Recurrence and Its Impact on the Health-related Quality of Life in Patients with Gastroesophageal Reflux Disease: A Prospective Follow-up Analysis

Abstract

Background/AimsLimited data exist on the outcome of gastroesophageal reflux disease (GERD) treatment and its impact on the health-related quality of life (HRQoL) in the Asian population. This study aims to evaluate the treatment outcomes, to investigate the factors associated with recurrence, and to evaluate the impact of the treatment outcome on the HRQoL in a Korean GERD population. MethodsThis was a prospective, multicenter study involving a total of 824 GERD patients. The response to treatment was assessed at week 4 (or week 8 for the patients who did not achieve complete resolution [CR] at week 4). The EQ-5D questionnaire was used at baseline, end of treatment, and first recurrence to assess the HRQoL. To assess GERD symptoms, contact of patients by phone at 1, 6, and 12 months following treatment was carried out. ResultsCR was achieved in 65.6% and recurrence was observed in 47.8% following treatment. CR and recurrence rates did not differ by the presence of esophagitis. Multivariate analysis revealed that acid regurgitation (odds ratio 2.249; 95% confidence interval 1.293-3.912; P = 0.004) and both acid regurgitation and heartburn (odds ratio 2.330; 95% confidence interval 1.392-3.901; P = 0.001) were independent risk factors for GERD recurrence. EQ-5D scores were more improved in patients with CR than in those without CR, and worsened more during follow-up in patients with recurrence than in those without recurrence. ConclusionsWe should achieve complete symptom relief and attempt to prevent recurrence in GERD patients to improve their HRQoL.

Quality of life, patient satisfaction, and disease burden in patients with gastroesophageal reflux disease with or without laryngopharyngeal reflux symptoms

“…Gastroesophageal reflux disease is a major clinical problem with a negative impact on quality of life. Higher symptom burden has been associated with significant reductions in HRQL, and patients with persistent symptoms or recurrence are reported to have a worsened HRQL . LPR is an extraesophageal manifestation of GERD causing variable symptoms that may affect daily activity.…”

“…Higher symptom burden has been associated with significant reductions in HRQL, and patients with persistent symptoms or recurrence are reported to have a worsened HRQL. [4][5][6]18,19 LPR is an extraesophageal manifestation of GERD causing variable symptoms that may affect daily activity. To date, however, the impact of LPR symptoms on HRQL in patients with GERD has not been studied.…”

A Double-blind, Randomized, Multicenter Clinical Trial Investigating the Efficacy and Safety of Esomeprazole Single Therapy Versus Mosapride and Esomeprazole Combined Therapy in Patients with Esophageal Reflux Disease

“…1,2 When erosions or ulcers are also observed in the esophagus during endoscopy, it is defined as erosive reflux disease (ERD). GERD impairs the patient's quality of life (QOL) 3 and thus requires appropriate treatment; up to now, medication with protein pump inhibitors (PPIs) has been considered the best therapy. 4,5 The clinical guidelines for GERD published in Korea in 2012, 6 as well as diagnosis and treatment guidelines for GERD published in the United States in 2013, 7 indicate that PPIs are the most effective drugs for the treatment of ERD, with a high level of evidence and a strong level of recommendation.…”

Effect of high‐fat, standard, and functional food meals on esophageal and gastric pH in patients with gastroesophageal reflux disease and healthy subjects

“…When receiving maintenance PPI therapy, 48.7% presented residual symptoms associated with a lower quality of life . Moreover, 47.8% with complete resolution of GERD experienced recurrent symptoms after the withdrawal of PPIs . Moreover, the long‐term use of PPIs may result in food‐borne infections .…”

“…14 Moreover, 47.8% with complete resolution of GERD experienced recurrent symptoms after the withdrawal of PPIs. 15 Moreover, the long-term use of PPIs may result in food-borne infections. 16 A feasible strategy for evaluating the effects of diet on patients with GERD and thus improving the use of dietary modifications, is to explore nonpharmacological treatments such as the intake of functional food to reduce the use of PPIs and to prevent against symptom relapse after the withdrawal of PPIs.…”