Recreational music-making alters gene expression pathways in patients with coronary heart disease

Bittman, Barry; Croft, Daniel T.; Brinker, Jeannie; Laar, Ryan K. van; Vernalis, Marina; Ellsworth, Darrell L.

doi:10.12659/msm.883807

Cited by 15 publications

(6 citation statements)

References 38 publications

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“…These investigators documented significant changes in NK cell activity and in the level of gene expression for IFN-γ and IL-10. A recent study by Bittman et al [ 57 ] has confirmed the above-mentioned findings on a genetic level: their results support the hypothesis that different sets of genes play important roles in both stress and the relaxation response in humans. If these findings can be confirmed by other research groups, the implications may be of particular importance: they could provide a means for tailored music therapy by identifying the patients who would benefit the most from the clinical effect of music.…”

Section: Music and Medicinesupporting

confidence: 54%

Mozart, Music and Medicine

et al. 2014

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According to the first publication in 1993 by Rauscher et al. [Nature 1993;365:611], the Mozart effect implies the enhancement of reasoning skills solving spatial problems in normal subjects after listening to Mozart's piano sonata K 448. A further evaluation of this effect has raised the question whether there is a link between music-generated emotions and a higher level of cognitive abilities by mere listening. Positron emission tomography and functional magnetic resonance imaging have revealed that listening to pleasurable music activates cortical and subcortical cerebral areas where emotions are processed. These neurobiological effects of music suggest that auditory stimulation evokes emotions linked to heightened arousal and result in temporarily enhanced performance in many cognitive domains. Music therapy applies this arousal in a clinical setting as it may offer benefits to patients by diverting their attention from unpleasant experiences and future interventions. It has been applied in the context of various important clinical conditions such as cardiovascular disorders, cancer pain, epilepsy, depression and dementia. Furthermore, music may modulate the immune response, among other things, evidenced by increasing the activity of natural killer cells, lymphocytes and interferon-γ, which is an interesting feature as many diseases are related to a misbalanced immune system. Many of these clinical studies, however, suffer from methodological inadequacies. Nevertheless, at present, there is moderate but not altogether convincing evidence that listening to known and liked music helps to decrease the burden of a disease and enhances the immune system by modifying stress.

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Section: Music and Medicinesupporting

confidence: 54%

Mozart, Music and Medicine

et al. 2014

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“…In addition, Koyama et al (73) noted that recreational music modulates immunological responses with significant increases of lymphocytes, T cells, CD4 + T cells and memory T cells and higher levels of IFN-γ and IL-6. A more recent study by Bittman et al (74) confirmed the above-mentioned findings on a genetic level: their results support the hypothesis that different sets of genes play important roles in both stress and the relaxation response in humans. All these changes may have a huge impact on skin barrier function and the symptomatology of AD patients.…”

Section: Lifestyle Factors and Leisure Activities In Atopic Dermatitismentioning

confidence: 52%

The impact of lifestyle factors on evolution of atopic dermatitis: An alternative approach (Review)

et al. 2018

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Atopic dermatitis (AD) is a multifactorial chronic inflammatory disease with an incompletely understood etiopathogenesis. With a significant impact on the quality of life of patients, AD has attracted the interest of many research studies aiming to investigate the complex cellular and molecular mechanisms and to identify new therapeutic pathways. Various studies have focused on psycho-immunology, emphasizing the involvement of stress, defined as a general response of the body to external or internal challenges to the AD pathology. Factors like lifestyle and leisure activities may change the behavior of immune cells in AD with a strong impact on the evolution of the disease. Moreover, the poor adherence of AD patient to standard treatment approach has led to the necessity to combine different therapies in the field of complementary and alternative medicine. Although there are still not enough data to conclude that adjuvant therapies are effective in a conventional sense, there are already promising results suggesting that alternative therapeutic strategies could be a main subject of further research.

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“…Music is capable of inducing powerful physiological and psychological emotional states (Bittman et al, 2013;Castillo-Pérez, Gómez-Pérez, Velasco, Pérez-Campos, & Mayoral, 2010).…”

Section: Effects Of Pitch and Timing Expectancy On Musical Emotionmentioning

confidence: 99%

Effects of pitch and timing expectancy on musical emotion.

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Sayed

Dean

et al. 2018

Psychomusicology: Music, Mind, and Brain

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Society. His research interests cover computational, psychological and neuroscientific aspects of music cognition, with a particular focus on dynamic, predictive processing of melodic, rhythmic and harmonic structure, and its impact on emotional and aesthetic experience. He is the author of the IDyOM model of auditory expectation based on statistical learning and probabilistic prediction. EXPECTANCY AND MUSICAL EMOTION3 Abstract Pitch and timing information work hand in hand to create a coherent piece of music; but what happens when this information goes against the norm? Relationships between musical expectancy and emotional responses were investigated in a study conducted with 40 participants: 20 musicians and 20 non-musicians. Participants took part in one of two behavioural paradigms measuring continuous expectancy or emotional responses (arousal and valence) while listening to folk melodies that exhibited either high or low pitch predictability and high or low onset predictability. The causal influence of pitch predictability was investigated in an additional condition where pitch was artificially manipulated and a comparison conducted between original and manipulated forms; the dynamic correlative influence of pitch and timing information and its perception on emotional change during listening was evaluated using cross-sectional time series analysis. The results indicate that pitch and onset predictability are consistent predictors of perceived expectancy and emotional response, with onset carrying more weight than pitch. In addition, musicians and non-musicians do not differ in their responses, possibly due to shared cultural background and knowledge. The results demonstrate in a controlled lab-based setting a precise, quantitative relationship between the predictability of musical structure, expectation and emotional response.

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Recreational music-making alters gene expression pathways in patients with coronary heart disease

Cited by 15 publications

References 38 publications

Mozart, Music and Medicine

Mozart, Music and Medicine

The impact of lifestyle factors on evolution of atopic dermatitis: An alternative approach (Review)

Effects of pitch and timing expectancy on musical emotion.

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