Rectal manifestations of pellagra

Segal, I; Tim, L. Ou; Demetriou, Andreas; Paterson, Alan C.; Hale, Martin; Lerios, M

doi:10.1007/bf01648345

Cited by 20 publications

(14 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The diarrhoea was associated with inflammation of both the large and the small intestine. The most marked changes were seen in the colon and rectum, and the biopsy appearances were similar to those previously described in dietary pellagra [12]. The patient's psychological changes were also compatible with a diagnosis of pellagra, in which the encephalopathy usually takes the form of a psychosis.…”

Section: Discussionsupporting

confidence: 54%

Pellagra with colitis due to a defect in tryptophan metabolism

et al. 1991

View full text Add to dashboard Cite

A 9-year-old girl presented with a red scaly rash confined to sun-exposed areas which started at 2 years of age and had the appearance of pellagra. Investigation of urinary tryptophan metabolites following an oral tryptophan load, showed increased excretion of kynurenine and kynurenic acid but reduced excretion of 3-hydroxy-kynurenine, xanthurenic acid and N1-methyl nicotinamide. These results indicated a defect in the hydroxylation of kynurenine, an important reaction in the synthesis of the nicotinamide nucleotide coenzymes, NAD and NADP, from tryptophan. The patient went on to develop severe colitis and psychological changes. All her symptoms responded to treatment with nicotinamide.

show abstract

Section: Discussionsupporting

confidence: 54%

Pellagra with colitis due to a defect in tryptophan metabolism

et al. 1991

View full text Add to dashboard Cite

show abstract

“…Colitis, which is histologically similar to ulcerative colitis, has also been described in association with pellagra. 5 How the various forms of nutritional colitis relate to ulcerative colitis (UC) is uncertain, but studies have suggested that metabolism of the short chain fatty acid butyrate is impaired in UC.i In these studies, in common with many others, it has not been possible to discover if the change was a primary defect or merely a secondary effect of the disease process.…”

mentioning

confidence: 99%

Ileal and colonic epithelial metabolism in quiescent ulcerative colitis: increased glutamine metabolism in distal colon but no defect in butyrate metabolism.

Finnie

Taylor

Rhodes

1993

Gut

View full text Add to dashboard Cite

Previous studies have shown that butyrate is an important energy source for the distal colon, and that its metabolism may be defective in . ulcerative colitis (UC). A (Gut 1993; 34: 1552-1558 of the colonic epithelium. Colitis, which is histologically similar to ulcerative colitis, has also been described in association with pellagra.5 How the various forms of nutritional colitis relate to ulcerative colitis (UC) is uncertain, but studies have suggested that metabolism of the short chain fatty acid butyrate is impaired in UC.i In these studies, in common with many others, it has not been possible to discover if the change was a primary defect or merely a secondary effect of the disease process.The frequency of 'pouchitis' in ulcerative colitis patients who have colectomy and pouch construction contrasts with the apparent rarity of pouchitis in patients who have the same operation for familial polyposis. '°This implies a potential abnormality of the ileal mucosa in ulcerative colitis that is not evident when the ileum and colon are in normal continuity, with the possible exception of 'backwash ileitis'. In view of this it seems appropriate to study mucosal metabolism in ileal as well as colonic mucosa in UC patients and controls in the expectation that any abnormalities that could be detected in the histologically normal ileum of ulcerative colitis patients would be unlikely to be secondary phenomena.A further problem with the interpretation of some previous studies of mucosal metabolism67 has been concern that the procedure used for isolating a pure epithelial cell population from resected bowel specimens may itself have introduced artefacts, and that these artefactual changes might well have been different in the inflamed colitic tissue from those in the histologically normal colon.This paper describes a technique that allows metabolism of nutrients to be assessed in whole epithelial biopsy specimens, and this technique has been used to assess the metabolism of butyrate and glutamine by ileal and colonic biopsy specimens from patients with idiopathic ulcerative colitis and controls.

show abstract

“…Interestingly, inflammatory diseases of the gut are frequently associated with deficiencies of certain water‐soluble vitamins. For example, 90% of patients with pellagra, who have vitamin B 6 deficiency, suffer from colitis . Biotin regulates activity of natural killer cells, which is reduced, along with systemic biotin levels, in patients with Crohn's disease .…”

Section: Impact On the Innate Immune Systemmentioning

confidence: 99%

Nutrition meets the microbiome: micronutrients and the microbiota

Biesalski

2016

Annals of the New York Academy of Sciences

203

131

View full text Add to dashboard Cite

There is increasing evidence that food is an important factor that influences and shapes the composition and configuration of the gut microbiota. Most studies have focused on macronutrients (fat, carbohydrate, protein) in particular and their effects on the gut microbiota. Although the microbiota can synthesize different water-soluble vitamins, the effects of vitamins synthesized within the microbiota on systemic vitamin status are unclear. Few studies exist on the shuttling of vitamins between the microbiota and intestine and the impact of luminal vitamins on the microbiota. Studying the interactions between vitamins and the microbiota may help to understand the effects of vitamins on the barrier function and immune system of the intestinal tract. Furthermore, understanding the impact of malnutrition, particularly low micronutrient supply, on microbiota development, composition, and metabolism may help in implementing new strategies to overcome the deleterious effects of malnutrition on child development. This article reviews data on the synthesis of different micronutrients and their effects on the human microbiota, and further discusses the consequences of malnutrition on microbiota composition.

show abstract

Rectal manifestations of pellagra

Cited by 20 publications

References 2 publications

Pellagra with colitis due to a defect in tryptophan metabolism

Pellagra with colitis due to a defect in tryptophan metabolism

Ileal and colonic epithelial metabolism in quiescent ulcerative colitis: increased glutamine metabolism in distal colon but no defect in butyrate metabolism.

Nutrition meets the microbiome: micronutrients and the microbiota

Contact Info

Product

Resources

About