Rectal gastrointestinal stromal tumor with metastasis to the penis: Case report and review of literature

Carlson, Jacob; Alobuia, Wilson; Mizell, Jason S.

doi:10.1016/j.ijscr.2016.11.006

Cited by 4 publications

(5 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The patients included 61 males and 36 females, with a male-to-female ratio of 1.743. However, the sex of one case could not be verified in the text (64).…”

Section: Rare Metastatic Sites and Basic Characteristics Of Patientsmentioning

confidence: 89%

“…When GIST metastasizes to the orbit, a mass may be palpable around the orbit (60) and may manifest as periorbital pain (101), and with involvement of the choroid, vision loss or diplopia may occur (44,48,51,67). Menstrual flow may increase when there is metastasis in the cervix (102), and when the testicles, penis or scrotum are involved, swelling of the testicles and scrotum, difficulty in achieving an erection and obstruction of the urinary tract are typical manifestations (21,38,64,74). When GIST metastasizes to the adrenal gland, the secretion of catecholamine hormones may become abnormal, and symptoms of hypertension may occur (59,103).…”

Section: Diagnosis Of Rare Site Metastasis Of Gistmentioning

confidence: 99%

“…When GIST metastasizes to the male genital system, metastatic GIST in the scrotum appears as a vascular-rich hypoechoic mass on ultrasound (38). In addition, CT may reveal multiple satellite nodules distributed along the spermatic cord (74,77), while contrast-enhanced T1-weighted MRI does not show mass enhancement (64). Lastly, when GIST metastasizes to the spleen, a low-density mass in the spleen is shown using abdominal CT and enhancement is observed on enhanced scans (59).…”

Section: Diagnosis Of Rare Site Metastasis Of Gistmentioning

confidence: 99%

“…Treatment and prognosis details described in the literature for rare metastatic sites of GIST are shown in Table II (18,(20)(21)(22)(23)(24)(25)(26)(27)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)43,44,46,47,(50)(51)(52)(53)(54)(56)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66)(67)(69)(70)(71)(72)74,75,(77)…”

Section: Therapy and Prognosis For Rare Site Gist Metastasesmentioning

confidence: 99%

See 3 more Smart Citations

Clinical characteristics and prognosis of gastrointestinal stromal tumors with rare site metastasis (Review)

Liang

Kong

2022

Oncol Lett

View full text Add to dashboard Cite

Gastrointestinal stromal tumors (GIST) are the most common stromal-derived tumors of the gastrointestinal tract and have a potential metastatic capacity in almost half of all cases, with the most common sites of metastasis being the liver and peritoneum. However, there is evidence that GIST metastasizes to sites other than the liver and peritoneum, which poses challenges for clinical diagnosis and treatment. Therefore, the Cochrane and Medline databases were searched via PubMed in July 2022 using relevant keywords to acquire the literature associated with the metastasis of GIST to rare sites published since from 2000 onwards. Study data comprising age, sex, primary location, metastatic site, mean survival time, clinical signs and symptoms, imaging, pathological features immunohistochemical indices, treatment and prognosis were recorded and analyzed. The 118 metastases at rare sites reported in the literature included bone (n=31), lung (n=10), lymph nodes (n=13), intracranial sites (n=13), skin and subcutaneous tissue (n=10), heart (n=7), skeletal muscle (n=7), orbit and choroid (n=6), pancreas (n=3), spleen (n=2), bone marrow (n=1), testis (n=3), scrotum (n=1), epididymis (n=1), penis (n=1), ovary (n=2), cervix (n=1), kidney (n=1), bladder (n=1), adrenal gland (n=2) and thyroid gland (n=2). From the reviewed studies, it may be concluded that when metastases from gastrointestinal stromal tumors occur at rare sites, the initial symptoms may help in the identification of these sites. In addition, the site-dependent imaging of different metastatic locations may further define the metastases, and the findings of pathological or immunohistochemical analyses may be used to confirm the diagnosis. Contents Introduction 2. Materials and methods3. Rare metastatic sites and basic characteristics of patients 4. Diagnosis of rare site metastasis of GIST 5. Therapy and prognosis for rare site GIST metastases 6.

show abstract

“…The patients included 61 males and 36 females, with a male-to-female ratio of 1.743. However, the sex of one case could not be verified in the text (64).…”

Section: Rare Metastatic Sites and Basic Characteristics Of Patientsmentioning

confidence: 89%

Section: Diagnosis Of Rare Site Metastasis Of Gistmentioning

confidence: 99%

Section: Diagnosis Of Rare Site Metastasis Of Gistmentioning

confidence: 99%

Section: Therapy and Prognosis For Rare Site Gist Metastasesmentioning

confidence: 99%

See 2 more Smart Citations

Clinical characteristics and prognosis of gastrointestinal stromal tumors with rare site metastasis (Review)

Liang

Kong

2022

Oncol Lett

View full text Add to dashboard Cite

show abstract

“…In 57 patients who underwent R0 resection, lymph node metastasis was reported as 8.8%. [ 65 ] The published case reports[ 43 48 50 66 67 68 69 ] and series[ 15 23 25 27 70 71 72 73 74 ] are summarized in Supplementary tables 1 and 2 , respectively, in terms of management modalities used, details of the surgical procedure, radiotherapy treatment doses and fields, and outcomes if available. Taking the literature into consideration, although there is no accepted guideline, elective lymph node irradiation can be omitted in rectal GIST cases.…”

Section: R Adiotherapy I Ndicationsmentioning

confidence: 99%

Radiotherapy for Gastrointestinal Stromal Tumors

Özkan

2018

Chinese Medical Journal

View full text Add to dashboard Cite

Objective:Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors of the gastrointestinal tract, which frequently cause intraabdominal metastases. The current standard of care is surgery for localized cases, and adjuvant imatinib is recommended for tumors with a high risk of recurrence. To date, radiotherapy has not been commonly accepted as a part of multimodality treatment approach other than palliation. However, recently published case reports and some small series suggest that radiotherapy is a valuable option for controlling locally progressive, drug-resistant disease. The aim of this review is to provide a viewpoint from a radiation oncologist concerning the management of GISTs, especially rectal GIST, and clarify the role and technical aspects of radiotherapy in the treatment approach.Data Sources:A comprehensive search in PubMed using the keywords “radiotherapy for rectal GIST” and “rectal GIST” was undertaken. The literature search included the related articles after 1995.Study Selection:The main articles including rectal GIST case reports and GIST series containing rectal cases were the primary references.Results:Surgery is the mainstay of treatment. However, to date, radiotherapy is included in the multidisciplinary treatment strategy of rectal GISTs in some circumstances with palliative, adjuvant, or definitive intent using different treatment doses and fields.Conclusions:Recently reported long-term local control rates indicate that GIST is a radiosensitive disease. This makes radiotherapy a valuable alternative in GIST management with curative intent, especially in patients who (1) cannot tolerate or are resistant to chemotherapy agents, (2) have an unresectable disease, (3) have a gross or microscopic residual disease after surgery, and (4) have a recurrent disease.

show abstract

Involvement of Bmi-1 gene in the development of gastrointestinal stromal tumor by regulating p16 Ink4A /p14 ARF gene expressions: An in vivo and in vitro study

Wang

Cai

et al. 2017

Pathology - Research and Practice

View full text Add to dashboard Cite

Rectal gastrointestinal stromal tumor with metastasis to the penis: Case report and review of literature

Cited by 4 publications

References 20 publications

Clinical characteristics and prognosis of gastrointestinal stromal tumors with rare site metastasis (Review)

Clinical characteristics and prognosis of gastrointestinal stromal tumors with rare site metastasis (Review)

Radiotherapy for Gastrointestinal Stromal Tumors

Involvement of Bmi-1 gene in the development of gastrointestinal stromal tumor by regulating p16 Ink4A /p14 ARF gene expressions: An in vivo and in vitro study

Contact Info

Product

Resources

About