Rectosigmoid malakoplakia

Yen, Jia Min; Soh, Nicole; Petersson, Fredrik; Pandya, Garvi J

doi:10.1136/bcr-2017-219464

Cited by 10 publications

(22 citation statements)

References 8 publications

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“…Malakoplakia is a granulomatous disease of infectious origin (1). This rare disease is usually seen in the genitourinary system (1, 2).…”

Section: Introductionmentioning

confidence: 99%

“…Malakoplakia is a granulomatous disease of infectious origin (1). This rare disease is usually seen in the genitourinary system (1, 2). However, different organs such as gastrointestinal tract, skin, lung and central nervous system have also been reported to be affected (1-4).…”

Section: Introductionmentioning

confidence: 99%

“…This rare disease is usually seen in the genitourinary system (1, 2). However, different organs such as gastrointestinal tract, skin, lung and central nervous system have also been reported to be affected (1-4). Malakoplakia generally occurs in immunocompromised patients, though atypical presentation in immunocompetent subjects has also been reported (2, 3).…”

Section: Introductionmentioning

confidence: 99%

“…Malakoplakia generally occurs in immunocompromised patients, though atypical presentation in immunocompetent subjects has also been reported (2, 3). Malakoplakia of the gastrointestinal tract and the other visceral organs has been rarely reported (1, 5). Malakoplakia usually mimics a malignancy but in some instances, it may be accompanied with a malignant tumor (6).…”

Section: Introductionmentioning

confidence: 99%

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Malakoplakia in Association with Adenocarcinoma of Sigmoid Colon; A Case Report

Niknejad¹,

Nili²,

Shirkhoda³

2019

Iran J Pathol

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Malakoplakia is a rare granulomatous disease of the genitourinary system. Gastrointestinal tract is the second most common site of involvement. It usually mimics a malignancy but its association with adenocarcinoma has been rarely reported. A 59-year-old male patient with the history of weight loss and rectal bleeding for two months prior to administration was referred to our hospital. Pre-operative CT scan revealed a large sigmoid colon mass with the extension and invasion to the serosal surface as well as multiple regional metastatic lymph nodes. The patient underwent sigmoidectomy with the primary pathologic diagnosis of adenocarcinoma. Pathologic examination revealed a moderately differentiated adenocarcinoma invading peri-colic adipose tissue and inflammatory reaction compatible with malakoplakia at the invasive borders of the tumor with the extension to the serosal surface.In the patients with gastrointestinal malakoplakia, the presence of possible adjacent malignancy should be screened. The possibility of over-staging should also be considered for adenocarcinoma cases in association with malakoplakia.

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“…Malakoplakia is a granulomatous disease of infectious origin (1). This rare disease is usually seen in the genitourinary system (1, 2).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Malakoplakia in Association with Adenocarcinoma of Sigmoid Colon; A Case Report

Niknejad¹,

Nili²,

Shirkhoda³

2019

Iran J Pathol

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“…There are fewer than 500 cases reported in medical literature with the majority of these presenting in the genitourinary tract. Lesions have also been reported affecting the skin, lungs, bone, thyroid and gastrointestinal systems 5 9–18. Almost all published cases of malakoplakia have been in patients who are immunosuppressed, although cases of malakoplakia in immunocompetent individuals have been reported 19 20…”

Section: Introductionmentioning

confidence: 99%

Cutaneous malakoplakia presenting as a groin swelling and graft failure

Macdonald¹,

Moyes

Clancy

et al. 2019

BMJ Case Rep

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Malakoplakia (from the Greek malakos, ‘soft’ and plakos ‘plaque’) is a granulomatous inflammatory condition, commonly presenting as a plaque in the genitourinary system, but has been shown to affect a wide variety of structures including the skin. Presentation is varied and a high degree of clinical suspicion is needed to make a diagnosis. We report a case of cutaneous malakoplakia presenting as an inguinal swelling in a 48-year-old kidney transplant patient with temporally associated graft dysfunction. New groin swelling in an immunosuppressed patient often prompts investigation centred on a malignant cause. While this is often appropriate, less common infectious and inflammatory causes should be considered. This case highlights the importance of thorough workup and investigation, including histopathology, in immunosuppressed cohorts and acts as a reminder that less common and more complex diagnoses warrant consideration in this group.

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Appendiceal malakoplakia masquerading as a cecal mass

Musonza

Tschen

2020

Journal of Surgical Case Reports

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Appendiceal malakoplakia masquerading as a cecal mass is uniquely rare. The presence of an infiltrate of granular eosinophilic macrophages containing Michaelis–Gutmann bodies on histopathology is pathognomonic of malakoplakia. Cutaneous, gastrointestinal and most commonly urogenital malakoplakia is reported in association with an immunocompromised state, infectious, inflammatory and neoplastic processes. Presentation varies from microscopic disease to plaques, nodules, polypoid lesions and small masses. However, a cecal mass postea proven appendiceal malakoplakia deserves special attention. We could not find similar case reports in the English literature. The pathogenesis of malakoplakia is poorly understood, and it is unclear if it is a harbinger of malignancy, a precursor lesion or an inflammatory marker. In the setting of a dominant appendiceal mass, post-treatment endoscopic and tumor marker surveillance is paramount but, however, undefined in contemporary literature.

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Rectosigmoid malakoplakia

Abstract: We present a rare case of rectosigmoid malakoplakia treated with fluoroquinolone.

Cited by 10 publications

References 8 publications

Malakoplakia in Association with Adenocarcinoma of Sigmoid Colon; A Case Report

Malakoplakia in Association with Adenocarcinoma of Sigmoid Colon; A Case Report

Cutaneous malakoplakia presenting as a groin swelling and graft failure

Appendiceal malakoplakia masquerading as a cecal mass

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