioning

confidence: 99%

Spinal Cord Stimulation Research in the Restoration of Motor, Sensory, and Autonomic Function for Individuals Living With Spinal Cord Injuries: A Scoping Review

Laskin

Waheed

Thorogood

et al. 2022

Archives of Physical Medicine and Rehabilitation

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Section: Discussionmentioning

confidence: 99%

Spinal Cord Stimulation Research in the Restoration of Motor, Sensory, and Autonomic Function for Individuals Living With Spinal Cord Injuries: A Scoping Review

Laskin

Waheed

Thorogood

et al. 2022

Archives of Physical Medicine and Rehabilitation

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“…Although physical disabilities are the major incapacitating alterations, patients are further burdened by the emerging psychological and financial concerns. [3,4] SCI pathophysiology comprehends three main phases: the primary injury starts when a mechanical impact compresses, contuses, or lacerates the spinal cord, disrupting ascending and descending tracts. [5] Massive amounts of inflammatory cells infiltrate injured tissue, leading to the release of pro-inflammatory cytokines initiating the second phase.…”

Section: Introductionmentioning

confidence: 99%

Sustained Release of Human Adipose Tissue Stem Cell Secretome from Star‐Shaped Poly(ethylene glycol) Glycosaminoglycan Hydrogels Promotes Motor Improvements after Complete Transection in Spinal Cord Injury Rat Model

Silva

Schirmer

Pinho

et al. 2023

Adv Healthcare Materials

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Adipose tissue‐derived stem cells (ASCs) have been shown to assist regenerative processes after spinal cord injury (SCI) through their secretome, which promotes several regenerative mechanisms, such as inducing axonal growth, reducing inflammation, promoting cell survival, and vascular remodeling, thus ultimately leading to functional recovery. However, while systemic delivery (e.g., i.v. [intravenous]) may cause off‐target effects in different organs, the local administration has low efficiency due to fast clearance by body fluids. Herein, a delivery system for human ASCs secretome based on a hydrogel formed of star‐shaped poly(ethylene glycol) (starPEG) and the glycosaminoglycan heparin (Hep) that is suitable to continuously release pro‐regenerative signaling mediators such as interleukin (IL)‐4, IL‐6, brain‐derived neurotrophic factor, glial‐cell neurotrophic factor, and beta‐nerve growth factor over 10 days, is reported. The released secretome is shown to induce differentiation of human neural progenitor cells and neurite outgrowth in organotypic spinal cord slices. In a complete transection SCI rat model, the secretome‐loaded hydrogel significantly improves motor function by reducing the percentage of ameboid microglia and systemically elevates levels of anti‐inflammatory cytokines. Delivery of ASC‐derived secretome from starPEG‐Hep hydrogels may therefore offer unprecedented options for regenerative therapy of SCI.

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“…Trunk movement enables ADLs by enlarging the workspace [6] and are even employed when an object or ADL is within arm's length [6,7]. For these reasons, trunk stability has been consistently rated as a high priority for improvement after SCI [8][9][10]. Trunk stability is also an important factor for preventing falls in individuals with SCI [11] and can promote balance and stable function in the wheelchair [12].…”

Section: Introductionmentioning

confidence: 99%

Feedback control of upright seating with functional neuromuscular stimulation during a reaching task after spinal cord injury: a feasibility study

Friederich

Bao

Triolo

et al. 2022

J NeuroEngineering Rehabil

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Background Restoring or improving seated stability after spinal cord injury (SCI) can improve the ability to perform activities of daily living by providing a dynamic, yet stable, base for upper extremity motion. Seated stability can be obtained with activation of the otherwise paralyzed trunk and hip musculature with neural stimulation, which has been shown to extend upper limb reach and improve seated posture. Methods We implemented a proportional, integral, derivative (PID) controller to maintain upright seated posture by simultaneously modulating both forward flexion and lateral bending with functional neuromuscular stimulation. The controller was tested with a functional reaching task meant to require trunk movements and impart internal perturbations through rapid changes in inertia due to acquiring, moving, and replacing objects with one upper extremity. Five subjects with SCI at various injury levels who had received implanted stimulators targeting their trunk and hip muscles participated in the study. Each subject was asked to move a weighted jar radially from a center home station to one of three target stations. The task was performed with the controller active, inactive, or with a constant low level of neural stimulation. Trunk pitch (flexion) and roll (lateral bending) angles were measured with motion capture and plotted against each other to generate elliptical movement profiles for each task and condition. Postural sway was quantified by calculating the ellipse area. Additionally, the mean effective reach (distance between the shoulder and wrist) and the time required to return to an upright posture was determined during reaching movements. Results Postural sway was reduced by the controller in two of the subjects, and mean effective reach was increased in three subjects and decreased for one. Analysis of the major direction of motion showed return to upright movements were quickened by 0.17 to 0.32 s. A 15 to 25% improvement over low/no stimulation was observed for four subjects. Conclusion These results suggest that feedback control of neural stimulation is a viable way to maintain upright seated posture by facilitating trunk movements necessary to complete reaching tasks in individuals with SCI. Replication of these findings on a larger number of subjects would be necessary for generalization to the various segments of the SCI population.

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Recovery target priorities of people with spinal cord injuries in Korea compared with other countries: a survey

Cited by 23 publications

References 17 publications

Spinal Cord Stimulation Research in the Restoration of Motor, Sensory, and Autonomic Function for Individuals Living With Spinal Cord Injuries: A Scoping Review

Spinal Cord Stimulation Research in the Restoration of Motor, Sensory, and Autonomic Function for Individuals Living With Spinal Cord Injuries: A Scoping Review

Sustained Release of Human Adipose Tissue Stem Cell Secretome from Star‐Shaped Poly(ethylene glycol) Glycosaminoglycan Hydrogels Promotes Motor Improvements after Complete Transection in Spinal Cord Injury Rat Model

Feedback control of upright seating with functional neuromuscular stimulation during a reaching task after spinal cord injury: a feasibility study

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